STUDY OBJECTIVE: The purpose of this study was to evaluate the association of first-trimester serum lipid profile with preeclampsia (PE) and if so, its association with the severity of the disease. STUDY: Prospective cohort study. PATIENT AND METHODS: A total of 251 pregnant women participated in this study in their first trimester. Maternal blood samples were collected between 4 and 12 weeks of gestation. Fasting serum triglycerides (TGs), total cholesterol (TC), HDL-cholesterol, and low-density lipoprotein cholesterol (LDL-C) were drawn and measured by ELISA. From the cohort, 26 women developed PE (16 mild and 10 severe) and 174 remained normotensive and used as control subjects. RESULTS: There was a significant rise in fasting serum TGs, TC, and LDL-C and a significant decrease in HDL-C in women who developed PE than in those who remained normotensive and more significantly evident in severe preeclamptic cases compared to mild cases of PE (p < 0.05). CONCLUSION: Early pregnancy dyslipidemia, particularly hypertriglyceridemia and hypercholesterolemia, may help in predicting women who later develop PE and may help in prediction of its severity.
STUDY OBJECTIVE: The purpose of this study was to evaluate the association of first-trimester serum lipid profile with preeclampsia (PE) and if so, its association with the severity of the disease. STUDY: Prospective cohort study. PATIENT AND METHODS: A total of 251 pregnant women participated in this study in their first trimester. Maternal blood samples were collected between 4 and 12 weeks of gestation. Fasting serum triglycerides (TGs), total cholesterol (TC), HDL-cholesterol, and low-density lipoprotein cholesterol (LDL-C) were drawn and measured by ELISA. From the cohort, 26 women developed PE (16 mild and 10 severe) and 174 remained normotensive and used as control subjects. RESULTS: There was a significant rise in fasting serum TGs, TC, and LDL-C and a significant decrease in HDL-C in women who developed PE than in those who remained normotensive and more significantly evident in severe preeclamptic cases compared to mild cases of PE (p < 0.05). CONCLUSION: Early pregnancy dyslipidemia, particularly hypertriglyceridemia and hypercholesterolemia, may help in predicting women who later develop PE and may help in prediction of its severity.
Authors: K M Renault; E M Carlsen; S Hædersdal; L Nilas; N J Secher; J Eugen-Olsen; D Cortes; S F Olsen; T I Halldorsson; K Nørgaard Journal: Int J Obes (Lond) Date: 2017-01-17 Impact factor: 5.095
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Authors: G S Stødle; G B Silva; L H Tangerås; L M Gierman; I Nervik; U E Dahlberg; C Sun; M H Aune; L C V Thomsen; L Bjørge; A-C Iversen Journal: Clin Exp Immunol Date: 2018-04-23 Impact factor: 4.330
Authors: I C Rodrigues; C Grandi; V M F Simões; R F L Batista; L S Rodrigues; V C Cardoso Journal: Braz J Med Biol Res Date: 2020-12-07 Impact factor: 2.590
Authors: Janet M Catov; Rebecca B McNeil; Derek J Marsh; Brian M Mercer; C Noel Bairey Merz; Corette B Parker; Victoria L Pemberton; George R Saade; Yii-Der Ida Chen; Judith H Chung; Deborah B Ehrenthal; William A Grobman; David M Haas; Samuel Parry; LuAnn Polito; Uma M Reddy; Robert M Silver; Hyagriv N Simhan; Ronald J Wapner; Michelle Kominiarek; Rolf Kreutz; Lisa D Levine; Philip Greenland Journal: J Am Heart Assoc Date: 2021-02-23 Impact factor: 6.106