Literature DB >> 26863937

The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.

Julian D Hegemann1, Christopher D Fage, Shaozhou Zhu, Klaus Harms, Francesco Saverio Di Leva, Ettore Novellino, Luciana Marinelli, Mohamed A Marahiel.   

Abstract

Lasso peptides are fascinating natural products with a unique structural fold that can exhibit tremendous thermal stability. Here, we investigate factors responsible for the thermal stability of caulosegnin II. By employing X-ray crystallography, mutational analysis and molecular dynamics simulations, the ring residue proline 8 was proven to be crucial for thermal stability.

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Year:  2016        PMID： 26863937     DOI： 10.1039/c6mb00081a

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  11 in total

1.  Heterologous and in Vitro Reconstitution of Fuscanodin, a Lasso Peptide from Thermobifida fusca.

Authors:  Joseph D Koos; A James Link
Journal:  J Am Chem Soc       Date:  2018-12-27       Impact factor: 15.419

2.  Evidence of Cis/Trans-Isomerization at Pro7/Pro16 in the Lasso Peptide Microcin J25.

Authors:  Kevin Jeanne Dit Fouque; Julian D Hegemann; Séverine Zirah; Sylvie Rebuffat; Ewen Lescop; Francisco Fernandez-Lima
Journal:  J Am Soc Mass Spectrom       Date:  2019-03-04       Impact factor: 3.109

3.  Signatures of Mechanically Interlocked Topology of Lasso Peptides by Ion Mobility-Mass Spectrometry: Lessons from a Collection of Representatives.

Authors:  Kevin Jeanne Dit Fouque; Hélène Lavanant; Séverine Zirah; Julian D Hegemann; Marcel Zimmermann; Mohamed A Marahiel; Sylvie Rebuffat; Carlos Afonso
Journal:  J Am Soc Mass Spectrom       Date:  2016-11-03       Impact factor: 3.109

4.  Heterologous production of a new lasso peptide brevunsin in Sphingomonas subterranea.

Authors:  Shinya Kodani; Hikaru Hemmi; Yuto Miyake; Issara Kaweewan; Hiroyuki Nakagawa
Journal:  J Ind Microbiol Biotechnol       Date:  2018-09-06       Impact factor: 3.346

5.  Thermal Unthreading of the Lasso Peptides Astexin-2 and Astexin-3.

Authors:  Caitlin D Allen; Maria Y Chen; Alexander Y Trick; Dan Thanh Le; Andrew L Ferguson; A James Link
Journal:  ACS Chem Biol       Date:  2016-09-15       Impact factor: 5.100

Review 6.  How to harness biosynthetic gene clusters of lasso peptides.

Authors:  Shinya Kodani; Kohta Unno
Journal:  J Ind Microbiol Biotechnol       Date:  2020-07-23       Impact factor: 3.346

7.  Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications.

Authors:  Julian D Hegemann; Silvia C Bobeica; Mark C Walker; Ian R Bothwell; Wilfred A van der Donk
Journal:  ACS Synth Biol       Date:  2019-05-08       Impact factor: 5.110

8.  Insights into the Unique Phosphorylation of the Lasso Peptide Paeninodin.

Authors:  Shaozhou Zhu; Julian D Hegemann; Christopher D Fage; Marcel Zimmermann; Xiulan Xie; Uwe Linne; Mohamed A Marahiel
Journal:  J Biol Chem       Date:  2016-05-05       Impact factor: 5.157

9.  Streptomyces griseocarneus R132 expresses antimicrobial genes and produces metabolites that modulate Galleria mellonella immune system.

Authors:  Kátia Aparecida de Siqueira; Rhavena Graziela Liotti; Janaina Rosa de Sousa; Suzana Junges Vendruscullo; Gilza Barcelos de Souza; Leonardo Gomes de Vasconcelos; Ana Helena Januário; Tiago Antônio de Oliveira Mendes; Marcos Antônio Soares
Journal:  3 Biotech       Date:  2021-08-04       Impact factor: 2.893

Review 10.  New developments in RiPP discovery, enzymology and engineering.

Authors:  Manuel Montalbán-López; Thomas A Scott; Sangeetha Ramesh; Imran R Rahman; Auke J van Heel; Jakob H Viel; Vahe Bandarian; Elke Dittmann; Olga Genilloud; Yuki Goto; María José Grande Burgos; Colin Hill; Seokhee Kim; Jesko Koehnke; John A Latham; A James Link; Beatriz Martínez; Satish K Nair; Yvain Nicolet; Sylvie Rebuffat; Hans-Georg Sahl; Dipti Sareen; Eric W Schmidt; Lutz Schmitt; Konstantin Severinov; Roderich D Süssmuth; Andrew W Truman; Huan Wang; Jing-Ke Weng; Gilles P van Wezel; Qi Zhang; Jin Zhong; Jörn Piel; Douglas A Mitchell; Oscar P Kuipers; Wilfred A van der Donk
Journal:  Nat Prod Rep       Date:  2020-09-16       Impact factor: 15.111
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