Yu-Ning Pan1, Ai-Jing Li2, Xiao-Min Chen3, Jian Wang3, Da-Wei Ren1, Qiu-Li Huang4. 1. Department of Radiology, Ningbo First Hospital, Ningbo Hospital, Zhejiang University, Ningbo, Zhejiang, China; Ningbo University School of Medicine, No. 818 Fenghua Road, Jiangbei District, Ningbo, Zhejiang 315211, China. 2. Department of Radiology, Ningbo No.2 Hospital, Ningbo, Zhejiang, China. 3. Department of Cardiology, Ningbo First Hospital, Ningbo Hospital, Zhejiang University, Ningbo, Zhejiang, China. 4. Department of Radiology, Ningbo First Hospital, Ningbo Hospital, Zhejiang University, Ningbo, Zhejiang, China; Ningbo University School of Medicine, No. 818 Fenghua Road, Jiangbei District, Ningbo, Zhejiang 315211, China. Electronic address: hqlpyn@163.com.
Abstract
RATIONALE AND OBJECTIVES: Using lower tube voltage can reduce the exposure to radiation and the dose of contrast agent. However, lower tube voltage is often linked to more noise and poor image quality, which create a need for more effective technology to resolve this problem. To explore the feasibility of coronary computed tomographic angiography (CCTA) in patients with obesity at low tube voltage (100 kV) and low contrast agent concentration (270 mg/mL) using iterative reconstruction. MATERIALS AND METHODS: A total of 48 patients with body mass indexgreater than 30 kg/m(2) were included and randomly divided into two groups. Group A received a traditional protocol (iopromide 370 mg/mL + 120 kV); group B received a protocol with low tube voltage (100 kV), low contrast agent concentration (270 mg/mL), and iterative reconstruction. The effective dose (ED), average attenuation values, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), the figure of merit (FOM), image quality scores, and the total iodine intake were compared. RESULTS: No significant differences in average CT attenuations, SNR, CNR, and subjective scores were noticed between the two groups (P > 0.05), whereas the FOM of group B was significantly higher than that of group A. Effective radiation dose, total iodine, and iodine injection rate in group B were lower than those of group A (P <0.01). CONCLUSIONS: In patients with obesity, isotonic contrast agent with low iodine concentration and low-dose CCTA were feasible. Substantial reduction in radiation dose and the iodine intake could be achieved without compromising the image quality.
RCT Entities:
RATIONALE AND OBJECTIVES: Using lower tube voltage can reduce the exposure to radiation and the dose of contrast agent. However, lower tube voltage is often linked to more noise and poor image quality, which create a need for more effective technology to resolve this problem. To explore the feasibility of coronary computed tomographic angiography (CCTA) in patients with obesity at low tube voltage (100 kV) and low contrast agent concentration (270 mg/mL) using iterative reconstruction. MATERIALS AND METHODS: A total of 48 patients with body mass index greater than 30 kg/m(2) were included and randomly divided into two groups. Group A received a traditional protocol (iopromide 370 mg/mL + 120 kV); group B received a protocol with low tube voltage (100 kV), low contrast agent concentration (270 mg/mL), and iterative reconstruction. The effective dose (ED), average attenuation values, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), the figure of merit (FOM), image quality scores, and the total iodine intake were compared. RESULTS: No significant differences in average CT attenuations, SNR, CNR, and subjective scores were noticed between the two groups (P > 0.05), whereas the FOM of group B was significantly higher than that of group A. Effective radiation dose, total iodine, and iodine injection rate in group B were lower than those of group A (P <0.01). CONCLUSIONS: In patients with obesity, isotonic contrast agent with low iodine concentration and low-dose CCTA were feasible. Substantial reduction in radiation dose and the iodine intake could be achieved without compromising the image quality.
Authors: Sock Keow Tan; Chai Hong Yeong; Raja Rizal Azman Raja Aman; Kwan Hoong Ng; Yang Faridah Abdul Aziz; Kok Han Chee; Zhonghua Sun Journal: Br J Radiol Date: 2018-03-29 Impact factor: 3.039
Authors: Sock Keow Tan; Kwan Hoong Ng; Chai Hong Yeong; Raja Rizal Azman Raja Aman; Fadhli Mohamed Sani; Yang Faridah Abdul Aziz; Zhonghua Sun Journal: Quant Imaging Med Surg Date: 2019-04
Authors: Hong Seon Lee; Young Joo Suh; Kyunghwa Han; Jin Young Kim; Suyon Chang; Dong Jin Im; Yoo Jin Hong; Hye-Jeong Lee; Jin Hur; Young Jin Kim; Byoung Wook Choi Journal: PLoS One Date: 2018-01-05 Impact factor: 3.240
Authors: José Carlos De La Vega; Pedro Luis Esquinas; Jovan Kaur Gill; Selin Jessa; Bradford Gill; Yogesh Thakur; Katayoun Saatchi; Urs O Häfeli Journal: Contrast Media Mol Imaging Date: 2021-11-01 Impact factor: 3.161