Literature DB >> 26850569

Implementation of a pharmacogenomics consult service to support the INGENIOUS trial.

M T Eadon1, Z Desta1, K D Levy1, B S Decker1, R C Pierson1, V M Pratt2, J T Callaghan1,3, M B Rosenman4, J S Carpenter5, A M Holmes6, C A McDonald1, E A Benson1, A S Patil1,7, R Vuppalanchi1, B T Gufford1, N Dave1, J D Robarge1, M A Hyder1, D M Haas7, R P Kreutz1, P R Dexter8, T C Skaar1, D A Flockhart1.   

Abstract

Hospital systems increasingly utilize pharmacogenomic testing to inform clinical prescribing. Successful implementation efforts have been modeled at many academic centers. In contrast, this report provides insights into the formation of a pharmacogenomics consultation service at a safety-net hospital, which predominantly serves low-income, uninsured, and vulnerable populations. The report describes the INdiana GENomics Implementation: an Opportunity for the UnderServed (INGENIOUS) trial and addresses concerns of adjudication, credentialing, and funding.
© 2016 American Society for Clinical Pharmacology and Therapeutics.

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Year:  2016        PMID: 26850569      PMCID: PMC4899152          DOI: 10.1002/cpt.347

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN: 0009-9236            Impact factor:   6.875


  5 in total

1.  Development and implementation of a pharmacist-managed clinical pharmacogenetics service.

Authors:  Kristine R Crews; Shane J Cross; John N McCormick; Donald K Baker; Alejandro R Molinelli; Richard Mullins; Mary V Relling; James M Hoffman
Journal:  Am J Health Syst Pharm       Date:  2011-01-15       Impact factor: 2.637

2.  Adoption of a clinical pharmacogenomics implementation program during outpatient care--initial results of the University of Chicago "1,200 Patients Project".

Authors:  Peter H O'Donnell; Keith Danahey; Michael Jacobs; Nisha R Wadhwa; Shennin Yuen; Angela Bush; Yasmin Sacro; Matthew J Sorrentino; Mark Siegler; William Harper; Andrea Warrick; Soma Das; Don Saner; Christopher L Corless; Mark J Ratain
Journal:  Am J Med Genet C Semin Med Genet       Date:  2014-03-10       Impact factor: 3.908

3.  The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation.

Authors:  A R Shuldiner; M V Relling; J F Peterson; J K Hicks; R R Freimuth; W Sadee; N L Pereira; D M Roden; J A Johnson; T E Klein; Alan R Shuldiner; Mark Vesely; Shawn W Robinson; Nicholas Ambulos; Sanford A Stass; Mark D Kelemen; Lawrence A Brown; Toni I Pollin; Amber L Beitelshees; Richard Y Zhao; Ruth E Pakyz; Kathleen Palmer; Tameka Alestock; Courtney O'Neill; Kristin Maloney; Amie Branham; Danielle Sewell; Mary V Relling; Kristine Crews; James Hoffman; Shane Cross; Cyrine Haidar; Don Baker; J Kevin Hicks; Gillian Bell; Fran Greeson; Aditya Gaur; Ulrike Reiss; Alicia Huettel; Cheng Cheng; Amar Gajjar; Alberto Pappo; Scott Howard; Melissa Hudson; Ching-Hon Pui; Sima Jeha; William E Evans; Ulrich Broeckel; Russ B Altman; Li Gong; Michelle Whirl-Carrillo; Teri E Klein; Wolfgang Sadee; Kandamurugu Manickam; Kevin M Sweet; Peter J Embi; Dan Roden; Josh Peterson; Josh Denny; Jonathan Schildcrout; Erica Bowton; Jill Pulley; Marc Beller; Jennifer Mitchell; Ioana Danciu; Lisa Price; Naveen L Pereira; Richard Weinshilboum; Liewei Wang; Julie A Johnson; David Nelson; Michael Clare-Salzler; Amanda Elsey; Benjamin Burkley; Taimour Langaee; Felix Liu; David Nessl; Hui-Jia Dong; Larry Lesko; Robert R Freimuth; Christopher G Chute
Journal:  Clin Pharmacol Ther       Date:  2013-03-19       Impact factor: 6.875

4.  Prerequisites to implementing a pharmacogenomics program in a large health-care system.

Authors:  K D Levy; B S Decker; J S Carpenter; D A Flockhart; P R Dexter; Z Desta; T C Skaar
Journal:  Clin Pharmacol Ther       Date:  2014-05-07       Impact factor: 6.875

5.  Electronic health record design and implementation for pharmacogenomics: a local perspective.

Authors:  Josh F Peterson; Erica Bowton; Julie R Field; Marc Beller; Jennifer Mitchell; Jonathan Schildcrout; William Gregg; Kevin Johnson; Jim N Jirjis; Dan M Roden; Jill M Pulley; Josh C Denny
Journal:  Genet Med       Date:  2013-09-05       Impact factor: 8.822

  5 in total
  24 in total

1.  Role of genetics in the prediction of statin-associated muscle symptoms and optimization of statin use and adherence.

