A Tejera-Vaquerizo1, M A Descalzo-Gallego2, M M Otero-Rivas3, C Posada-García4, L Rodríguez-Pazos4, I Pastushenko5, R Marcos-Gragera6, I García-Doval7. 1. Servicio de Dermatología, Instituto Dermatológico GlobalDerm, Palma del Río, Córdoba, España. Electronic address: antoniotejera@aedv.es. 2. Unidad de Investigación, Fundación AEDV, Madrid, España. 3. Servicio de Dermatología, Hospital Universitario Lucus Augusti, Lugo, España. 4. Servicio de Dermatología, Complexo Hospitalario Universitario de Vigo, Vigo, España. 5. Interdisciplinary Research Institute, Université Libre de Bruxelles, Bruselas, Bélgica. 6. Institut Català d'Oncologia, Pla Director d'Oncologia, Unitat d'Epidemiologia i Registre de Càncer de Girona (UERCG), Institut d'Investigació Biomèdica de Girona (IdIBGi), Universitat de Girona, Girona, España. 7. Unidad de Investigación, Fundación AEDV, Madrid, España; Servicio de Dermatología, Complexo Hospitalario Universitario de Vigo, Vigo, España.
Abstract
INTRODUCTION AND OBJECTIVES: The aim of this systematic review was to describe the incidence and mortality of basal cell carcinoma, squamous cell carcinoma, melanoma, and Merkel cell carcinoma in Spain. MATERIAL AND METHODS: We performed a search of the MEDLINE and Embase databases and reviewed articles from the Spanish Network of Cancer Registries (REDECAN) and the International Agency for Research on Cancer (IARC). The methodological quality of the studies was evaluated and statistical heterogeneity was measured using the I(2) index. A random-effects model was used to perform the meta-analysis because of the heterogeneity of the data. RESULTS: Thirty-two papers were included in the systematic review. The crude incidence rate for basal cell carcinoma was 113.05 (95% CI, 89.03-137.08) cases per 100 000 person-years for the studies based on the registration methodology normally used by registries (in which only 1 tumor with histological confirmation is counted per person). However, the same incidence rate calculated on the basis of clinical and histologic criteria and counting tumors rather than individual patients was 253.23 (95% CI, 273.01-269.45) cases per 100 000 person-years. The incidence was 38.16 (95% CI, 31.72-39.97) cases per 100 000 person-years for squamous cell carcinoma, 8.76 (95% CI, 7.50-10.02) cases per 100 000 person-years for melanoma, and 0.28 (95% CI, 0.15-0.40) cases per 100 000 person-years for Merkel cell carcinoma. CONCLUSIONS: The registration methodology normally used by cancer registries probably underestimates the incidence rates of basal cell and squamous cell carcinoma in Spain. The incidence rates of cutaneous melanoma and Merkel cell carcinoma are lower in Spain than in other European countries.
INTRODUCTION AND OBJECTIVES: The aim of this systematic review was to describe the incidence and mortality of basal cell carcinoma, squamous cell carcinoma, melanoma, and Merkel cell carcinoma in Spain. MATERIAL AND METHODS: We performed a search of the MEDLINE and Embase databases and reviewed articles from the Spanish Network of Cancer Registries (REDECAN) and the International Agency for Research on Cancer (IARC). The methodological quality of the studies was evaluated and statistical heterogeneity was measured using the I(2) index. A random-effects model was used to perform the meta-analysis because of the heterogeneity of the data. RESULTS: Thirty-two papers were included in the systematic review. The crude incidence rate for basal cell carcinoma was 113.05 (95% CI, 89.03-137.08) cases per 100 000 person-years for the studies based on the registration methodology normally used by registries (in which only 1 tumor with histological confirmation is counted per person). However, the same incidence rate calculated on the basis of clinical and histologic criteria and counting tumors rather than individual patients was 253.23 (95% CI, 273.01-269.45) cases per 100 000 person-years. The incidence was 38.16 (95% CI, 31.72-39.97) cases per 100 000 person-years for squamous cell carcinoma, 8.76 (95% CI, 7.50-10.02) cases per 100 000 person-years for melanoma, and 0.28 (95% CI, 0.15-0.40) cases per 100 000 person-years for Merkel cell carcinoma. CONCLUSIONS: The registration methodology normally used by cancer registries probably underestimates the incidence rates of basal cell and squamous cell carcinoma in Spain. The incidence rates of cutaneous melanoma and Merkel cell carcinoma are lower in Spain than in other European countries.
Authors: A Tejera-Vaquerizo; J Cañueto; A Toll; J Santos-Juanes; A Jaka; C Ferrandiz; O Sanmartín; S Ribero; D Moreno-Ramírez; F Almazán; M J Fuente; S Podlipnik; E Nagore Journal: Actas Dermosifiliogr Date: 2020-09-20
Authors: Mackenzie R Wehner; Wilmarie Cidre Serrano; Adi Nosrati; Patrick Michael Schoen; Mary-Margaret Chren; John Boscardin; Eleni Linos Journal: J Am Acad Dermatol Date: 2017-11-13 Impact factor: 11.527
Authors: Alejandra Tomás-Velázquez; Onofre Sanmartin-Jiménez; Joan R Garcés; Manuel A Rodríguez-Prieto; Verónica Ruiz-Salas; Esther De Eusebio-Murillo; Román Miñano-Medrano; Begoña Escutia-Muñoz; Ángeles Flórez-Menéndez; Juan L Artola-Igarza; Alberto Alfaro-Rubio; Pilar Gil; Yolanda Delgado-Jiménez; Julia M Sanchez-Schmidt; Irati Allende-Markixana; María L Alonso-Pacheco; Beatriz García-Bracamonte; Pablo De la Cueva-Dobao; Raquel Navarro-Tejedor; Cristina Ciudad-Blanco; Lucía Carnero-González; Hugo Vázquez-Veiga; Natividad Cano-Martínez; Eva Vilarrasa-Rull; Pedro Sanchez-Sambucety; José L López-Estebaranz; Rafael Botella-Estrada; Beatriz Gonzalez-Sixto; Antonio Martorell-Calatayud; Victoriano Morales-Gordillo; Agustí Toll-Abelló; Izascun Ocerin-Guerra; Matías Mayor-Arenal; Ricardo Suárez-Fernández; Laura Sainz-Gaspar; Miguel A Descalzo; Ignacio García-Doval; Pedro Redondo Journal: Acta Derm Venereol Date: 2021-11-24 Impact factor: 3.875
Authors: Juan Manuel Gálvez; Daniel Castillo; Luis Javier Herrera; Belén San Román; Olga Valenzuela; Francisco Manuel Ortuño; Ignacio Rojas Journal: PLoS One Date: 2018-05-11 Impact factor: 3.240
Authors: A Tejera-Vaquerizo; J Cañueto; A Toll; J Santos-Juanes; A Jaka; C Ferrandiz-Pulido; O Sanmartín; S Ribero; D Moreno-Ramírez; F Almazán; M J Fuente; S Podlipnik; E Nagore Journal: Actas Dermosifiliogr (Engl Ed) Date: 2020-05-11