Eline C Soer1, Laura W Leicher2, Alexandra M J Langers3, Paul C van de Meeberg4, Egbert-Jan van der Wouden2, Jan Jakob Koornstra5, Marloes Bigirwamungu-Bargeman6, Hans F A Vasen7, Wouter H de Vos tot Nederveen Cappel2. 1. Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands. e.c.soer@amc.uva.nl. 2. Department of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands. 3. Department of Gastroenterology and Hepatology, Leiden University Medical Center, Isala Clinics, P.O. box 10400, 8000 GK, Zwolle, The Netherlands. 4. Department of Gastroenterology and Hepatology, Slingeland Ziekenhuis, Doetinchem, The Netherlands. 5. Department of Gastroenterology and Hepatology, Groningen University Medical Center, Groningen, The Netherlands. 6. Department of Gastroenterology and Hepatology, Medisch Spectrum Twente, Enschede, The Netherlands. 7. The Netherlands Foundation for the Detection of Hereditary Tumors, Leiden, The Netherlands.
Abstract
BACKGROUND: Patients with Lynch syndrome (LS) are at an increased risk of developing gastric cancer. In 2010, a guideline that recommended to screen all patients for Helicobacter pylori was implemented in the Netherlands. H. pylori is an important risk factor in the development of gastric cancer in the general population, and eradication of the bacterium reduces this risk. We aimed to assess the proportion of LS patients being tested and the yield and also addressed the question whether H. pylori infection is more prevalent in LS families with known cases of gastric cancer. METHODS: Proven mutation carriers from five different Dutch hospitals were included. The implementation of H. pylori screening and its outcome was examined. The observation period was 2008-2013. The presence of first-degree family members with gastric cancer was noted, and it was observed if H. pylori infection was more prevalent in Lynch families with known cases of gastric cancer. Obtainable endoscopy reports were reviewed. RESULTS: Four hundred forty-three (male, 184) proven mutation carriers were included. The proportion of patients screened increased after 2010, from 37 to 68%. Twenty percent of the patients were infected. The 25 patients who had a first-degree family member with gastric cancer did not have a higher infection rate. In 30% of cases, an endoscopy was performed; in four patients, intestinal metaplasia and in eight patients, gastric cancer was found. CONCLUSION: The recommendation to screen for H. pylori is increasingly followed. The prevalence of infection in this patient group does not differ from the general population. Patients who had a first-degree family member with gastric cancer did not have a higher infection rate.
BACKGROUND:Patients with Lynch syndrome (LS) are at an increased risk of developing gastric cancer. In 2010, a guideline that recommended to screen all patients for Helicobacter pylori was implemented in the Netherlands. H. pylori is an important risk factor in the development of gastric cancer in the general population, and eradication of the bacterium reduces this risk. We aimed to assess the proportion of LS patients being tested and the yield and also addressed the question whether H. pyloriinfection is more prevalent in LS families with known cases of gastric cancer. METHODS: Proven mutation carriers from five different Dutch hospitals were included. The implementation of H. pylori screening and its outcome was examined. The observation period was 2008-2013. The presence of first-degree family members with gastric cancer was noted, and it was observed if H. pyloriinfection was more prevalent in Lynch families with known cases of gastric cancer. Obtainable endoscopy reports were reviewed. RESULTS: Four hundred forty-three (male, 184) proven mutation carriers were included. The proportion of patients screened increased after 2010, from 37 to 68%. Twenty percent of the patients were infected. The 25 patients who had a first-degree family member with gastric cancer did not have a higher infection rate. In 30% of cases, an endoscopy was performed; in four patients, intestinal metaplasia and in eight patients, gastric cancer was found. CONCLUSION: The recommendation to screen for H. pylori is increasingly followed. The prevalence of infection in this patient group does not differ from the general population. Patients who had a first-degree family member with gastric cancer did not have a higher infection rate.
Authors: Mark van Blankenstein; Anneke J van Vuuren; Caspar W N Looman; Martine Ouwendijk; Ernst J Kuipers Journal: Scand J Gastroenterol Date: 2013-07 Impact factor: 2.423
Authors: Christoph Engel; Markus Loeffler; Verena Steinke; Nils Rahner; Elke Holinski-Feder; Wolfgang Dietmaier; Hans K Schackert; Heike Goergens; Magnus von Knebel Doeberitz; Timm O Goecke; Wolff Schmiegel; Reinhard Buettner; Gabriela Moeslein; Tom G W Letteboer; Encarna Gómez García; Frederik J Hes; Nicoline Hoogerbrugge; Fred H Menko; Theo A M van Os; Rolf H Sijmons; Anja Wagner; Irma Kluijt; Peter Propping; Hans F A Vasen Journal: J Clin Oncol Date: 2012-10-22 Impact factor: 44.544
Authors: Jan J Koornstra; Marian Je Mourits; Rolf H Sijmons; Annemarie M Leliveld; Harry Hollema; Jan H Kleibeuker Journal: Lancet Oncol Date: 2009-04 Impact factor: 41.316
Authors: Patrice Watson; Hans F A Vasen; Jukka-Pekka Mecklin; Inge Bernstein; Markku Aarnio; Heikki J Järvinen; Torben Myrhøj; Lone Sunde; Juul T Wijnen; Henry T Lynch Journal: Int J Cancer Date: 2008-07-15 Impact factor: 7.396
Authors: Shria Kumar; Christina M Dudzik; Mallory Reed; Jessica M Long; Kirk J Wangensteen; Bryson W Katona Journal: Cancer Prev Res (Phila) Date: 2020-08-28