Literature DB >> 26852022

Combinatorial synthesis of deuterium-enriched (S)-oxybutynin.

Feng Li1,2, Wenfeng Jiang1,2, Anthony W Czarnik3, Wenbao Li4,5.   

Abstract

The concept of deuterium enrichment has gained more attention due to its advantages in the studies of clinical pharmacokinetics and metabolic profiles. In addition, it is cost and time efficient to develop deuterium-enriched drugs. Herein we built a combinatorial library of deuterated (S)-oxybutynins which all 8 D-compounds were characterized by MS, [Formula: see text] NMR and [Formula: see text]C NMR.

Entities:  

Keywords:  Combinatorial chemistry; Derivatives; Deuterium; Oxybutynin

Mesh：

Substances：

Year:  2016        PMID： 26852022     DOI： 10.1007/s11030-016-9660-4

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  8 in total

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Authors:  S Radajewski; P Ineson; N R Parekh; J C Murrell
Journal:  Nature       Date:  2000-02-10       Impact factor: 49.962

Review 2.  The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity.

Authors:  Sidney D Nelson; William F Trager
Journal:  Drug Metab Dispos       Date:  2003-12       Impact factor: 3.922

3.  Aminoalkynyldithianes. A new class of calcium channel blockers.

Authors:  T C Adams; A C Dupont; J P Carter; J F Kachur; M E Guzewska; W J Rzeszotarski; S G Farmer; L Noronha-Blob; C Kaiser
Journal:  J Med Chem       Date:  1991-05       Impact factor: 7.446

4.  Stable isotope constraints on Holocene carbon cycle changes from an Antarctic ice core.

Authors:  Joachim Elsig; Jochen Schmitt; Daiana Leuenberger; Robert Schneider; Marc Eyer; Markus Leuenberger; Fortunat Joos; Hubertus Fischer; Thomas F Stocker
Journal:  Nature       Date:  2009-09-24       Impact factor: 49.962

5.  Using deuterium in drug discovery: leaving the label in the drug.

Authors:  Thomas G Gant
Journal:  J Med Chem       Date:  2013-12-02       Impact factor: 7.446

6.  Expression, purification, assay, and crystal structure of perdeuterated human arginase I.

Authors:  Luigi Di Costanzo; Martine Moulin; Michael Haertlein; Flora Meilleur; David W Christianson
Journal:  Arch Biochem Biophys       Date:  2007-05-21       Impact factor: 4.013

7.  Deuterium oxide effect on temperature-dependent survival in populations of Drosophila melanogaster.

Authors:  H V Samis; M B Baird; H R Massie
Journal:  Science       Date:  1974-02-01       Impact factor: 47.728

8.  The preparation and human muscarinic receptor profiling of oxybutynin and N-desethyloxybutynin enantiomers.

Authors:  Allen B Reitz; Suneel K Gupta; Yifang Huang; Michael H Parker; Richard R Ryan
Journal:  Med Chem       Date:  2007-11       Impact factor: 2.745
  8 in total

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