Literature DB >> 26845615

AID hits the jackpot when missing the target.

Amy L Kenter1, Satyendra Kumar2, Robert Wuerffel2, Fernando Grigera2.   

Abstract

Activation induced deaminase is the single B cell specific factor mediating class switch recombination and somatic hypermutation. Numerous studies have shown that AID preferentially targets Ig substrates and also attacks non-Ig substrates to create DNA damage that contributes to lymphomagenesis. AID targeting to Ig loci is linked to transcription but the mechanism governing this process has been obscure. Here we discuss research that illustrates the connection between AID targeting to DNA substrates and transcription processes to reveal rules governing the specificity of AID attack. These observations are woven together to provide a integrated view of AID function and a surprising linkage with global regulation of gene expression.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 26845615      PMCID： PMC4979549          DOI： 10.1016/j.coi.2016.01.008

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  104 in total

1.  Nuclear reprogramming in heterokaryons is rapid, extensive, and bidirectional.

Authors:  Adam Palermo; Regis Doyonnas; Nidhi Bhutani; Jason Pomerantz; Ozan Alkan; Helen M Blau
Journal:  FASEB J       Date:  2009-01-13       Impact factor: 5.191

2.  Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.

Authors:  Cristina Rada; Gareth T Williams; Hilde Nilsen; Deborah E Barnes; Tomas Lindahl; Michael S Neuberger
Journal:  Curr Biol       Date:  2002-10-15       Impact factor: 10.834

3.  Super-enhancers in the control of cell identity and disease.

Authors:  Denes Hnisz; Brian J Abraham; Tong Ihn Lee; Ashley Lau; Violaine Saint-André; Alla A Sigova; Heather A Hoke; Richard A Young
Journal:  Cell       Date:  2013-10-10       Impact factor: 41.582

4.  Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.

Authors:  A Peters; U Storb
Journal:  Immunity       Date:  1996-01       Impact factor: 31.745

5.  Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers.

Authors:  Denes Hnisz; Jurian Schuijers; Charles Y Lin; Abraham S Weintraub; Brian J Abraham; Tong Ihn Lee; James E Bradner; Richard A Young
Journal:  Mol Cell       Date:  2015-03-19       Impact factor: 17.970

Review 6.  Recombination centres and the orchestration of V(D)J recombination.

Authors:  David G Schatz; Yanhong Ji
Journal:  Nat Rev Immunol       Date:  2011-03-11       Impact factor: 53.106

7.  Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming.

Authors:  Hugh D Morgan; Wendy Dean; Heather A Coker; Wolf Reik; Svend K Petersen-Mahrt
Journal:  J Biol Chem       Date:  2004-09-24       Impact factor: 5.157

8.  S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination.

Authors:  Lili Wang; Robert Wuerffel; Scott Feldman; Ahmed Amine Khamlichi; Amy L Kenter
Journal:  J Exp Med       Date:  2009-07-13       Impact factor: 14.307

9.  Two levels of protection for the B cell genome during somatic hypermutation.

Authors:  Man Liu; Jamie L Duke; Daniel J Richter; Carola G Vinuesa; Christopher C Goodnow; Steven H Kleinstein; David G Schatz
Journal:  Nature       Date:  2008-02-14       Impact factor: 49.962

10.  The strength of an Ig switch region is determined by its ability to drive R loop formation and its number of WGCW sites.

Authors:  Zheng Z Zhang; Nicholas R Pannunzio; Li Han; Chih-Lin Hsieh; Kefei Yu; Michael R Lieber
Journal:  Cell Rep       Date:  2014-07-10       Impact factor: 9.423
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  5 in total

1.  Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression.

Authors:  Bart G Jones; Rhiannon R Penkert; Beisi Xu; Yiping Fan; Geoff Neale; Patricia J Gearhart; Julia L Hurwitz
Journal:  Mol Immunol       Date:  2016-08-03       Impact factor: 4.407

2.  BRCT-domain protein BRIT1 influences class switch recombination.

Authors:  Wei-Feng Yen; Ashutosh Chaudhry; Bharat Vaidyanathan; William T Yewdell; Joseph N Pucella; Rahul Sharma; Yulong Liang; Kaiyi Li; Alexander Y Rudensky; Jayanta Chaudhuri
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-19       Impact factor: 11.205

3.  High-throughput immune repertoire analysis with IGoR.

Authors:  Quentin Marcou; Thierry Mora; Aleksandra M Walczak
Journal:  Nat Commun       Date:  2018-02-08       Impact factor: 14.919

4.  AFF3, a susceptibility factor for autoimmune diseases, is a molecular facilitator of immunoglobulin class switch recombination.

Authors:  Shin-Ichi Tsukumo; Poorani Ganesh Subramani; Noé Seija; Mizuho Tabata; Yoichi Maekawa; Yuya Mori; Chieko Ishifune; Yasushi Itoh; Mineto Ota; Keishi Fujio; Javier M Di Noia; Koji Yasutomo
Journal:  Sci Adv       Date:  2022-08-24       Impact factor: 14.957

5.  Reprogramming the antigen specificity of B cells using genome-editing technologies.

Authors:  James E Voss; Alicia Gonzalez-Martin; Raiees Andrabi; Roberta P Fuller; Ben Murrell; Laura E McCoy; Katelyn Porter; Deli Huang; Wenjuan Li; Devin Sok; Khoa Le; Bryan Briney; Morgan Chateau; Geoffrey Rogers; Lars Hangartner; Ann J Feeney; David Nemazee; Paula Cannon; Dennis R Burton
Journal:  Elife       Date:  2019-01-17       Impact factor: 8.140
  5 in total

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