Mariangela Rondanelli1, Catherine Klersy2, Gilles Terracol3, Jacopo Talluri4, Roberto Maugeri3, Davide Guido5, Milena A Faliva6, Bruno S Solerte7, Marisa Fioravanti7, Henry Lukaski8, Simone Perna6. 1. Department of Public Health and Experimental and Forensic Medicine, Section of Human Nutrition and Dietetics, Azienda Human Service of Pavia, mariangela.rondanelli@unipv.it. 2. Biometry and Clinical Epidemiology Service, San Matteo Hospital, Pavia, Italy; 3. Research and Clinical Investigation Department, Company Medical Dietetics, Savigliano, Italy; 4. Research and Clinical Investigation Department, Akern, Pontassieve, Italy; and. 5. Medical and Genomic Statistics Unit, Department of Brain and Behavioral Sciences, and. 6. Department of Public Health and Experimental and Forensic Medicine, Section of Human Nutrition and Dietetics, Azienda Human Service of Pavia. 7. Department of Internal Medicine, University of Pavia, Pavia, Italy; 8. Department of Kinesiology and Public Health Education, Hyslop Sports Center, University of North Dakota, Grand Forks, ND.
Abstract
BACKGROUND: Interventions to attenuate the adverse effects of age-related loss of skeletal muscle and function include increased physical activity and nutritional supplementation. OBJECTIVE: This study tested the hypothesis that nutritional supplementation with whey protein (22 g), essential amino acids (10.9 g, including 4 g leucine), and vitamin D [2.5 μg (100 IU)] concurrent with regular, controlled physical activity would increase fat-free mass, strength, physical function, and quality of life, and reduce the risk of malnutrition in sarcopenic elderly persons. DESIGN: A total of 130 sarcopenic elderly people (53 men and 77 women; mean age: 80.3 y) participated in a 12-wk randomized, double-blind, placebo-controlled supplementation trial. All participants concurrently took part in a controlled physical activity program. We examined body composition with dual-energy X-ray absorptiometry, muscle strength with a handgrip dynamometer, and blood biochemical indexes of nutritional and health status, and evaluated global nutritional status, physical function, and quality of life before and after the 12 wk of intervention. RESULTS: Compared with physical activity and placebo, supplementation plus physical activity increased fat-free mass (1.7-kg gain, P < 0.001), relative skeletal muscle mass (P = 0.009), android distribution of fat (P = 0.021), handgrip strength (P = 0.001), standardized summary scores for physical components (P = 0.030), activities of daily living (P = 0.001), mini nutritional assessment (P = 0.003), and insulin-like growth factor I (P = 0.002), and lowered C-reactive protein (P = 0.038). CONCLUSION:Supplementation with whey protein, essential amino acids, and vitamin D, in conjunction with age-appropriate exercise, not only boosts fat-free mass and strength but also enhances other aspects that contribute to well-being in sarcopenic elderly. This trial was registered at clinicaltrials.gov as NCT02402608.
RCT Entities:
BACKGROUND: Interventions to attenuate the adverse effects of age-related loss of skeletal muscle and function include increased physical activity and nutritional supplementation. OBJECTIVE: This study tested the hypothesis that nutritional supplementation with whey protein (22 g), essential amino acids (10.9 g, including 4 g leucine), and vitamin D [2.5 μg (100 IU)] concurrent with regular, controlled physical activity would increase fat-free mass, strength, physical function, and quality of life, and reduce the risk of malnutrition in sarcopenic elderly persons. DESIGN: A total of 130 sarcopenic elderly people (53 men and 77 women; mean age: 80.3 y) participated in a 12-wk randomized, double-blind, placebo-controlled supplementation trial. All participants concurrently took part in a controlled physical activity program. We examined body composition with dual-energy X-ray absorptiometry, muscle strength with a handgrip dynamometer, and blood biochemical indexes of nutritional and health status, and evaluated global nutritional status, physical function, and quality of life before and after the 12 wk of intervention. RESULTS: Compared with physical activity and placebo, supplementation plus physical activity increased fat-free mass (1.7-kg gain, P < 0.001), relative skeletal muscle mass (P = 0.009), android distribution of fat (P = 0.021), handgrip strength (P = 0.001), standardized summary scores for physical components (P = 0.030), activities of daily living (P = 0.001), mini nutritional assessment (P = 0.003), and insulin-like growth factor I (P = 0.002), and lowered C-reactive protein (P = 0.038). CONCLUSION: Supplementation with whey protein, essential amino acids, and vitamin D, in conjunction with age-appropriate exercise, not only boosts fat-free mass and strength but also enhances other aspects that contribute to well-being in sarcopenic elderly. This trial was registered at clinicaltrials.gov as NCT02402608.
Authors: I Ottestad; A T Løvstad; G O Gjevestad; H Hamarsland; J Šaltytė Benth; L F Andersen; A Bye; A S Biong; K Retterstøl; P O Iversen; T Raastad; S M Ulven; K B Holven Journal: J Nutr Health Aging Date: 2017 Impact factor: 4.075
Authors: Julie Shlisky; David E Bloom; Amy R Beaudreault; Katherine L Tucker; Heather H Keller; Yvonne Freund-Levi; Roger A Fielding; Feon W Cheng; Gordon L Jensen; Dayong Wu; Simin N Meydani Journal: Adv Nutr Date: 2017-01-17 Impact factor: 8.701
Authors: M Negro; S Perna; D Spadaccini; L Castelli; L Calanni; M Barbero; C Cescon; M Rondanelli; G D'Antona Journal: J Nutr Health Aging Date: 2019 Impact factor: 4.075