Franziska Ferk1, Miroslav Mišík1, Armen Nersesyan1, Christoph Pichler1, Walter Jäger2, Thomas Szekeres3, Rodrig Marculescu3, Henrik E Poulsen4, Trine Henriksen4, Roberto Bono5, Valeria Romanazzi5, Halh Al-Serori1, Martin Biendl6, Karl-Heinz Wagner7, Michael Kundi8, Siegfried Knasmüller1. 1. Department of Medicine I, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria. 2. Department for Clinical Pharmacy and Diagnostics, Faculty of Life Sciences, University of Vienna, Vienna, Austria. 3. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria. 4. Laboratory of Clinical Pharmacology Copenhagen, Copenhagen, Denmark. 5. Department of Public Health and Pediatrics, University of Torino, Torino, Italy. 6. Hopsteiner, Hallertauer Hopfenveredelung GmbH, Mainburg, Germany. 7. Department of Nutritional Sciences, University of Vienna, Vienna, Austria. 8. Center for Public Health, Institute of Environmental Health, Medical University of Vienna, Vienna, Austria.
Abstract
SCOPE: Xanthohumol (XN) is a hop flavonoid found in beers and refreshment drinks. Results of in vitro and animal studies indicate that it causes beneficial health effects due to DNA protective, anti-inflammatory, antioxidant, and phytoestrogenic properties. Aim of the present study was to find out if XN causes alterations of health-related parameters in humans. METHODS AND RESULTS: The effects of the flavonoid were investigated in a randomized crossover intervention trial (n = 22) in which the participants consumed a XN drink (12 mg XN/P/day). We monitored alterations of the DNA stability in single cell gel electrophoresis assays in lymphocytes and of several health-related biomarkers. A decrease of oxidatively damaged purines and protection toward reactive oxygen species induced DNA damage was found after the consumption of the beverage; also the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-guanosine in urine was reduced. The assumption that the flavonoid causes DNA protection was confirmed in a randomized follow-up study with pure XN (n = 10) with a parallel design. Other biochemical parameters reflecting the redox- and hormonal status and lipid- and glucose metabolism were not altered after the intervention. CONCLUSION: Taken together, our data indicate that low doses of XN protect humans against oxidative DNA damage.
RCT Entities:
SCOPE: Xanthohumol (XN) is a hop flavonoid found in beers and refreshment drinks. Results of in vitro and animal studies indicate that it causes beneficial health effects due to DNA protective, anti-inflammatory, antioxidant, and phytoestrogenic properties. Aim of the present study was to find out if XN causes alterations of health-related parameters in humans. METHODS AND RESULTS: The effects of the flavonoid were investigated in a randomized crossover intervention trial (n = 22) in which the participants consumed a XN drink (12 mg XN/P/day). We monitored alterations of the DNA stability in single cell gel electrophoresis assays in lymphocytes and of several health-related biomarkers. A decrease of oxidatively damaged purines and protection toward reactive oxygen species induced DNA damage was found after the consumption of the beverage; also the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-guanosine in urine was reduced. The assumption that the flavonoid causes DNA protection was confirmed in a randomized follow-up study with pure XN (n = 10) with a parallel design. Other biochemical parameters reflecting the redox- and hormonal status and lipid- and glucose metabolism were not altered after the intervention. CONCLUSION: Taken together, our data indicate that low doses of XN protect humans against oxidative DNA damage.
Authors: Blake O Langley; Jennifer Joan Ryan; Douglas Hanes; John Phipps; Emily Stack; Thomas O Metz; J Frederik Stevens; Ryan Bradley Journal: Mol Nutr Food Res Date: 2021-03-11 Impact factor: 5.914
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Authors: Bernhard Hennig; Michael C Petriello; Mary V Gamble; Young-Joon Surh; Laura A Kresty; Norbert Frank; Nuchanart Rangkadilok; Mathuros Ruchirawat; William A Suk Journal: Rev Environ Health Date: 2018-03-28 Impact factor: 4.022