Kristiina Tertti1, Jorma Toppari2, Helena E Virtanen2, Sergey Sadov2, Tapani Rönnemaa3. 1. Department of Obstetrics and Gynecology, University of Turku and Turku University Hospital, Turku, Finland. 2. Departments of Physiology and Pediatrics, University of Turku, Turku, Finland. 3. Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Abstract
OBJECTIVES: Studies in rodents suggest that metformin treatment during pregnancy may have harmful effects on testicular development in offspring. Our aim was to determine whether metformin treatment of gestational diabetes mellitus (GDM) affects testicular size in male offspring. METHODS: We compared the testicular size in prepubertal boys born to mothers who participated in a randomized controlled trial (RCT) comparing metformin with insulin in the treatment of GDM. Twenty-five (42.4% of invited) and 27 (52.9% of invited) boys whose mothers had been treated withmetformin or insulin, respectively, participated in the study. Testicular size was measured by a ruler, an orchidometer, and by ultrasonography at the age of 33 to 85 months. RESULTS: The mean age of the boys was 60 months at the time of examination, and did not differ between the metformin and insulin group (p = 0.88). There was no difference in testicular size between the boys in the two groups (p always ≥ 0.40), and there were no significant differences in height, weight, BMI, BMI z-score, or waist-to-hip ratio (WHR) between the boys in the groups. CONCLUSIONS:Prepubertal testicular size did not differ between offspring born to metformin-treated mothers and those born to insulin-treated mothers.
RCT Entities:
OBJECTIVES: Studies in rodents suggest that metformin treatment during pregnancy may have harmful effects on testicular development in offspring. Our aim was to determine whether metformin treatment of gestational diabetes mellitus (GDM) affects testicular size in male offspring. METHODS: We compared the testicular size in prepubertal boys born to mothers who participated in a randomized controlled trial (RCT) comparing metformin with insulin in the treatment of GDM. Twenty-five (42.4% of invited) and 27 (52.9% of invited) boys whose mothers had been treated with metformin or insulin, respectively, participated in the study. Testicular size was measured by a ruler, an orchidometer, and by ultrasonography at the age of 33 to 85 months. RESULTS: The mean age of the boys was 60 months at the time of examination, and did not differ between the metformin and insulin group (p = 0.88). There was no difference in testicular size between the boys in the two groups (p always ≥ 0.40), and there were no significant differences in height, weight, BMI, BMI z-score, or waist-to-hip ratio (WHR) between the boys in the groups. CONCLUSIONS: Prepubertal testicular size did not differ between offspring born to metformin-treated mothers and those born to insulin-treated mothers.
Authors: P Tartarin; D Moison; E Guibert; J Dupont; R Habert; V Rouiller-Fabre; N Frydman; S Pozzi; R Frydman; C Lecureuil; P Froment Journal: Hum Reprod Date: 2012-07-18 Impact factor: 6.918
Authors: C Wohlfahrt-Veje; J Tinggaard; K Winther; A Mouritsen; C P Hagen; M G Mieritz; K T de Renzy-Martin; M Boas; J H Petersen; K M Main Journal: Eur J Clin Nutr Date: 2014-01-29 Impact factor: 4.016
Authors: K A Boisen; M Kaleva; K M Main; H E Virtanen; A-M Haavisto; I M Schmidt; M Chellakooty; I N Damgaard; C Mau; M Reunanen; N E Skakkebaek; J Toppari Journal: Lancet Date: 2004-04-17 Impact factor: 79.321
Authors: Tina Kold Jensen; Niels Jørgensen; Margus Punab; Trine B Haugen; Jyrki Suominen; Birute Zilaitiene; Antero Horte; Anne-Grethe Andersen; Elisabeth Carlsen; Øystein Magnus; Valentinas Matulevicius; Ingrid Nermoen; Matti Vierula; Niels Keiding; Jorma Toppari; Niels E Skakkebaek Journal: Am J Epidemiol Date: 2004-01-01 Impact factor: 4.897
Authors: Henriikka Salomäki; Laura H Vähätalo; Kirsti Laurila; Norma T Jäppinen; Anna-Maija Penttinen; Liisa Ailanen; Juan Ilyasizadeh; Ullamari Pesonen; Markku Koulu Journal: PLoS One Date: 2013-02-15 Impact factor: 3.240
Authors: Jessica Santana de Oliveira; Alluanan Adelson do Nascimento Silva; Fernanda Carolina Ribeiro Dias; Elizabeth Lopes de Oliveira; Emanuel Felipe de Oliveira Filho; Pierre Castro Soares; Catarina Michelle de Oliveira Ferreira; Valdemiro Amaro da Silva Junior Journal: Int J Exp Pathol Date: 2022-06-23 Impact factor: 2.793
Authors: Wenneke van Weelden; Vincent Wekker; Leon de Wit; Jacqueline Limpens; Hilkka Ijäs; Aleid G van Wassenaer-Leemhuis; Tessa J Roseboom; Bas B van Rijn; J Hans DeVries; Rebecca C Painter Journal: Diabetes Ther Date: 2018-08-30 Impact factor: 2.945