Literature DB >> 26848411

An Exceptionally Favorable Response to Etoposide and Cisplatin.

Gautam Valecha1, Adarsh Vennepureddy1, Uroosa Ibrahim2, Marcel Odaimi2.   

Abstract

A 66-year-old female with multiple medical co-morbidities was diagnosed with limited-stage small cell lung carcinoma (SCLC) about 11 years ago, back in 2004. The patient was treated with concomitant chemotherapy and radiotherapy, along with prophylactic whole brain radiation. She received a total of four cycles of etoposide and cisplatin. The patient showed a complete response to the above-mentioned treatment and had no evidence of tumor recurrence on any of the scans until 2015. Her last computed tomography (CT) scan of the chest in October 2015 showed bilateral hilar and mediastinal lymphadenopathy. Fine needle aspiration (FNA) of the left hilar node revealed the presence of malignant cells consistent with SCLC. Median survival for limited stage SCLC ranges from 16-24 months, and the reported five-year survival is 14%. In this report, we present the case of a 66-year-old female who showed an exceptionally favorable response to cisplatin and etoposide chemotherapy characterized by a disease-free survival of 11 years.

Entities:  

Keywords:  cisplatin; etoposide; response; sclc; small cell lung carcinoma; survival

Year:  2015        PMID: 26848411      PMCID: PMC4725742          DOI: 10.7759/cureus.418

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  8 in total

1.  Redevelopment of small cell lung cancer after a long disease-free period: a case report.

Authors:  Yoshizumi Kitamoto; Kazushige Hayakawa; Norio Mitsuhashi; Satoshi Tsuchiya; Ryusei Saito
Journal:  Jpn J Clin Oncol       Date:  2002-01       Impact factor: 3.019

2.  Relapse of stage I small cell lung cancer ten or more years after the start of treatment.

Authors:  Kaoru Matsui; Toshiyuki Sawa; Hidekazu Suzuki; Katsuhiro Nakagawa; Norio Okamoto; Takuhito Tada; Teruaki Nagano; Noriyuki Masuda
Journal:  Jpn J Clin Oncol       Date:  2006-06-16       Impact factor: 3.019

Review 3.  Long-term survival in small cell lung cancer: a case report and review of the literature.

Authors:  Alfredo Tartarone; Rosa Lerose; Raffaele Ardito; Laura Troiani; Beatrice Tedesco; Giovanni Bozza; Rodolfo Cangiano; Michele Aieta
Journal:  Future Oncol       Date:  2014-03       Impact factor: 3.404

Review 4.  Ten years of disease-free survival between two diagnoses of small-cell lung cancer: a case report and a literature review.

Authors:  M Al-Ajam; A Seymour; M Mooty; A Leaf
Journal:  Med Oncol       Date:  2005       Impact factor: 3.064

5.  Long-term survival of a patient with small cell lung cancer after nine lines of chemotherapy and radiation.

Authors:  Olav Gressner; Henning Popp; Ulrich Mey; Nicolaus Friedrichs; John Strehl; Tilman Sauerbruch; Ingo G H Schmidt-Wolf; Marcus Gorschlüter
Journal:  Onkologie       Date:  2008-08-15

6.  The incidence of second primary tumors in long-term survivors of small-cell lung cancer.

Authors:  K H Heyne; S M Lippman; J J Lee; J S Lee; W K Hong
Journal:  J Clin Oncol       Date:  1992-10       Impact factor: 44.544

Review 7.  Long-term survival of a patient with small cell lung cancer associated with cancer-associated retinopathy.

Authors:  Makoto Kobayashi; Takayuki Ikezoe; Yoshiki Uemura; Hisayuki Ueno; Hirokuni Taguchi
Journal:  Lung Cancer       Date:  2007-03-29       Impact factor: 5.705

8.  Long-term survival in small-cell lung cancer: posttreatment characteristics in patients surviving 5 to 18+ years--an analysis of 1,714 consecutive patients.

Authors:  U Lassen; K Osterlind; M Hansen; P Dombernowsky; B Bergman; H H Hansen
Journal:  J Clin Oncol       Date:  1995-05       Impact factor: 44.544

  8 in total

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