Authors:  Liam R Brunham; Steven Baker; Andrew Mammen; G B John Mancini; Robert S Rosenson
Journal:  Cardiovasc Res       Date:  2018-07-01       Impact factor: 10.787

2.  Introducing pharmacogenetic testing with clinical decision support into primary care: a feasibility study.

Authors:  Martin Dawes; Martin N Aloise; J Sidney Ang; Pieter Cullis; Diana Dawes; Robert Fraser; Gideon Liknaitzky; Andrea Paterson; Paul Stanley; Adriana Suarez-Gonzalez; Hagit Katzov-Eckert
Journal:  CMAJ Open       Date:  2016-09-21

3.  Impact of SLCO1B1 Pharmacogenetic Testing on Patient and Healthcare Outcomes: A Systematic Review.

Authors:  Jason L Vassy; Sojeong Chun; Sanjay Advani; Sophie A Ludin; Jason G Smith; Elaine C Alligood
Journal:  Clin Pharmacol Ther       Date:  2018-10-18       Impact factor: 6.875

Review 4.  Complex Drug-Drug-Gene-Disease Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical Perspectives.

Authors:  Flavia Storelli; Caroline Samer; Jean-Luc Reny; Jules Desmeules; Youssef Daali
Journal:  Clin Pharmacokinet       Date:  2018-10       Impact factor: 6.447

5.  Pharmacogenetics and Practice: Tailoring Prescribing for Safety and Effectiveness.

Authors:  Cathy R Fulton; Marelize Swart; Thomas De Luca; Stephanie N Liu; Kimberly S Collins; Zeruesenay Desta; Brandon T Gufford; Michael T Eadon
Journal:  J Nurse Pract       Date:  2018-11-02       Impact factor: 0.767

6.  Clinical and educational impact of pharmacogenomics testing: a case series from the INGENIOUS trial.

Authors:  Rebecca C Pierson; Brandon T Gufford; Zeruesenay Desta; Michael T Eadon
Journal:  Pharmacogenomics       Date:  2017-06-08       Impact factor: 2.533

Review 7.  Precision Medicine at the University of Alabama at Birmingham: Laying the Foundational Processes Through Implementation of Genotype-Guided Antiplatelet Therapy.

Authors:  S Harada; Y Zhou; S Duncan; A R Armstead; G M Coshatt; C Dillon; B C Brott; J Willig; J A Alsip; W B Hillegass; N A Limdi
Journal:  Clin Pharmacol Ther       Date:  2017-06-01       Impact factor: 6.875

8.  Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial.

Authors:  Cathy R Fulton; Yong Zang; Zeruesenay Desta; Marc B Rosenman; Ann M Holmes; Brian S Decker; Yifei Zhang; John T Callaghan; Victoria M Pratt; Kenneth D Levy; Brandon T Gufford; Paul R Dexter; Todd C Skaar; Michael T Eadon
Journal:  Pharmacogenomics       Date:  2019-02-20       Impact factor: 2.533

9.  Pharmacogenomics-Based Point-of-Care Clinical Decision Support Significantly Alters Drug Prescribing.

Authors:  P H O'Donnell; N Wadhwa; K Danahey; B A Borden; S M Lee; J P Hall; C Klammer; S Hussain; M Siegler; M J Sorrentino; A M Davis; Y A Sacro; R Nanda; T S Polonsky; J L Koyner; D L Burnet; K Lipstreuer; D T Rubin; C Mulcahy; M E Strek; W Harper; A S Cifu; B Polite; L Patrick-Miller; K-Tj Yeo; Eky Leung; S L Volchenboum; R B Altman; O I Olopade; W M Stadler; D O Meltzer; M J Ratain
Journal:  Clin Pharmacol Ther       Date:  2017-06-15       Impact factor: 6.875

Review 10.  Strategic vision for improving human health at The Forefront of Genomics.

Authors:  Eric D Green; Chris Gunter; Leslie G Biesecker; Valentina Di Francesco; Carla L Easter; Elise A Feingold; Adam L Felsenfeld; David J Kaufman; Elaine A Ostrander; William J Pavan; Adam M Phillippy; Anastasia L Wise; Jyoti Gupta Dayal; Britny J Kish; Allison Mandich; Christopher R Wellington; Kris A Wetterstrand; Sarah A Bates; Darryl Leja; Susan Vasquez; William A Gahl; Bettie J Graham; Daniel L Kastner; Paul Liu; Laura Lyman Rodriguez; Benjamin D Solomon; Vence L Bonham; Lawrence C Brody; Carolyn M Hutter; Teri A Manolio
Journal:  Nature       Date:  2020-10-28       Impact factor: 49.962

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