OBJECTIVE: This study evaluated the effect of moderate weight loss on the incidence of knee osteoarthritis (OA) in middle-aged overweight and obese women, without clinical and radiologic knee OA at baseline. METHODS: A total of 353 women (87%) with followup data available were selected from the Prevention of Knee Osteoarthritis in Overweight Females study, which evaluated the preventive effect of a diet and exercise intervention and of oral glucosamine sulfate on the incidence of knee OA. This was an exploratory proof-of-concept analysis, which compared the incidence of knee OA between women who reached the clinically relevant weight loss target of 5 kg or 5% of body weight after 30 months and those who did not reach this target. RESULTS: The weight loss group showed a significantly lower incidence of knee OA according to the primary outcome measure, which was composed of the American College of Rheumatology criteria (clinical and radiographic), Kellgren/Lawrence grade ≥2, and joint space narrowing ≥1.0 mm (15% versus 20%; odds ratio 0.5, 95% confidence interval 0.3-0.9). Moreover, the weight loss also positively affected several health measures, such as blood glucose level, body fat percentage, and blood pressure. CONCLUSION: A reduction of ≥5 kg or 5% of body weight over a 30-month period reduces the risk for the onset of radiographic knee OA in middle-aged overweight and obese women. Because of the slow progression of the disease, a longer followup period will be necessary before the number of prevented cases of knee OA by moderate weight loss becomes clinically more relevant.
OBJECTIVE: This study evaluated the effect of moderate weight loss on the incidence of knee osteoarthritis (OA) in middle-aged overweight and obesewomen, without clinical and radiologic knee OA at baseline. METHODS: A total of 353 women (87%) with followup data available were selected from the Prevention of Knee Osteoarthritis in Overweight Females study, which evaluated the preventive effect of a diet and exercise intervention and of oral glucosamine sulfate on the incidence of knee OA. This was an exploratory proof-of-concept analysis, which compared the incidence of knee OA between women who reached the clinically relevant weight loss target of 5 kg or 5% of body weight after 30 months and those who did not reach this target. RESULTS: The weight loss group showed a significantly lower incidence of knee OA according to the primary outcome measure, which was composed of the American College of Rheumatology criteria (clinical and radiographic), Kellgren/Lawrence grade ≥2, and joint space narrowing ≥1.0 mm (15% versus 20%; odds ratio 0.5, 95% confidence interval 0.3-0.9). Moreover, the weight loss also positively affected several health measures, such as blood glucose level, body fat percentage, and blood pressure. CONCLUSION: A reduction of ≥5 kg or 5% of body weight over a 30-month period reduces the risk for the onset of radiographic knee OA in middle-aged overweight and obesewomen. Because of the slow progression of the disease, a longer followup period will be necessary before the number of prevented cases of knee OA by moderate weight loss becomes clinically more relevant.
Authors: Gabby B Joseph; Charles E McCulloch; Michael C Nevitt; Jan Neumann; Alexandra S Gersing; Martin Kretzschmar; Benedikt J Schwaiger; John A Lynch; Ursula Heilmeier; Nancy E Lane; Thomas M Link Journal: J Magn Reson Imaging Date: 2017-11-16 Impact factor: 4.813
Authors: Gabby B Joseph; Charles E McCulloch; Michael C Nevitt; Alexandra S Gersing; Benedikt J Schwaiger; Martin Kretzschmar; Ursula Heilmeier; Thomas M Link Journal: J Magn Reson Imaging Date: 2017-02-16 Impact factor: 4.813
Authors: Lianzhi Chen; Jessica Jun Yi Zheng; Guangyi Li; Jun Yuan; Jay R Ebert; Hengyuan Li; John Papadimitriou; Qingwen Wang; David Wood; Christopher W Jones; Minghao Zheng Journal: J Orthop Translat Date: 2020-05-15 Impact factor: 5.191
Authors: Nuria E J Jansen; Dieuwke Schiphof; Edwin Oei; Judith Bosmans; Jolande van Teeffelen; Anita Feleus; Jos Runhaar; Joyce van Meurs; Sita M A Bierma-Zeinstra; Marienke van Middelkoop Journal: BMJ Open Date: 2022-03-04 Impact factor: 2.692
Authors: Kaitlyn M Berry; Tuhina Neogi; Joshua F Baker; Jason M Collins; Jason R Waggoner; Chia-Wen Hsiao; Stephen S Johnston; Michael P LaValley; Andrew C Stokes Journal: Arthritis Care Res (Hoboken) Date: 2021-03 Impact factor: 4.794