Literature DB >> 26857496

IL-12Rβ2 has a protective role in relapsing-remitting experimental autoimmune encephalomyelitis.

Chong Xie1, Bogoljub Ciric2, Shuo Yu2, Guang-Xian Zhang2, Abdolmohamad Rostami3.   

Abstract

IL-12Rβ2 is a common receptor subunit of heterodimeric receptors for IL-12 and IL-35, two cytokines that are implicated in immunopathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. We evaluated the role of IL-12Rβ2 in relapsing-remitting EAE (RR-EAE). IL-12Rβ2-deficient SJL/J mice developed markedly more severe clinical EAE, and had greater mortality and more severe relapses compared with wild-type controls. IL-12Rβ2-deficient EAE mice also had more infiltrating mononuclear cells in the CNS, as well as higher T cell proliferative capacity and decreased IFN-γ production at the periphery. These findings demonstrate a protective role of IL-12Rβ2 in RR-EAE.
Copyright © 2015. Published by Elsevier B.V.

Entities:  

Keywords:  Experimental autoimmune encephalomyelitis (EAE); IL-12; IL-12Rβ2; IL-35; Relapse

Mesh：

Substances：

Year:  2015        PMID： 26857496      PMCID： PMC4849275          DOI： 10.1016/j.jneuroim.2015.12.009

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  55 in total

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Authors:  Jin-Qing Liu; Zhenzhen Liu; Xuejun Zhang; Yun Shi; Fatemeh Talebian; Joseph W Carl; Chuan Yu; Fu-Dong Shi; Caroline C Whitacre; Joanne Trgovcich; Xue-Feng Bai
Journal:  J Immunol       Date:  2012-03-02       Impact factor: 5.422

4.  Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor).

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Journal:  J Immunol       Date:  1991-08-01       Impact factor: 5.422

5.  IL-35-mediated induction of a potent regulatory T cell population.

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Journal:  Nat Immunol       Date:  2010-10-17       Impact factor: 25.606

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Journal:  Ann Rheum Dis       Date:  2008-01-16       Impact factor: 19.103

9.  TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

Authors:  Marc Veldhoen; Richard J Hocking; Christopher J Atkins; Richard M Locksley; Brigitta Stockinger
Journal:  Immunity       Date:  2006-02       Impact factor: 31.745

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Journal:  J Neuroimmunol       Date:  1998-10-01       Impact factor: 3.478
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  4 in total

1.  Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice.

Authors:  Giacomo Casella; Javad Rasouli; Alexandra Boehm; Weifeng Zhang; Dan Xiao; Larissa Lumi Watanabe Ishikawa; Rodolfo Thome; Xing Li; Daniel Hwang; Patrizia Porazzi; Sudheer Molugu; Hsin-Yao Tang; Guang-Xian Zhang; Bogoljub Ciric; Abdolmohamad Rostami
Journal:  Sci Transl Med       Date:  2020-11-04       Impact factor: 17.956

2.  Pien Tze Huang Alleviates Relapsing-Remitting Experimental Autoimmune Encephalomyelitis Mice by Regulating Th1 and Th17 Cells.

Authors:  Xuemei Qiu; Qingqing Guo; Xue Liu; Hui Luo; Danping Fan; Yongqi Deng; Hua Cui; Cheng Lu; Ge Zhang; Xiaojuan He; Aiping Lu
Journal:  Front Pharmacol       Date:  2018-10-31       Impact factor: 5.810

3.  A bibliometric analysis of IL-35 research from 2009 to 2018.

Authors:  Xulong Cai; Chenrong Zhou; Li Zhou; Qiaolan Xu
Journal:  PeerJ       Date:  2019-10-30       Impact factor: 2.984

4.  IL-35 promotes CD4+Foxp3+ Tregs and inhibits atherosclerosis via maintaining CCR5-amplified Treg-suppressive mechanisms.

Authors:  Ying Shao; William Y Yang; Fatma Saaoud; Charles Drummer; Yu Sun; Keman Xu; Yifan Lu; Huimin Shan; Ethan M Shevach; Xiaohua Jiang; Hong Wang; Xiaofeng Yang
Journal:  JCI Insight       Date:  2021-10-08
  4 in total

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