Literature DB >> 18978787

Common 5p15.33 and 6p21.33 variants influence lung cancer risk.

Yufei Wang1, Peter Broderick, Emily Webb, Xifeng Wu, Jayaram Vijayakrishnan, Athena Matakidou, Mobshra Qureshi, Qiong Dong, Xiangjun Gu, Wei Vivien Chen, Margaret R Spitz, Timothy Eisen, Christopher I Amos, Richard S Houlston.   

Abstract

We conducted a genome-wide association (GWA) study of lung cancer comparing 511,919 SNP genotypes in 1,952 cases and 1,438 controls. The most significant association was attained at 15q25.1 (rs8042374; P = 7.75 x 10(-12)), confirming recent observations. Pooling data with two other GWA studies (5,095 cases, 5,200 controls) and with replication in an additional 2,484 cases and 3,036 controls, we identified two newly associated risk loci mapping to 6p21.33 (rs3117582, BAT3-MSH5; P(combined) = 4.97 x 10(-10)) and 5p15.33 (rs401681, CLPTM1L; P(combined) = 7.90 x 10(-9)).

Entities:  

Mesh：

Year:  2008        PMID： 18978787      PMCID： PMC2695928          DOI： 10.1038/ng.273

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  11 in total

1.  Cohort profile: 1958 British birth cohort (National Child Development Study).

Authors:  Chris Power; Jane Elliott
Journal:  Int J Epidemiol       Date:  2005-09-09       Impact factor: 7.196

2.  Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.

Authors:  Christopher I Amos; Xifeng Wu; Peter Broderick; Ivan P Gorlov; Jian Gu; Timothy Eisen; Qiong Dong; Qing Zhang; Xiangjun Gu; Jayaram Vijayakrishnan; Kate Sullivan; Athena Matakidou; Yufei Wang; Gordon Mills; Kimberly Doheny; Ya-Yu Tsai; Wei Vivien Chen; Sanjay Shete; Margaret R Spitz; Richard S Houlston
Journal:  Nat Genet       Date:  2008-04-02       Impact factor: 38.330

3.  A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis.

Authors:  K Yamamoto; A Okamoto; S Isonishi; K Ochiai; Y Ohtake
Journal:  Biochem Biophys Res Commun       Date:  2001-02-02       Impact factor: 3.575

4.  HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53.

Authors:  Toru Sasaki; Eugene C Gan; Andrew Wakeham; Sally Kornbluth; Tak W Mak; Hitoshi Okada
Journal:  Genes Dev       Date:  2007-04-01       Impact factor: 11.361

5.  Microsatellite instability at AAAG repeat sequences in respiratory tract cancers.

Authors:  L Xu; J Chow; J Bonacum; C Eisenberger; S A Ahrendt; M Spafford; L Wu; S M Lee; S Piantadosi; M S Tockman; D Sidransky; J Jen
Journal:  Int J Cancer       Date:  2001-01-15       Impact factor: 7.396

6.  Frequent microsatellite instability in lung cancer from chromate-exposed workers.

Authors:  Toshiyuki Hirose; Kazuya Kondo; Yuji Takahashi; Hisashi Ishikura; Haruhiko Fujino; Masaru Tsuyuguchi; Masato Hashimoto; Tomoyuki Yokose; Kiyoshi Mukai; Tetsurou Kodama; Yasumasa Monden
Journal:  Mol Carcinog       Date:  2002-03       Impact factor: 4.784

7.  Inherited predisposition to early onset lung cancer according to histological type.

Authors:  Xinjun Li; Kari Hemminki
Journal:  Int J Cancer       Date:  2004-11-10       Impact factor: 7.396

