| Literature DB >> 26864385 |
Ruoyu Xu1, Youfu Wang1,2, Xiaopin Duan1, Kuangda Lu1, Daniel Micheroni1, Aiguo Hu2, Wenbin Lin1.
Abstract
We report the design of a phosphorescence/fluorescence dual-emissive nanoscale metal-organic framework (NMOF), R-UiO, as an intracellular oxygen (O2) sensor. R-UiO contains a Pt(II)-porphyrin ligand as an O2-sensitive probe and a Rhodamine-B isothiocyanate ligand as an O2-insensitive reference probe. It exhibits good crystallinity, high stability, and excellent ratiometric luminescence response to O2 partial pressure. In vitro experiments confirmed the applicability of R-UiO as an intracellular O2 biosensor. This work is the first report of a NMOF-based intracellular oxygen sensor and should inspire the design of ratiometric NMOF sensors for other important analytes in biological systems.Entities:
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Year: 2016 PMID： 26864385 PMCID： PMC5139906 DOI： 10.1021/jacs.5b13458
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419