Eduardo A Novais1, Mehreen Adhi2, Eric M Moult3, Ricardo N Louzada4, Emily D Cole2, Lennart Husvogt5, ByungKun Lee3, Sabin Dang6, Caio V S Regatieri1, André J Witkin6, Caroline R Baumal6, Joachim Hornegger7, Vijaysekhar Jayaraman8, James G Fujimoto3, Jay S Duker6, Nadia K Waheed9. 1. New England Eye Center, Tufts Medical Center, Boston, Massachusetts; Federal University of São Paulo, School of Medicine, São Paulo, Brazil. 2. New England Eye Center, Tufts Medical Center, Boston, Massachusetts; Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts. 3. Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts. 4. New England Eye Center, Tufts Medical Center, Boston, Massachusetts; Federal University of Goiás, Goiânia, Brazil. 5. Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts; Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. 6. New England Eye Center, Tufts Medical Center, Boston, Massachusetts. 7. Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany; Erlangen Graduate School in Advanced Optical Technologies (SAOT), Erlangen, Germany. 8. Praevium Research Inc, Santa Barbara, California. 9. New England Eye Center, Tufts Medical Center, Boston, Massachusetts. Electronic address: nadiakwaheed@gmail.com.
Abstract
PURPOSE: To compare visualization of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) using an ultrahigh-speed swept-source (SS) optical coherence tomography angiography (OCTA) prototype vs a spectral-domain (SD) OCTA device. DESIGN: Comparative analysis of diagnostic instruments. METHODS: Patients were prospectively recruited to be imaged on SD OCT and SS OCT devices on the same day. The SD OCT device employed is the RTVue Avanti (Optovue, Inc, Fremont, California, USA), which operates at ∼840 nm wavelength and 70 000 A-scans/second. The SS OCT device used is an ultrahigh-speed long-wavelength prototype that operates at ∼1050 nm wavelength and 400 000 A-scans/second. Two observers independently measured the CNV area on OCTA en face images from the 2 devices. The nonparametric Wilcoxon signed rank test was used to compare area measurements and P values of <.05 were considered statistically significant. RESULTS: Fourteen eyes from 13 patients were enrolled. The CNV in 11 eyes (78.6%) were classified as type 1, 2 eyes (14.3%) as type 2, and 1 eye (7.1%) as mixed type. Total CNV area measured using SS OCT and SD OCT 3 mm × 3 mm OCTA were 0.949 ± 1.168 mm(2) and 0.340 ± 0.301 mm(2), respectively (P = .001). For the 6 mm × 6 mm OCTA the total CNV area using SS OCT and SD OCT were 1.218 ± 1.284 mm(2) and 0.604 ± 0.597 mm(2), respectively (P = .0019). The field of view did not significantly affect the measured CNV area (P = .19 and P = .18 for SS OCT and SD OCT, respectively). CONCLUSION: SS OCTA yielded significantly larger CNV areas than SD OCTA. It is possible that SS OCTA is better able to demarcate the full extent of CNV vasculature.
PURPOSE: To compare visualization of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) using an ultrahigh-speed swept-source (SS) optical coherence tomography angiography (OCTA) prototype vs a spectral-domain (SD) OCTA device. DESIGN: Comparative analysis of diagnostic instruments. METHODS:Patients were prospectively recruited to be imaged on SD OCT and SSOCT devices on the same day. The SD OCT device employed is the RTVue Avanti (Optovue, Inc, Fremont, California, USA), which operates at ∼840 nm wavelength and 70 000 A-scans/second. The SSOCT device used is an ultrahigh-speed long-wavelength prototype that operates at ∼1050 nm wavelength and 400 000 A-scans/second. Two observers independently measured the CNV area on OCTA en face images from the 2 devices. The nonparametric Wilcoxon signed rank test was used to compare area measurements and P values of <.05 were considered statistically significant. RESULTS: Fourteen eyes from 13 patients were enrolled. The CNV in 11 eyes (78.6%) were classified as type 1, 2 eyes (14.3%) as type 2, and 1 eye (7.1%) as mixed type. Total CNV area measured using SSOCT and SD OCT 3 mm × 3 mm OCTA were 0.949 ± 1.168 mm(2) and 0.340 ± 0.301 mm(2), respectively (P = .001). For the 6 mm × 6 mm OCTA the total CNV area using SSOCT and SD OCT were 1.218 ± 1.284 mm(2) and 0.604 ± 0.597 mm(2), respectively (P = .0019). The field of view did not significantly affect the measured CNV area (P = .19 and P = .18 for SSOCT and SD OCT, respectively). CONCLUSION:SSOCTA yielded significantly larger CNV areas than SD OCTA. It is possible that SSOCTA is better able to demarcate the full extent of CNV vasculature.
