Literature DB >> 268654

Authentic beta-globin mRNA sequences in homozygous betaO-thalassemia.

G F Temple, J C Chang, Y W Kan.   

Abstract

In a patient with homozygous betaO-thalassemia in whom studies of reticulocyte hemoglobin synthesis showed no beta-globin chain synthesis in vivo and in vitro, molecular hybridization studies revealed RNA sequences complementary to beta-globin cDNA. The fact that these sequences were authentic beta-globin mRNA was shown by fingerprint analysis of T1 ribonuclease-digested mRNA and by sequencing of oligonucleotides unique to beta-globin mRNA. The beta-mRNA that failed to direct beta-globin chain synthesis was not detectably shortened or degraded and contained poly(A) sequences.

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Year:  1977        PMID： 268654      PMCID： PMC431405          DOI： 10.1073/pnas.74.7.3047

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  Abnormal or absent beta mRNA in betao Ferrara and gene deletion in delta beta thalassaemia.

Authors:  F Ramirez; J V O'Donnell; P A Marks; A Bank; S Musumeci; G Schilirò; G Pizzarelli; G Russo; B Luppis; R Gambino
Journal:  Nature       Date:  1976-10-07       Impact factor: 49.962

2.  A new method for sequencing DNA.

Authors:  A M Maxam; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

3.  Nucleotide sequences of human globin messenger RNA.

Authors:  B G Forget; C A Marotta; S M Weissman; I M Verma; R P McCaffrey; D Baltimore
Journal:  Ann N Y Acad Sci       Date:  1974-11-29       Impact factor: 5.691

4.  In vitro synthesis of DNA complementary to rabbit reticulocyte 10S RNA.

Authors:  I M Verma; G F Temple; H Fan; D Baltimore
Journal:  Nat New Biol       Date:  1972-02-09

5.  Absence of messenger RNA for beta globin chain in beta(0) thalassaemia.

Authors:  B G Forget; E J Benz; A Skoultchi; C Baglioni; D Housman
Journal:  Nature       Date:  1974-02-08       Impact factor: 49.962

Review 6.  Molecular basis of thalassaemia.

Authors:  J B Clegg; D J Weatherall
Journal:  Br Med Bull       Date:  1976-09       Impact factor: 4.291

7.  Studies on the sequence of the 3'-terminal region of turnip-yellow-mosaic-virus RNA.

Authors:  M Silberklang; A Prochiantz; A L Haenni; U L Rajbhandary
Journal:  Eur J Biochem       Date:  1977-02

8.  Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors:  H Aviv; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

9.  Quantitative deficiency of chain-specific globin messenger ribonucleic acids in the thalassemia syndromes.

Authors:  D Housman; B G Forget; A Skoultchi; E J Benz
Journal:  Proc Natl Acad Sci U S A       Date:  1973-06       Impact factor: 11.205

10.  Decreased globin messenger RNA in thalassemia detected by molecular hybridization.

Authors:  D L Kacian; R Gambino; L W Dow; E Grossbard; C Natta; F Ramirez; S Spiegelman; P A Marks; A Bank
Journal:  Proc Natl Acad Sci U S A       Date:  1973-06       Impact factor: 11.205
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  26 in total

1.  cDNA cloning of a 30 kDa erythrocyte membrane protein associated with Rh (Rhesus)-blood-group-antigen expression.

Authors:  N D Avent; K Ridgwell; M J Tanner; D J Anstee
Journal:  Biochem J       Date:  1990-11-01       Impact factor: 3.857

2.  Isolation and characterization of cDNA clones for human erythrocyte beta-spectrin.

Authors:  J T Prchal; B J Morley; S H Yoon; T L Coetzer; J Palek; J G Conboy; Y W Kan
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205

3.  Defects in DNA and globin messenger RNA in homozygotes for hemoglobin Lepore.

Authors:  F Ramirez; J G Mears; U Nudel; A Bank; L Luzzatto; G DiPrisco; R D'Avino; G Pepe; L Camardella; R Gambino; R Cimino; N Quattrin
Journal:  J Clin Invest       Date:  1979-04       Impact factor: 14.808

4.  Multiple protein 4.1 isoforms produced by alternative splicing in human erythroid cells.

Authors:  J G Conboy; J Chan; N Mohandas; Y W Kan
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

5.  The nucleotide sequence of the 5' untranslated region of human gamma-globin mRNA.

Authors:  J C Chang; R Poon; K H Neumann; Y W Kan
Journal:  Nucleic Acids Res       Date:  1978-10       Impact factor: 16.971

6.  Differentiation-associated switches in protein 4.1 expression. Synthesis of multiple structural isoforms during normal human erythropoiesis.

Authors:  J A Chasis; L Coulombel; J Conboy; S McGee; K Andrews; Y W Kan; N Mohandas
Journal:  J Clin Invest       Date:  1993-01       Impact factor: 14.808

7.  Structure and expression of a cloned beta o thalassaemic globin gene.

Authors:  N Moschonas; E de Boer; F G Grosveld; H H Dahl; S Wright; C K Shewmaker; R A Flavell
Journal:  Nucleic Acids Res       Date:  1981-09-11       Impact factor: 16.971

8.  Two cloned beta thalassemia genes are associated with amber mutations at codon 39.

Authors:  R Pergolizzi; R A Spritz; S Spence; M Goossens; Y W Kan; A Bank
Journal:  Nucleic Acids Res       Date:  1981-12-21       Impact factor: 16.971

9.  alpha-Thalassemia caused by an unstable alpha-globin mutant.

Authors:  S A Liebhaber; Y W Kan
Journal:  J Clin Invest       Date:  1983-03       Impact factor: 14.808

10.  Molecular basis for nondeletion alpha-thalassemia in American blacks. Alpha 2(116GAG----UAG).

Authors:  S A Liebhaber; M B Coleman; J G Adams; F E Cash; M H Steinberg
Journal:  J Clin Invest       Date:  1987-07       Impact factor: 14.808
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