Literature DB >> 26862662

Curing HIV: Moving Forward Faster.

Marcella Flores1, Rowena Johnston1.   

Abstract

There is enormous enthusiasm in the scientific community for finding a cure for HIV. Although much remains to be discovered regarding the mechanisms of viral persistence and how it may be disrupted, some assumptions regarding the goals of a cure, applicability to target populations, and what is required of the assays we employ, may lead to missed opportunities and discoveries and hamper the discovery of a product that will safely cure tens of millions of HIV-infected people around the world. The field will benefit from an awareness and critical interrogation of assumptions that may be implicit in their scientific pursuits.

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Year:  2016        PMID: 26862662      PMCID: PMC4761812          DOI: 10.1089/aid.2016.0004

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN: 0889-2229            Impact factor:   2.205


  37 in total

1.  Persistent low-level viremia in HIV-1 elite controllers and relationship to immunologic parameters.

Authors:  Florencia Pereyra; Sarah Palmer; Toshiyuki Miura; Brian L Block; Ann Wiegand; Alissa C Rothchild; Brett Baker; Rachel Rosenberg; Emily Cutrell; Michael S Seaman; John M Coffin; Bruce D Walker
Journal:  J Infect Dis       Date:  2009-09-15       Impact factor: 5.226

2.  Absence of detectable HIV-1 viremia after treatment cessation in an infant.

Authors:  Deborah Persaud; Hannah Gay; Carrie Ziemniak; Ya Hui Chen; Michael Piatak; Tae-Wook Chun; Matthew Strain; Douglas Richman; Katherine Luzuriaga
Journal:  N Engl J Med       Date:  2013-10-23       Impact factor: 91.245

Review 3.  The end of AIDS: HIV infection as a chronic disease.

Authors:  Steven G Deeks; Sharon R Lewin; Diane V Havlir
Journal:  Lancet       Date:  2013-10-23       Impact factor: 79.321

4.  Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size.

Authors:  Vivek Jain; Wendy Hartogensis; Peter Bacchetti; Peter W Hunt; Hiroyu Hatano; Elizabeth Sinclair; Lorrie Epling; Tzong-Hae Lee; Michael P Busch; Joseph M McCune; Christopher D Pilcher; Frederick M Hecht; Steven G Deeks
Journal:  J Infect Dis       Date:  2013-07-12       Impact factor: 5.226

5.  Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers.

Authors:  Florencia Pereyra; Janet Lo; Virginia A Triant; Jeffrey Wei; Maria J Buzon; Kathleen V Fitch; Janice Hwang; Jennifer H Campbell; Tricia H Burdo; Kenneth C Williams; Suhny Abbara; Steven K Grinspoon
Journal:  AIDS       Date:  2012-11-28       Impact factor: 4.177

6.  Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.

Authors:  Pablo Tebas; David Stein; Winson W Tang; Ian Frank; Shelley Q Wang; Gary Lee; S Kaye Spratt; Richard T Surosky; Martin A Giedlin; Geoff Nichol; Michael C Holmes; Philip D Gregory; Dale G Ando; Michael Kalos; Ronald G Collman; Gwendolyn Binder-Scholl; Gabriela Plesa; Wei-Ting Hwang; Bruce L Levine; Carl H June
Journal:  N Engl J Med       Date:  2014-03-06       Impact factor: 91.245

7.  Evidence for innate immune system activation in HIV type 1-infected elite controllers.

Authors:  Sonya Krishnan; Eleanor M P Wilson; Virginia Sheikh; Adam Rupert; Daniel Mendoza; Jun Yang; Richard Lempicki; Stephen A Migueles; Irini Sereti
Journal:  J Infect Dis       Date:  2013-11-01       Impact factor: 5.226

8.  A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals.

Authors:  Francesco Andrea Procopio; Rémi Fromentin; Deanna A Kulpa; Jessica H Brehm; Anne-Gaelle Bebin; Matthew C Strain; Douglas D Richman; Una O'Doherty; Sarah Palmer; Frederick M Hecht; Rebecca Hoh; Richard J O Barnard; Michael D Miller; Daria J Hazuda; Steven G Deeks; Rafick-Pierre Sékaly; Nicolas Chomont
Journal:  EBioMedicine       Date:  2015-06-27       Impact factor: 8.143

9.  Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure.

Authors:  Ya-Chi Ho; Liang Shan; Nina N Hosmane; Jeffrey Wang; Sarah B Laskey; Daniel I S Rosenbloom; Jun Lai; Joel N Blankson; Janet D Siliciano; Robert F Siliciano
Journal:  Cell       Date:  2013-10-24       Impact factor: 41.582

10.  Immunological biomarkers predict HIV-1 viral rebound after treatment interruption.

Authors:  Jacob Hurst; Matthias Hoffmann; Matthew Pace; James P Williams; John Thornhill; Elizabeth Hamlyn; Jodi Meyerowitz; Chris Willberg; Kersten K Koelsch; Nicola Robinson; Helen Brown; Martin Fisher; Sabine Kinloch; David A Cooper; Mauro Schechter; Giuseppe Tambussi; Sarah Fidler; Abdel Babiker; Jonathan Weber; Anthony D Kelleher; Rodney E Phillips; John Frater
Journal:  Nat Commun       Date:  2015-10-09       Impact factor: 14.919

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  3 in total

1.  Identification of Combinations of Protein Kinase C Activators and Histone Deacetylase Inhibitors That Potently Reactivate Latent HIV.

Authors:  Francesca Curreli; Shahad Ahmed; Sofia M Benedict Victor; Asim K Debnath
Journal:  Viruses       Date:  2020-06-03       Impact factor: 5.048

2.  An ultrasensitive planar array p24 Gag ELISA to detect HIV-1 in diverse biological matrixes.

Authors:  Callie Levinger; J Natalie Howard; Jie Cheng; Pingtao Tang; Amit Joshi; Marta Catalfamo; Alberto Bosque
Journal:  Sci Rep       Date:  2021-12-08       Impact factor: 4.379

3.  The HIV Latency Reversal Agent HODHBt Enhances NK Cell Effector and Memory-Like Functions by Increasing Interleukin-15-Mediated STAT Activation.

Authors:  Amanda B Macedo; Callie Levinger; Bryan N Nguyen; Jonathan Richard; Mamta Gupta; Conrad Russell Y Cruz; Andrés Finzi; Katherine B Chiappinelli; Keith A Crandall; Alberto Bosque
Journal:  J Virol       Date:  2022-07-14       Impact factor: 6.549

  3 in total

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