Inanc Guvenc1, Sinan Akay2, Selami Ince1, Ramazan Yildiz3, Zafer Kilbas3, Fahrettin G Oysul4, Mustafa Tasar1. 1. 1 Department of Radiology, Gulhane Military Medical School, Ankara, Turkey. 2. 2 Department of Radiology, Sirnak Military Hospital, Sirnak, Turkey. 3. 3 Department of General Surgery, Gulhane Military Medical School, Ankara, Turkey. 4. 4 Department of Public Health, Gulhane Military Medical School, Ankara, Turkey.
Abstract
OBJECTIVE: To investigate the correlation between apparent diffusion coefficient (ADC) values and prognostic factors in patients with invasive ductal carcinoma (IDC). METHODS: 48 lesions belonging to 47 patients with histopathologically proven IDC were examined using conventional MR and diffusion-weighted imaging at a 3.0-T system. All of the patients had modified radical mastectomies or breast-sparing surgery plus axillary lymph node dissection. The ADC values acquired from the ADC maps consisted of six different b-values (0, 50, 100, 500, 1000 and 1500 s mm(-2)) and were compared with the patients' ages, tumour size, histological grade of the lesions, tumour localization, lesions' distance to skin surface and nipples, the existence of axillary lymph node involvement, the number of involved axillary lymph nodes, oestrogen/progesterone receptor status, peritumoral lymphovascular invasion status and the existence of human epidermal growth factor 2 (c-erbB-2) overexpression. RESULTS: A statistically significant relationship was found regarding axillary lymph node involvement (p = 0.027), and oestrogen/progesterone receptor status (p = 0.013). No significant relationship was detected regarding other prognostic factors (p > 0.05). CONCLUSION: Among various prognostic factors, ADC values were significantly correlated with only axillary lymph node positivity and oestrogen/progesterone receptor status. ADVANCES IN KNOWLEDGE: In the present study, the relationship between ADC values of IDC lesions that are acquired at a high magnetic field (3.0 T) system by using multiple b-values and some specific prognostic factors that were not evaluated before in the medical literature was investigated.
OBJECTIVE: To investigate the correlation between apparent diffusion coefficient (ADC) values and prognostic factors in patients with invasive ductal carcinoma (IDC). METHODS: 48 lesions belonging to 47 patients with histopathologically proven IDC were examined using conventional MR and diffusion-weighted imaging at a 3.0-T system. All of the patients had modified radical mastectomies or breast-sparing surgery plus axillary lymph node dissection. The ADC values acquired from the ADC maps consisted of six different b-values (0, 50, 100, 500, 1000 and 1500 s mm(-2)) and were compared with the patients' ages, tumour size, histological grade of the lesions, tumour localization, lesions' distance to skin surface and nipples, the existence of axillary lymph node involvement, the number of involved axillary lymph nodes, oestrogen/progesterone receptor status, peritumoral lymphovascular invasion status and the existence of human epidermal growth factor 2 (c-erbB-2) overexpression. RESULTS: A statistically significant relationship was found regarding axillary lymph node involvement (p = 0.027), and oestrogen/progesterone receptor status (p = 0.013). No significant relationship was detected regarding other prognostic factors (p > 0.05). CONCLUSION: Among various prognostic factors, ADC values were significantly correlated with only axillary lymph node positivity and oestrogen/progesterone receptor status. ADVANCES IN KNOWLEDGE: In the present study, the relationship between ADC values of IDC lesions that are acquired at a high magnetic field (3.0 T) system by using multiple b-values and some specific prognostic factors that were not evaluated before in the medical literature was investigated.
Authors: Jin Chung; Ji Hyun Youk; Jeong-Ah Kim; Hye Mi Gweon; Eun-Kyung Kim; Young Hoon Ryu; Eun Ju Son Journal: Acta Radiol Date: 2013-11-14 Impact factor: 1.990
Authors: Joao V Horvat; Blanca Bernard-Davila; Thomas H Helbich; Michelle Zhang; Elizabeth A Morris; Sunitha B Thakur; R Elena Ochoa-Albiztegui; Doris Leithner; Maria A Marino; Pascal A Baltzer; Paola Clauser; Panagiotis Kapetas; Zsuzsanna Bago-Horvath; Katja Pinker Journal: J Magn Reson Imaging Date: 2019-02-27 Impact factor: 4.813
Authors: Joao V Horvat; Aditi Iyer; Elizabeth A Morris; Aditya Apte; Blanca Bernard-Davila; Danny F Martinez; Doris Leithner; Olivia M Sutton; R Elena Ochoa-Albiztegui; Dilip Giri; Katja Pinker; Sunitha B Thakur Journal: Contrast Media Mol Imaging Date: 2019-11-22 Impact factor: 3.161