| Literature DB >> 26852039 |
Tianbo Jin1,2,3, Bin Li4, Na He1,2,3, Yao Zhang1,2,3, Ridong Xia1,2,3, Longli Kang1,2,3, Yipeng Ding5, Dongya Yuan6,7,8.
Abstract
Variants of the cleft lip and palate trans-membrane 1 like (CLPTM1L) gene, located on chromosome 5p15.33, were previously determined to influence lung cancer susceptibility. Here, we performed a case-control study to examine the potential association of CLPTM1L single nucleotide polymorphisms (SNPs) with lung cancer in a Chinese Han population. We selected four SNPs in the CLPTM1L gene that were previously reported to be associated with lung cancer. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated to estimate the strength of the relationship between each CLPTM1L SNP and lung cancer risk. Allelic model analysis revealed that the minor alleles of all four SNPs were significantly associated with decreased lung cancer risk. Similar significant results were detected using genetic model analysis. In addition, we observed a protective effect of haplotype "TT" in the CLPTM1L gene. Our results verified that certain CLPTM1L polymorphisms are protective factors against lung cancer in a southern Chinese Han population and may be potential diagnostic and molecular markers for lung cancer patients.Entities:
Keywords: CLPTM1L; Case-control study; Lung cancer; Single nucleotide polymorphisms (SNPs)
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Year: 2016 PMID： 26852039 DOI： 10.1007/s13277-016-4938-9
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283