Literature DB >> 26866740

The Impact of Advanced Age on Peri-Operative Outcomes in the Surgical Treatment of Cervical Spondylotic Myelopathy: A Nationwide Study Between 2001 and 2010.

Cyrus M Jalai1, Nancy Worley, Bryan J Marascalchi, Vincent Challier, Shaleen Vira, Sun Yang, Anthony J Boniello, John A Bendo, Virginie Lafage, Peter G Passias.   

Abstract

STUDY
DESIGN: Retrospective multicenter database review.
OBJECTIVE: The aim of this study was to evaluate national postoperative outcomes and hospital characteristics trends from 2001 to 2010 for advanced age CSM patients. SUMMARY OF BACKGROUND DATA: Recent studies show increases in US cervical spine surgeries and CSM diagnoses. However, few have compared national outcomes for elderly and younger CSM patients.
METHODS: A Nationwide Inpatient Sample (NIS) analysis from 2001 to 2010, including CSM patients 25+ who underwent anterior and/or posterior cervical fusion or laminoplasty. Fractures, 9+ levels fused, or any cancers were excluded. Measures included demographics, outcomes, and hospital-related data for 25 to 64 versus 65+ and 65 to 75 versus 76+ age groups. Univariate and logistic regression modeling evaluated procedure-related complications risk in 65+ and 76+ age groups (OR[95% CI]).
RESULTS: Discharges for 35,319 patients in the age range of 25 to 64 years and 19,097 at the age 65+ years were identified. Average comorbidity indices for patients at 65+ years were higher compared to the 25 to 64 years age group (0.79 vs. 0.0.44, P < 0.0001), as was the total complications rate (11.39% vs. 5.93%, P < 0.0001) and charges ($57,449.94 vs. $49,951.11, P < 0.0001). Hospital course for aged 65+ patients was longer (4.76 vs. 3.26 days, P < 0.0001). Mortality risk was higher in the 65+ cohort (3.38[2.93-3.91]), adjusted for covariates. 65+ patients had increased risk of all complications except device-related, for which they had decreased risk (0.61[0.56-0.67]). Patients 76+ years displayed increased hospital charges ($59,197.60 vs. $56,601.44, P < 0.001) and courses (5.77 vs. 4.28 days, P < 0.001) compared to those in the age group 65 to 75 years. These same patients presented with increased Deyo scores (0.83 vs. 0.77, P < 0.001), had increased total complications rate (13.87% vs. 10.20%, P < 0.001), and displayed increased risk for postoperative shock (6.34 [11.16-3.60], P < 0.001), digestive system (1.92 [2.40-1.54], P < 0.001), and wound dehiscence (1.71 [2.56-1.15], P < 0.001).
CONCLUSION: Patients aged 65+ years undergoing CSM surgical management have a higher mortality risk, more procedure-related complications, higher comorbidity burden, longer hospital course, and higher charges. This study provides clinically useful data for surgeons to educate patients and to improve outcomes.

Entities:  

Mesh:

Year:  2016        PMID: 26866740     DOI: 10.1097/BRS.0000000000001181

Source DB:  PubMed          Journal:  Spine (Phila Pa 1976)        ISSN: 0362-2436            Impact factor:   3.468


  7 in total

1.  Functional and survival outcomes in patients undergoing surgical treatment for metastatic disease of the spine.

Authors:  Vignesh K Alamanda; Myra M Robinson; Jeffrey S Kneisl; Joshua C Patt
Journal:  J Spine Surg       Date:  2018-03

2.  Rates of Mortality in Cervical Spine Surgical Procedures and Factors Associated With Its Occurrence Over a 10-Year Period: A Study of 342 477 Patients on the Nationwide Inpatient Sample.

Authors:  Gregory Wyatt Poorman; John Y Moon; Samantha R Horn; Cyrus Jalai; Peter L Zhou; Olivia Bono; Peter G Passias
Journal:  Int J Spine Surg       Date:  2018-08-03

3.  Diagnosis and treatment of hidden lesions in "mild" cervical spondylotic myelopathy patients with apparent symptoms.

Authors:  Yaning Sun; Kunlun Yu; Haonan Wang; Yong Shen; Lingde Kong; Jingtao Zhang
Journal:  Medicine (Baltimore)       Date:  2017-07       Impact factor: 1.889

Review 4.  Surgical Outcome of Laminoplasty for Cervical Spondylotic Myelopathy in an Elderly Population - Potentiality for Effective Early Surgical Intervention: A Meta-analysis.

Authors:  Yasuhiro Takeshima; Ryuta Matsuoka; Ichiro Nakagawa; Fumihiko Nishimura; Hiroyuki Nakase
Journal:  Neurol Med Chir (Tokyo)       Date:  2017-05-19       Impact factor: 1.742

5.  National Trends in Demographics and Outcomes Following Cervical Fusion for Cervical Spondylotic Myelopathy.

Authors:  Caroline E Vonck; Joseph E Tanenbaum; Gabriel A Smith; Edward C Benzel; Thomas E Mroz; Michael P Steinmetz
Journal:  Global Spine J       Date:  2017-09-22

6.  Finite Element Analysis of Spinal Cord Stress in a Single Segment Cervical Spondylotic Myelopathy.

Authors:  Shaofeng Yang; Luqiang Qu; Lijie Yuan; Junjie Niu; Dawei Song; Huilin Yang; Jun Zou
Journal:  Front Surg       Date:  2022-03-14

7.  Degenerative Cervical Myelopathy in Higher-Aged Patients: How Do They Benefit from Surgery?

Authors:  Oliver Gembruch; Ramazan Jabbarli; Ali Rashidi; Mehdi Chihi; Nicolai El Hindy; Axel Wetter; Bernd-Otto Hütter; Ulrich Sure; Philipp Dammann; Neriman Özkan
Journal:  J Clin Med       Date:  2019-12-26       Impact factor: 4.241

  7 in total

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