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Literature DB >> 2684300

Immunocytochemical detection of p21ras expression in fresh human leukaemic cells and cell lines.

A Neubauer¹, H Herbst, C Rochlitz, W Siegert, C A Schmidt, D Huhn.

Abstract

The expression of p21ras proteins was investigated by immunocytochemistry in permanent cell lines and in fresh human leukaemic cells. While high and low levels of p21ras could be detected in most of the cell lines, no significant p21ras immunoreactivity was noted in cells of ten human acute and chronic leukaemias. Thus, notwithstanding its possible role in the initial transformation process in human leukaemias, p21ras expression appears not to be an irrevocable requirement for the maintenance of the transformed state.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2684300 DOI： 10.1007/bf00349069

Source DB: PubMed Journal: Blut ISSN： 0006-5242

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References

13 in total

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Authors: J L Cordell; B Falini; W N Erber; A K Ghosh; Z Abdulaziz; S MacDonald; K A Pulford; H Stein; D Y Mason
Journal: J Histochem Cytochem Date: 1984-02 Impact factor: 2.479

Immunocytochemical detection of p21ras expression in fresh human leukaemic cells and cell lines.

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