8.  A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.

Authors:  Rayjean J Hung; James D McKay; Valerie Gaborieau; Paolo Boffetta; Mia Hashibe; David Zaridze; Anush Mukeria; Neonilia Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Dana Mates; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Chu Chen; Gary Goodman; John K Field; Triantafillos Liloglou; George Xinarianos; Adrian Cassidy; John McLaughlin; Geoffrey Liu; Steven Narod; Hans E Krokan; Frank Skorpen; Maiken Bratt Elvestad; Kristian Hveem; Lars Vatten; Jakob Linseisen; Françoise Clavel-Chapelon; Paolo Vineis; H Bas Bueno-de-Mesquita; Eiliv Lund; Carmen Martinez; Sheila Bingham; Torgny Rasmuson; Pierre Hainaut; Elio Riboli; Wolfgang Ahrens; Simone Benhamou; Pagona Lagiou; Dimitrios Trichopoulos; Ivana Holcátová; Franco Merletti; Kristina Kjaerheim; Antonio Agudo; Gary Macfarlane; Renato Talamini; Lorenzo Simonato; Ray Lowry; David I Conway; Ariana Znaor; Claire Healy; Diana Zelenika; Anne Boland; Marc Delepine; Mario Foglio; Doris Lechner; Fumihiko Matsuda; Helene Blanche; Ivo Gut; Simon Heath; Mark Lathrop; Paul Brennan
Journal:  Nature       Date:  2008-04-03       Impact factor: 49.962

9.  A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.

Authors:  Thorgeir E Thorgeirsson; Frank Geller; Patrick Sulem; Thorunn Rafnar; Anna Wiste; Kristinn P Magnusson; Andrei Manolescu; Gudmar Thorleifsson; Hreinn Stefansson; Andres Ingason; Simon N Stacey; Jon T Bergthorsson; Steinunn Thorlacius; Julius Gudmundsson; Thorlakur Jonsson; Margret Jakobsdottir; Jona Saemundsdottir; Olof Olafsdottir; Larus J Gudmundsson; Gyda Bjornsdottir; Kristleifur Kristjansson; Halla Skuladottir; Helgi J Isaksson; Tomas Gudbjartsson; Gregory T Jones; Thomas Mueller; Anders Gottsäter; Andrea Flex; Katja K H Aben; Femmie de Vegt; Peter F A Mulders; Dolores Isla; Maria J Vidal; Laura Asin; Berta Saez; Laura Murillo; Thorsteinn Blondal; Halldor Kolbeinsson; Jon G Stefansson; Ingunn Hansdottir; Valgerdur Runarsdottir; Roberto Pola; Bengt Lindblad; Andre M van Rij; Benjamin Dieplinger; Meinhard Haltmayer; Jose I Mayordomo; Lambertus A Kiemeney; Stefan E Matthiasson; Hogni Oskarsson; Thorarinn Tyrfingsson; Daniel F Gudbjartsson; Jeffrey R Gulcher; Steinn Jonsson; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Nature       Date:  2008-04-03       Impact factor: 49.962

10.  Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer.

Authors:  Ji Un Kang; Sun Hoe Koo; Kye Chul Kwon; Jong Woo Park; Jin Man Kim
Journal:  Cancer Genet Cytogenet       Date:  2008-04-01
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  305 in total

1.  Germ line variation in nucleotide excision repair genes and lung cancer risk in smokers.

Authors:  Lori C Sakoda; Melissa M Loomis; Jennifer A Doherty; Liberto Julianto; Matt J Barnett; Marian L Neuhouser; Mark D Thornquist; Noel S Weiss; Gary E Goodman; Chu Chen
Journal:  Int J Mol Epidemiol Genet       Date:  2012-02-05

2.  Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium.

Authors:  Rémi Kazma; Marie-Claude Babron; Valérie Gaborieau; Emmanuelle Génin; Paul Brennan; Rayjean J Hung; John R McLaughlin; Hans E Krokan; Maiken B Elvestad; Frank Skorpen; Endre Anderssen; Tõnu Vooder; Kristjan Välk; Andres Metspalu; John K Field; Mark Lathrop; Alain Sarasin; Simone Benhamou
Journal:  Carcinogenesis       Date:  2012-03-01       Impact factor: 4.944

3.  Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck.

Authors:  Zhensheng Liu; Guojun Li; Sheng Wei; Jiangong Niu; Li-E Wang; Erich M Sturgis; Qingyi Wei
Journal:  Carcinogenesis       Date:  2010-08-28       Impact factor: 4.944

4.  Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.

