Literature DB >> 23032411

Increased coronary atherosclerosis and immune activation in HIV-1 elite controllers.

Florencia Pereyra1, Janet Lo, Virginia A Triant, Jeffrey Wei, Maria J Buzon, Kathleen V Fitch, Janice Hwang, Jennifer H Campbell, Tricia H Burdo, Kenneth C Williams, Suhny Abbara, Steven K Grinspoon.   

Abstract

HIV-1 elite controllers spontaneously maintain suppressed levels of viremia, but exhibit significant immune activation. We investigated coronary atherosclerosis by coronary computed tomography angiography (CTA) in elite controllers, nonelite controller, chronically HIV-1 infected, antiretroviral therapy (ART)-treated patients with undetectable viral load ('chronic HIV'), and HIV-negative controls. Prevalence of atherosclerosis (78 vs. 42%, P < 0.05) and markers of immune activation were increased in elite controllers compared with HIV-negative controls. sCD163, a monocyte activation marker, was increased in elite controllers compared with chronic HIV-1 (P < 0.05) and compared with HIV-negative controls (P < 0.05). These data suggest a significant degree of coronary atherosclerosis and monocyte activation among elite controllers.

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Year:  2012        PMID： 23032411      PMCID： PMC3660105          DOI： 10.1097/QAD.0b013e32835a9950

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  22 in total

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Journal:  Immunity       Date:  2008-12-08       Impact factor: 31.745
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  111 in total

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