Literature DB >> 26848559

Hyperpolarization MRI: Preclinical Models and Potential Applications in Neuroradiology.

Vesselin Z Miloushev1, Kayvan R Keshari, Andrei I Holodny.   

Abstract

Hyperpolarization is a novel technology that can dramatically increase signal to noise in magnetic resonance. The method is being applied to small injectable endogenous molecules, which can be used to monitor transient in vivo metabolic events, in real time. The emergence of hyperpolarized C-labeled probes, specifically C pyruvate, has enabled monitoring of core cellular metabolic events. Neuro-oncological applications have been demonstrated in preclinical models. Many more applications of this technology are envisioned, with transformative potential in magnetic resonance imaging.

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Year:  2016        PMID： 26848559      PMCID： PMC4968075          DOI： 10.1097/RMR.0000000000000076

Source DB:  PubMed          Journal:  Top Magn Reson Imaging        ISSN： 0899-3459


  63 in total

1.  On the origin of cancer cells.

Authors:  O WARBURG
Journal:  Science       Date:  1956-02-24       Impact factor: 47.728

2.  Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma.

Authors:  Myriam M Chaumeil; Tomoko Ozawa; IlWoo Park; Kristen Scott; C David James; Sarah J Nelson; Sabrina M Ronen
Journal:  Neuroimage       Date:  2011-07-23       Impact factor: 6.556

3.  Gliomas are driven by glycolysis: putative roles of hexokinase, oxidative phosphorylation and mitochondrial ultrastructure.

Authors:  S Oudard; E Boitier; L Miccoli; S Rousset; B Dutrillaux; M F Poupon
Journal:  Anticancer Res       Date:  1997 May-Jun       Impact factor: 2.480

4.  Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors.

Authors:  Ferdia A Gallagher; Mikko I Kettunen; De-En Hu; Pernille R Jensen; René In 't Zandt; Magnus Karlsson; Anna Gisselsson; Sarah K Nelson; Timothy H Witney; Sarah E Bohndiek; Georg Hansson; Torben Peitersen; Mathilde H Lerche; Kevin M Brindle
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-10       Impact factor: 11.205

5.  In vivo and in vitro liver cancer metabolism observed with hyperpolarized [5-(13)C]glutamine.

Authors:  C Cabella; M Karlsson; C Canapè; G Catanzaro; S Colombo Serra; L Miragoli; L Poggi; F Uggeri; L Venturi; P R Jensen; M H Lerche; F Tedoldi
Journal:  J Magn Reson       Date:  2013-04-26       Impact factor: 2.229

6.  Imaging considerations for in vivo 13C metabolic mapping using hyperpolarized 13C-pyruvate.

Authors:  Y-F Yen; S J Kohler; A P Chen; J Tropp; R Bok; J Wolber; M J Albers; K A Gram; M L Zierhut; I Park; V Zhang; S Hu; S J Nelson; D B Vigneron; J Kurhanewicz; H A A M Dirven; R E Hurd
Journal:  Magn Reson Med       Date:  2009-07       Impact factor: 4.668

7.  Metabolite kinetics in C6 rat glioma model using magnetic resonance spectroscopic imaging of hyperpolarized [1-(13)C]pyruvate.

Authors:  Jae Mo Park; Sonal Josan; Taichang Jang; Milton Merchant; Yi-Fen Yen; Ralph E Hurd; Lawrence Recht; Daniel M Spielman; Dirk Mayer
Journal:  Magn Reson Med       Date:  2012-02-14       Impact factor: 4.668

Review 8.  The interplay between MYC and HIF in cancer.

Authors:  Chi V Dang; Jung-whan Kim; Ping Gao; Jason Yustein
Journal:  Nat Rev Cancer       Date:  2008-01       Impact factor: 60.716

9.  Distribution of hyperpolarized xenon in the brain following sensory stimulation: preliminary MRI findings.

Authors:  Mary L Mazzanti; Ronn P Walvick; Xin Zhou; Yanping Sun; Niral Shah; Joey Mansour; Jessica Gereige; Mitchell S Albert
Journal:  PLoS One       Date:  2011-07-15       Impact factor: 3.240

10.  (13)C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging.

Authors:  Lucia Salamanca-Cardona; Kayvan R Keshari
Journal:  Cancer Metab       Date:  2015-09-14
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  6 in total

1.  AcidoCEST-UTE MRI for the Assessment of Extracellular pH of Joint Tissues at 3 T.

Authors:  Ya-Jun Ma; Rachel A High; Qingbo Tang; Lidi Wan; Saeed Jerban; Jiang Du; Eric Y Chang
Journal:  Invest Radiol       Date:  2019-09       Impact factor: 6.016

Review 2.  Probing carbohydrate metabolism using hyperpolarized 13 C-labeled molecules.

Authors:  Jaspal Singh; Eul Hyun Suh; Gaurav Sharma; Chalermchai Khemtong; A Dean Sherry; Zoltan Kovacs
Journal:  NMR Biomed       Date:  2018-11-26       Impact factor: 4.044

Review 3.  Molecular fMRI of neurochemical signaling.

Authors:  He Wei; Abigail M Frey; Alan Jasanoff
Journal:  J Neurosci Methods       Date:  2021-09-29       Impact factor: 2.390

4.  Magnetic resonance biomarkers in radiation oncology: The report of AAPM Task Group 294.

Authors:  Kiaran P McGee; Ken-Pin Hwang; Daniel C Sullivan; John Kurhanewicz; Yanle Hu; Jihong Wang; Wen Li; Josef Debbins; Eric Paulson; Jeffrey R Olsen; Chia-Ho Hua; Lizette Warner; Daniel Ma; Eduardo Moros; Neelam Tyagi; Caroline Chung
Journal:  Med Phys       Date:  2021-05-20       Impact factor: 4.071

Review 5.  Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture.

Authors:  Alice P Sowton; Julian L Griffin; Andrew J Murray
Journal:  Front Physiol       Date:  2019-05-31       Impact factor: 4.566

Review 6.  Prostate imaging features that indicate benign or malignant pathology on biopsy.

Authors:  Catherine Elizabeth Lovegrove; Mudit Matanhelia; Jagpal Randeva; David Eldred-Evans; Henry Tam; Saiful Miah; Mathias Winkler; Hashim U Ahmed; Taimur T Shah
Journal:  Transl Androl Urol       Date:  2018-09
  6 in total

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