Literature DB >> 26828286

Adsorption of the cis-[Pt(NH3)2(P2O7)](2-) (phosphaplatin) on hydroxyapatite nanocrystals as a smart way to selectively release activated cis-[Pt(NH3)2Cl2] (cisplatin) in tumor tissues.

Michele Benedetti1, Federica De Castro2, Alessandro Romano3, Danilo Migoni2, Barbara Piccinni2, Tiziano Verri2, Marco Lelli4, Norberto Roveri4, Francesco P Fanizzi5.   

Abstract

The relevant adsorption of cis-[Pt(NH3)2(P2O7)](2-) (phosphaplatin) on hydroxyapatite nanocrystals (nHAP) was observed and studied in water suspension. Phosphaplatin cytotoxicity, which is very low for HeLa, MCF-7 and HS-5 cell lines could be enhanced, reaching that of cisplatin, by interaction with solid nHAP. This effect stems from nHAP ability to catalyze the phosphaplatin hydrolysis, producing the same hydrolytic species responsible for cisplatin antitumor activity.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Antitumor drug; Hydroxyapatite; Nanoparticles; Platinum drug; cisplatin; phosphaplatin

Mesh：

Substances：

Year:  2016        PMID： 26828286     DOI： 10.1016/j.jinorgbio.2016.01.019

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  5 in total

1.  A NMR-Based Metabolomic Approach to Investigate the Antitumor Effects of the Novel [Pt(η 1-C2H4OMe)(DMSO)(phen)]+ (phen = 1,10-Phenanthroline) Compound on Neuroblastoma Cancer Cells.

Authors:  Federica De Castro; Erika Stefàno; Erik De Luca; Antonella Muscella; Santo Marsigliante; Michele Benedetti; Francesco Paolo Fanizzi
Journal:  Bioinorg Chem Appl       Date:  2022-06-10       Impact factor: 4.724

2.  Synthesis and Evaluation of the Cytotoxic Activity of Water-Soluble Cationic Organometallic Complexes of the Type [Pt(η1-C2H4OMe)(L)(Phen)]+ (L = NH3, DMSO; Phen = 1,10-Phenanthroline).

Authors:  Federica De Castro; Erika Stefàno; Danilo Migoni; Giorgia N Iaconisi; Antonella Muscella; Santo Marsigliante; Michele Benedetti; Francesco P Fanizzi
Journal:  Pharmaceutics       Date:  2021-04-30       Impact factor: 6.321

3.  Biomimetic hydroxyapatite nanocrystals are an active carrier for Salmonella bacteriophages.

Authors:  Andrea Fulgione; Flora Ianniello; Marina Papaianni; Felice Contaldi; Tiziana Sgamma; Cinzia Giannini; Stella Pastore; Raffaele Velotta; Bartolomeo Della Ventura; Norberto Roveri; Marco Lelli; Federico Capuano; Rosanna Capparelli
Journal:  Int J Nanomedicine       Date:  2019-03-28

4.  Crystallization of carboplatin-loaded onto microporous calcium phosphate using high-vacuum method: Characterization and release study.

Authors:  Cristiane Savicki; Nelson Heriberto Almeida Camargo; Enori Gemelli
Journal:  PLoS One       Date:  2020-12-08       Impact factor: 3.240

Review 5.  Hydroxyapatite Biobased Materials for Treatment and Diagnosis of Cancer.

Authors:  María Del Carmen De Lama-Odría; Luis J Del Valle; Jordi Puiggalí
Journal:  Int J Mol Sci       Date:  2022-09-26       Impact factor: 6.208
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.