Literature DB >> 2684796

Endogenous oxidative DNA damage, aging, and cancer.

B N Ames1.   

Abstract

Progress in identifying the important endogenous processes damaging DNA and developing methods to assay this damage in individuals is presented. This approach may aid studies on modulation of cancer and aging. The endogenous background level of oxidant-induced DNA damage in vivo has been assayed by measuring 8-hydroxydeoxyguanosine (oh8dG), thymine glycol and thymidine glycol in urine and oh8dG in DNA. oh8dG is one of about 20 adducts found on oxidizing DNA, e.g., by radiation. The level of oxidative DNA damage as measured by oh8dG in normal rat liver is shown to be extensive, especially in mtDNA (1/130,000 bases in nuclear DNA and 1/8,000 bases in mitochondrial DNA). We also discuss three hitherto unrecognized antioxidants in man.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2684796     DOI： 10.3109/10715768909087933

Source DB:  PubMed          Journal:  Free Radic Res Commun        ISSN： 8755-0199


  119 in total

1.  Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells.

Authors:  L J Wu; G Randers-Pehrson; A Xu; C A Waldren; C R Geard; Z Yu; T K Hei
Journal:  Proc Natl Acad Sci U S A       Date:  1999-04-27       Impact factor: 11.205

2.  Release of mitochondrial apoptogenic factors and cell death are mediated by CK2 and NADPH oxidase.

Authors:  Gab Seok Kim; Joo Eun Jung; Purnima Narasimhan; Hiroyuki Sakata; Hideyuki Yoshioka; Yun Seon Song; Nobuya Okami; Pak H Chan
Journal:  J Cereb Blood Flow Metab       Date:  2011-12-07       Impact factor: 6.200

3.  Long-term adaptation of the human lung tumor cell line A549 to increasing concentrations of hydrogen peroxide.

Authors:  Abdullah Onul; Kim M Elseth; Humberto De Vitto; William A Paradise; Benjamin J Vesper; Gabor Tarjan; G Kenneth Haines; Franklin D Rumjanek; James A Radosevich
Journal:  Tumour Biol       Date:  2012-03-10

4.  Detection of a specific mitochondrial DNA deletion in tissues of older humans.

Authors:  G A Cortopassi; N Arnheim
Journal:  Nucleic Acids Res       Date:  1990-12-11       Impact factor: 16.971

Review 5.  DNA damage and its processing. relation to human disease.

Authors:  V A Bohr
Journal:  J Inherit Metab Dis       Date:  2002-05       Impact factor: 4.982

6.  Nature's chemicals and synthetic chemicals: comparative toxicology.

Authors:  B N Ames; M Profet; L S Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

7.  Sex-specific SOD levels and DNA damage in painted dragon lizards (Ctenophorus pictus).

Authors:  Mats Olsson; Mo Healey; Cecile Perrin; Mark Wilson; Michael Tobler
Journal:  Oecologia       Date:  2012-06-15       Impact factor: 3.225

8.  Expression profile of DNA damage signaling genes in 2 Gy proton exposed mouse brain.

Authors:  Sudhakar Baluchamy; Ye Zhang; Prabakaran Ravichandran; Vani Ramesh; Ayodotun Sodipe; Joseph C Hall; Olufisayo Jejelowo; Daila S Gridley; Honglu Wu; Govindarajan T Ramesh
Journal:  Mol Cell Biochem       Date:  2010-04-11       Impact factor: 3.396

9.  Antioxidant properties of dehydrozingerone and curcumin in rat brain homogenates.

Authors:  D V Rajakumar; M N Rao
Journal:  Mol Cell Biochem       Date:  1994-11-09       Impact factor: 3.396

10.  Overexpression of thioredoxin-1 reduces oxidative stress in the placenta of transgenic mice and promotes fetal growth via glucose metabolism.

Authors:  Takashi Umekawa; Takashi Sugiyama; Tomohisa Kihira; Nao Murabayashi; Lingyun Zhang; Kenji Nagao; Yuki Kamimoto; Ning Ma; Junji Yodoi; Norimasa Sagawa
Journal:  Endocrinology       Date:  2008-05-01       Impact factor: 4.736
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.