Dilek Arpaci1, Sevim Karakas Celik2, Murat Can3, Esra Ermiş4, Fatih Kuzu1, Furuzan Kokturk5, Ayse Ceylan Hamamcioglu6, Ahmet Dursun4, Taner Bayraktaroglu1. 1. a Faculty of Medicine, Department of Endocrinology and Metabolism , Bulent Ecevit University , Zonguldak , Turkey. 2. b Graduate School of Natural and Applied Sciences, Department of Biology , Bulent Ecevit University , Zonguldak , Turkey. 3. c Faculty of Medicine, Department of Biochemistry , Bulent Ecevit University , Zonguldak , Turkey. 4. d Faculty of Arts and Sciences, Department of Molecular Biology and Genetics , Bulent Ecevit University , Zonguldak , Turkey. 5. e Faculty of Medicine, Department of Biostatistics , Bulent Ecevit University , Zonguldak , Turkey. 6. f Faculty of Chemisty , Bulent Ecevit University , Zonguldak , Turkey.
Abstract
BACKGROUND: Acromegalic patients have increased cardiometabolic risk factors due to an elevation of growth hormone (GH) levels. Human serum paraoxonase (PON), a high-density lipoprotein (HDL)-related enzyme, is one of the major bioscavengers and decreases the oxidation of low-density lipoprotein (LDL), a key regulator in the pathogenesis of atherosclerosis. In this study, we investigated a potential relationship between serum PON levels or PON polymorphisms and acromegaly. METHODS: A total of 48 acromegalic patients and 44 healthy controls were included in this study. Serum GH levels, insulin-like growth factor-1 levels and lipid profiles were measured. Serum PON levels, as well as PON 1 L55M and Q192R gene polymorphisms, were examined. RESULTS: No significant differences were found in terms of age, gender, presence of diabetes, serum LDL cholesterol (LDL-C), HDL-C, or triglyceride levels between the case and control groups (P > 0.05). A statistically significant difference was found in serum PON levels between the cases and controls (P = 0.007). The median serum PON level was 101 ± 63.36 U/l in the case group and 63 ± 60.50 U/l in the control group. There was a significant correlation between serum PON levels and IGF-1 levels (P = 0.004, r = 0.319); however, no significant differences were found in PON1 L55M and PON Q192R polymorphisms between the patients and controls (P = 0.607 and P = 0.308, respectively). In addition, no significant differences were found in serum PON levels in acromegalic patients who were and were not in remission (P = 0.385), nor between those with PON1 L55M and Q192R polymorphisms (P = 0.161 and P = 0.336, respectively). CONCLUSIONS: Elevated serum PON levels were detected in acromegalic patients, independently of their remission status. This suggests protective effects for cardiometabolic risk parameters.
BACKGROUND:Acromegalicpatients have increased cardiometabolic risk factors due to an elevation of growth hormone (GH) levels. Human serum paraoxonase (PON), a high-density lipoprotein (HDL)-related enzyme, is one of the major bioscavengers and decreases the oxidation of low-density lipoprotein (LDL), a key regulator in the pathogenesis of atherosclerosis. In this study, we investigated a potential relationship between serum PON levels or PON polymorphisms and acromegaly. METHODS: A total of 48 acromegalicpatients and 44 healthy controls were included in this study. Serum GH levels, insulin-like growth factor-1 levels and lipid profiles were measured. Serum PON levels, as well as PON 1L55M and Q192R gene polymorphisms, were examined. RESULTS: No significant differences were found in terms of age, gender, presence of diabetes, serum LDL cholesterol (LDL-C), HDL-C, or triglyceride levels between the case and control groups (P > 0.05). A statistically significant difference was found in serum PON levels between the cases and controls (P = 0.007). The median serum PON level was 101 ± 63.36 U/l in the case group and 63 ± 60.50 U/l in the control group. There was a significant correlation between serum PON levels and IGF-1 levels (P = 0.004, r = 0.319); however, no significant differences were found in PON1L55M and PONQ192R polymorphisms between the patients and controls (P = 0.607 and P = 0.308, respectively). In addition, no significant differences were found in serum PON levels in acromegalicpatients who were and were not in remission (P = 0.385), nor between those with PON1L55M and Q192R polymorphisms (P = 0.161 and P = 0.336, respectively). CONCLUSIONS: Elevated serum PON levels were detected in acromegalicpatients, independently of their remission status. This suggests protective effects for cardiometabolic risk parameters.
Authors: Y L Ko; Y S Ko; S M Wang; L A Hsu; C J Chang; P H Chu; N J Cheng; W J Chen; C W Chiang; Y S Lee Journal: Atherosclerosis Date: 1998-12 Impact factor: 5.162