Zhendong Liu1, Yingxin Zhao2, Xidi Wang3, Hua Zhang2, Yi Cui4, Yutao Diao2, Jianchao Xiu2, Xiaolin Sun2, Guosheng Jiang5. 1. Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, 250062, China. Electronic address: zhendongliu876@126.com. 2. Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, 250062, China. 3. Department of Neurology, Zhangqiu People's Hospital, Zhangqiu, Shandong, 250200, China. 4. Department of Radiology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China. 5. Cardio-Cerebrovascular Control and Research Center, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong, 250062, China. Electronic address: jiangguosh@163.com.
Abstract
BACKGROUND & AIMS: Brain white-matter lesions and cognitive impairment are increasing because of the increasing number of patients aged ≥80 y. Wall shear stress (WSS) plays a pivotal role as a fluid mechanical mediator in vascular reactivity and atherosclerosis. In this study, we investigated the associations among common carotid artery (CCA) WSS, white-matter lesions, and cognitive impairment in patients aged ≥80 y METHODS: We enrolled 384 patients aged ≥80 y. All subjects had CCA-WSS, brain white-matter hyperintensities (WMH), and Mini-Mental State Examination (MMSE) assessments and were divided into three groups using tertiles of mean and peak CCA-WSS. RESULTS: For groups classified by the tertile of mean CCA-WSS, WMH, and WMH fraction were decreased; the MMSE score increased from low to high in the respective groups. Differences in WMH, WMH fraction, and the MMSE score were significant between any two groups (all adjusted p < 0.001). Groups classified by the tertile of peak CCA-WSS had the same pattern. Mean and peak CCA-WSS were significantly and inversely correlated with WMH (r = -0.575 and -0.570, respectively; p < 0.001) and WMH fraction (r = -0.574 and -0.569, respectively; p < 0.001) but positively correlated with the MMSE score (r = 0.390 and 0.278, respectively; p < 0.001). Multiple linear backward stepwise regression indicated the mean and peak CCA-WSS were significantly and independently associated with WMH, WMH fraction, and the MMSE score (all adjusted p < 0.001). CONCLUSION: Carotid artery WSS was independently associated with brain white-matter lesions and cognitive impairment in patients aged ≥80 y.
BACKGROUND & AIMS:Brain white-matter lesions and cognitive impairment are increasing because of the increasing number of patients aged ≥80 y. Wall shear stress (WSS) plays a pivotal role as a fluid mechanical mediator in vascular reactivity and atherosclerosis. In this study, we investigated the associations among common carotid artery (CCA) WSS, white-matter lesions, and cognitive impairment in patients aged ≥80 y METHODS: We enrolled 384 patients aged ≥80 y. All subjects had CCA-WSS, brain white-matter hyperintensities (WMH), and Mini-Mental State Examination (MMSE) assessments and were divided into three groups using tertiles of mean and peak CCA-WSS. RESULTS: For groups classified by the tertile of mean CCA-WSS, WMH, and WMH fraction were decreased; the MMSE score increased from low to high in the respective groups. Differences in WMH, WMH fraction, and the MMSE score were significant between any two groups (all adjusted p < 0.001). Groups classified by the tertile of peak CCA-WSS had the same pattern. Mean and peak CCA-WSS were significantly and inversely correlated with WMH (r = -0.575 and -0.570, respectively; p < 0.001) and WMH fraction (r = -0.574 and -0.569, respectively; p < 0.001) but positively correlated with the MMSE score (r = 0.390 and 0.278, respectively; p < 0.001). Multiple linear backward stepwise regression indicated the mean and peak CCA-WSS were significantly and independently associated with WMH, WMH fraction, and the MMSE score (all adjusted p < 0.001). CONCLUSION: Carotid artery WSS was independently associated with brain white-matter lesions and cognitive impairment in patients aged ≥80 y.
Authors: Hannah Gardener; Michelle R Caunca; Chuanhui Dong; Ying Kuen Cheung; Mitchell S V Elkind; Ralph L Sacco; Tatjana Rundek; Clinton B Wright Journal: Stroke Date: 2017-06-19 Impact factor: 7.914
Authors: Evelien S Hoogeveen; Enrico B Arkink; Jeroen van der Grond; Mark A van Buchem; Michel D Ferrari; Gisela M Terwindt; Mark C Kruit Journal: J Cereb Blood Flow Metab Date: 2019-06-18 Impact factor: 6.200