Céline Dubron1, Freddy Avni1, Nathalie Boutry1, Dominique Turck2, Alain Duhamel3, Elisa Amzallag-Bellenger1. 1. 1 Department of Pediatric Radiology, Hospital Jeanne de Flandre, CHRU Lille, Lille Cedex, France. 2. 2 Department of Pediatric Gastrology, Hospital Jeanne de Flandre, CHRU Lille, Lille Cedex, France. 3. 3 Department of Statistics, CHRU Lille, Lille Cedex, France.
Abstract
OBJECTIVE: To evaluate prospectively the performance of diffusion-weighted imaging (DWI) for the detection of active lesions on MR enterography (MRE) in children with inflammatory bowel disease (IBD). METHODS: MRE of 48 children (mean age 13 years) with suspected or known IBD were blindly analysed by 2 independent readers for the presence of active lesions. Two sets of imaging including DWI and gadolinium-enhanced imaging (GEI) were reviewed. A reader consensus was obtained. The gold standard was histopathological findings. In patient-level analysis and segment-level analysis, sensitivity and specificity were calculated for DWI and GEI and compared using McNemar's test or logistic random-effects models. RESULTS: At least 1 active lesion was confirmed in 42 (87.5%) children. Sensitivity and specificity for the detection of at least one lesion were 88.1% (95% CI, 74.3-96.1) and 83.3% (95% CI, 35.9-99.6), respectively, for DWI and 66.7% (95% CI, 50.4-80.4) and 83.3% (95% CI, 35.9-99.6), respectively, for GEI. In segment-level analysis, sensitivity and specificity for the detection of specific segment lesions were 62.5% (95% CI, 48.1-75) and 97.1% (95% CI, 93.5-98.7), respectively, for DWI and 45.7% (95% CI, 30.8-61.3) and 98.2% (95% CI, 95.3-99.4), respectively, for GEI. The sensitivity of DWI was significantly better than that of GEI per patient (p = 0.004) and per segment (p = 0.028). CONCLUSION: DWI demonstrates better performance than GEI for the detection of active lesions in children with IBD. ADVANCES IN KNOWLEDGE: Examination with no intravenous injection-DWI can replace T1 weighted images when paediatric patients are screened with MRE for IBD. Examination performed in free breathing is better tolerated by children.
OBJECTIVE: To evaluate prospectively the performance of diffusion-weighted imaging (DWI) for the detection of active lesions on MR enterography (MRE) in children with inflammatory bowel disease (IBD). METHODS: MRE of 48 children (mean age 13 years) with suspected or known IBD were blindly analysed by 2 independent readers for the presence of active lesions. Two sets of imaging including DWI and gadolinium-enhanced imaging (GEI) were reviewed. A reader consensus was obtained. The gold standard was histopathological findings. In patient-level analysis and segment-level analysis, sensitivity and specificity were calculated for DWI and GEI and compared using McNemar's test or logistic random-effects models. RESULTS: At least 1 active lesion was confirmed in 42 (87.5%) children. Sensitivity and specificity for the detection of at least one lesion were 88.1% (95% CI, 74.3-96.1) and 83.3% (95% CI, 35.9-99.6), respectively, for DWI and 66.7% (95% CI, 50.4-80.4) and 83.3% (95% CI, 35.9-99.6), respectively, for GEI. In segment-level analysis, sensitivity and specificity for the detection of specific segment lesions were 62.5% (95% CI, 48.1-75) and 97.1% (95% CI, 93.5-98.7), respectively, for DWI and 45.7% (95% CI, 30.8-61.3) and 98.2% (95% CI, 95.3-99.4), respectively, for GEI. The sensitivity of DWI was significantly better than that of GEI per patient (p = 0.004) and per segment (p = 0.028). CONCLUSION: DWI demonstrates better performance than GEI for the detection of active lesions in children with IBD. ADVANCES IN KNOWLEDGE: Examination with no intravenous injection-DWI can replace T1 weighted images when paediatric patients are screened with MRE for IBD. Examination performed in free breathing is better tolerated by children.
Authors: Andreas G Schreyer; Cynthia Menzel; Chris Friedrich; Florian Poschenrieder; Lukas Egger; Christian Dornia; Gabriela Schill; Lena M Dendl; Doris Schacherer; Christl Girlich; Ernst-Michael Jung Journal: World J Gastroenterol Date: 2011-02-28 Impact factor: 5.742
Authors: Majid Chalian; Arzu Ozturk; Maria Oliva-Hemker; Scott Pryde; Thierry A G M Huisman Journal: AJR Am J Roentgenol Date: 2011-06 Impact factor: 3.959
Authors: Melvin B Heyman; Barbara S Kirschner; Benjamin D Gold; George Ferry; Robert Baldassano; Stanley A Cohen; Harland S Winter; Patricia Fain; Chris King; Terry Smith; Hashem B El-Serag Journal: J Pediatr Date: 2005-01 Impact factor: 4.406
Authors: Athos Bousvaros; Donald A Antonioli; Richard B Colletti; Marla C Dubinsky; Jonathan N Glickman; Benjamin D Gold; Anne M Griffiths; Gareth P Jevon; Leslie M Higuchi; Jeffrey S Hyams; Barbara S Kirschner; Subra Kugathasan; Robert N Baldassano; Pierre A Russo Journal: J Pediatr Gastroenterol Nutr Date: 2007-05 Impact factor: 2.839
Authors: Katarzyna B Biernacka; Dobromiła Barańska; Katarzyna Matera; Michał Podgórski; Elżbieta Czkwianianc; Katarzyna Szabelska-Zakrzewska; Inga Dziembowska; Piotr Grzelak Journal: Pol J Radiol Date: 2021-03-03