Authors: Boris Povazay; Boris Hermann; Angelika Unterhuber; Bernd Hofer; Harald Sattmann; Florian Zeiler; James E Morgan; Christiane Falkner-Radler; Carl Glittenberg; Susanne Blinder; Wolfgang Drexler Journal: J Biomed Opt Date: 2007 Jul-Aug Impact factor: 3.170
Authors: Andrea Giani; Cristiano Luiselli; Daniel D Esmaili; Paola Salvetti; Mario Cigada; Joan W Miller; Giovanni Staurenghi Journal: Invest Ophthalmol Vis Sci Date: 2011-07-29 Impact factor: 4.799
Authors: Mehreen Adhi; Jonathan J Liu; Ahmed H Qavi; Ireneusz Grulkowski; Chen D Lu; Kathrin J Mohler; Daniela Ferrara; Martin F Kraus; Caroline R Baumal; Andre J Witkin; Nadia K Waheed; Joachim Hornegger; James G Fujimoto; Jay S Duker Journal: Am J Ophthalmol Date: 2014-02-18 Impact factor: 5.258
Authors: Talisa E de Carlo; Marco A Bonini Filho; Adam T Chin; Mehreen Adhi; Daniela Ferrara; Caroline R Baumal; Andre J Witkin; Elias Reichel; Jay S Duker; Nadia K Waheed Journal: Ophthalmology Date: 2015-03-17 Impact factor: 12.079
Authors: Daniel M de Bruin; Daina L Burnes; John Loewenstein; Yueli Chen; Susie Chang; Teresa C Chen; Daniel D Esmaili; Johannes F de Boer Journal: Invest Ophthalmol Vis Sci Date: 2008-04-04 Impact factor: 4.799
Authors: Jin Yang; Qinqin Zhang; Elie H Motulsky; Marie Thulliez; Yingying Shi; Cancan Lyu; Luis de Sisternes; Mary K Durbin; William Feuer; Ruikang K Wang; Giovanni Gregori; Philip J Rosenfeld Journal: Am J Ophthalmol Date: 2019-06-21 Impact factor: 5.258
Authors: Lennart Husvogt; Stefan B Ploner; Siyu Chen; Daniel Stromer; Julia Schottenhamml; A Yasin Alibhai; Eric Moult; Nadia K Waheed; James G Fujimoto; Andreas Maier Journal: Biomed Opt Express Date: 2020-12-07 Impact factor: 3.732
Authors: Carl B Rebhun; Eric M Moult; Stefan B Ploner; Carlos Moreira Neto; A Yasin Alibhai; Julia Schottenhamml; Byungkun Lee; WooJhon Choi; Fareed A Rifai; Mary W Tam; Lennart Husvogt; Caroline R Baumal; Andre J Witkin; Andreas Maier; Philip J Rosenfeld; Jay S Duker; James G Fujimoto; Nadia K Waheed Journal: Ophthalmol Retina Date: 2017-10-31
Authors: Yasuo Yanagi; Aditi Mohla; Shu Yen Lee; Ranjana Mathur; Choi Mun Chan; Ian Yeo; Tien Yin Wong; Chui Ming Gemmy Cheung Journal: JAMA Ophthalmol Date: 2018-08-01 Impact factor: 7.389