Authors:  Therese Truong; Rayjean J Hung; Christopher I Amos; Xifeng Wu; Heike Bickeböller; Albert Rosenberger; Wiebke Sauter; Thomas Illig; H-Erich Wichmann; Angela Risch; Hendrik Dienemann; Rudolph Kaaks; Ping Yang; Ruoxiang Jiang; John K Wiencke; Margaret Wrensch; Helen Hansen; Karl T Kelsey; Keitaro Matsuo; Kazuo Tajima; Ann G Schwartz; Angie Wenzlaff; Adeline Seow; Chen Ying; Andrea Staratschek-Jox; Peter Nürnberg; Erich Stoelben; Jürgen Wolf; Philip Lazarus; Joshua E Muscat; Carla J Gallagher; Shanbeh Zienolddiny; Aage Haugen; Henricus F M van der Heijden; Lambertus A Kiemeney; Dolores Isla; Jose Ignacio Mayordomo; Thorunn Rafnar; Kari Stefansson; Zuo-Feng Zhang; Shen-Chih Chang; Jin Hee Kim; Yun-Chul Hong; Eric J Duell; Angeline S Andrew; Flavio Lejbkowicz; Gad Rennert; Heiko Müller; Hermann Brenner; Loïc Le Marchand; Simone Benhamou; Christine Bouchardy; M Dawn Teare; Xiaoyan Xue; John McLaughlin; Geoffrey Liu; James D McKay; Paul Brennan; Margaret R Spitz
Journal:  J Natl Cancer Inst       Date:  2010-06-14       Impact factor: 13.506

5.  Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study.

Authors:  Manuela Gago-Dominguez; Xuejuan Jiang; David V Conti; Jose Esteban Castelao; Mariana C Stern; Victoria K Cortessis; Malcolm C Pike; Yong-Bing Xiang; Yu-Tang Gao; Jian-Min Yuan; David J Van Den Berg
Journal:  Carcinogenesis       Date:  2010-11-15       Impact factor: 4.944

6.  Admixture mapping of lung cancer in 1812 African-Americans.

Authors:  Ann G Schwartz; Angela S Wenzlaff; Cathryn H Bock; Julie J Ruterbusch; Wei Chen; Michele L Cote; Amanda S Artis; Alison L Van Dyke; Susan J Land; Curtis C Harris; Sharon R Pine; Margaret R Spitz; Christopher I Amos; Albert M Levin; Paul M McKeigue
Journal:  Carcinogenesis       Date:  2010-11-29       Impact factor: 4.944

7.  Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations.

Authors:  Daiki Miki; Michiaki Kubo; Atsushi Takahashi; Kyong-Ah Yoon; Jeongseon Kim; Geon Kook Lee; Jae Ill Zo; Jin Soo Lee; Naoya Hosono; Takashi Morizono; Tatsuhiko Tsunoda; Naoyuki Kamatani; Kazuaki Chayama; Takashi Takahashi; Johji Inazawa; Yusuke Nakamura; Yataro Daigo
Journal:  Nat Genet       Date:  2010-09-26       Impact factor: 38.330

8.  Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity.

Authors:  Porat M Erlich; Stuart N Hoffman; Margaret Rukstalis; John J Han; Xin Chu; W H Linda Kao; Glenn S Gerhard; Walter F Stewart; Joseph A Boscarino
Journal:  Hum Genet       Date:  2010-08-20       Impact factor: 4.132

9.  A genome-wide gene-gene interaction analysis identifies an epistatic gene pair for lung cancer susceptibility in Han Chinese.

Authors:  Minjie Chu; Ruyang Zhang; Yang Zhao; Chen Wu; Huan Guo; Baosen Zhou; Jiachun Lu; Yongyong Shi; Juncheng Dai; Guangfu Jin; Hongxia Ma; Jing Dong; Yongyue Wei; Cheng Wang; Jianhang Gong; Chongqi Sun; Meng Zhu; Yongyong Qiu; Tangchun Wu; Zhibin Hu; Dongxin Lin; Hongbing Shen; Feng Chen
Journal:  Carcinogenesis       Date:  2013-12-09       Impact factor: 4.944

Review 10.  The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects.

Authors:  Anne M Molloy; Lawrence C Brody; James L Mills; John M Scott; Peadar N Kirke
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2009-04
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