K Lamvik1,2, E Guiu Hernandez1,2, R Jones1,2,3,4,5, M-L Huckabee1,2. 1. The University of Canterbury Rose Centre for Stroke Recovery and Research, Christchurch, New Zealand. 2. Department of Communication Disorders, University of Canterbury, Christchurch, New Zealand. 3. New Zealand Brain Research Institute, Christchurch, New Zealand. 4. Department of Medical Physics & Bioengineering, Christchurch Hospital, Christchurch, New Zealand. 5. Department of Medicine, University of Otago, Christchurch, New Zealand.
Abstract
BACKGROUND: A substantial pressure drift in high-resolution manometry (HRM) has been reported; however, fundamental questions remain regarding the origin and management of this drift. The aim of this study was to provide critical in-depth analyses of ManoScan(™) HRM drift in vitro and in vivo. METHODS: A total of sixteen 15-min studies and twelve 5-h studies were performed in a water bath at 37 °C at 4.0 cm depth (2.9 mmHg) with ESO and ESO Z catheters. Six 5-h in vitro studies were performed similarly at a depth of 9.0 cm (6.6 mmHg). Eight 15-min studies and nine 8-h in vivo studies were performed with healthy participants. Two correction methods - thermal compensation (TC) and interpolated thermal compensation (ITC) - were tested. KEY RESULTS: Overall pressure drift varied both between studies (p < 0.01) and within sensors (p < 0.01). Drift resulted from thermal shock, an initial pressure change at intubation, and baseline drift, a linear drift over time (R(2) > 0.96). Contrary to previous reports, there was no correlation between drift and average (r = -0.02) or maximum pressure exposure (r = -0.05). Following data correction, ITC had the lowest median error but persisted with a maximum error of 2.5 mmHg (IQR = 3.0). CONCLUSIONS & INFERENCES: The substantial drift in the ManoScan(™) HRM system is highly variable and not corrected via the standard operating instructions. ITC has superior performance but requires communication with the manufacturer to enable this option. This has a substantial impact on clinical diagnosis, utility of existing normative data, and future research of HRM.
BACKGROUND: A substantial pressure drift in high-resolution manometry (HRM) has been reported; however, fundamental questions remain regarding the origin and management of this drift. The aim of this study was to provide critical in-depth analyses of ManoScan(™) HRM drift in vitro and in vivo. METHODS: A total of sixteen 15-min studies and twelve 5-h studies were performed in a water bath at 37 °C at 4.0 cm depth (2.9 mmHg) with ESO and ESO Z catheters. Six 5-h in vitro studies were performed similarly at a depth of 9.0 cm (6.6 mmHg). Eight 15-min studies and nine 8-h in vivo studies were performed with healthy participants. Two correction methods - thermal compensation (TC) and interpolated thermal compensation (ITC) - were tested. KEY RESULTS: Overall pressure drift varied both between studies (p < 0.01) and within sensors (p < 0.01). Drift resulted from thermal shock, an initial pressure change at intubation, and baseline drift, a linear drift over time (R(2) > 0.96). Contrary to previous reports, there was no correlation between drift and average (r = -0.02) or maximum pressure exposure (r = -0.05). Following data correction, ITC had the lowest median error but persisted with a maximum error of 2.5 mmHg (IQR = 3.0). CONCLUSIONS & INFERENCES: The substantial drift in the ManoScan(™) HRM system is highly variable and not corrected via the standard operating instructions. ITC has superior performance but requires communication with the manufacturer to enable this option. This has a substantial impact on clinical diagnosis, utility of existing normative data, and future research of HRM.
Authors: Jesse D Hoffmeister; Christopher L Ulmschneider; Corinne A Jones; Michelle R Ciucci; Timothy M McCulloch Journal: J Speech Lang Hear Res Date: 2021-07-28 Impact factor: 2.297