Kristin L McBain1, Eric T Payne, Rohit Sharma, Helena Frndova, Nicholas S Abend, Sarah M Sánchez, William B Gallentine, Karen M Cornett, Kendall B Nash, O Carter Snead, Christopher S Parshuram, Jamie S Hutchison, Cecil D Hahn. 1. 1Division of Neurology, Department of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada. 2Department of Critical Care Medicine, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada. 3Division of Pediatric Neurology, Department of Neurology, Mayo Clinic, Rochester, MN. 4Departments of Neurology and Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. 5Division of Neurology, Department of Pediatrics, Duke Children's Hospital and Duke University School of Medicine, Durham, NC. 6Department of Neurology, University of California San Francisco, San Francisco, CA.
Abstract
OBJECTIVES: To analyze barriers to recruitment encountered during a prospective study in the PICU and evaluate strategies implemented to improve recruitment. DESIGN: Prospective observational study of continuous electroencephalogram monitoring in comatose children. SETTING: PICUs at four North American institutions. PATIENTS: Patients with a Glasgow Coma Scale score of less than or equal to 8 for at least an hour. INTERVENTIONS: Four strategies to increase recruitment were sequentially implemented. MEASUREMENTS AND MAIN RESULTS: The baseline enrollment rate was 2.1 subjects/mo, which increased following the single-site introduction of real-time patient screening using an online dashboard (4.5 subjects/mo), deferred consenting (5.2 subjects/mo), and weekend screening (6.1 subjects/mo). However, the subsequent addition of three new study sites was the greatest accelerator of enrollment (21 subjects/mo), representing a 10-fold increase from baseline (p < 0.0001). CONCLUSIONS: Identifying barriers to recruitment and implementing creative strategies to increase recruitment can successfully increase enrollment rates in the challenging ICU environment.
OBJECTIVES: To analyze barriers to recruitment encountered during a prospective study in the PICU and evaluate strategies implemented to improve recruitment. DESIGN: Prospective observational study of continuous electroencephalogram monitoring in comatosechildren. SETTING: PICUs at four North American institutions. PATIENTS: Patients with a Glasgow Coma Scale score of less than or equal to 8 for at least an hour. INTERVENTIONS: Four strategies to increase recruitment were sequentially implemented. MEASUREMENTS AND MAIN RESULTS: The baseline enrollment rate was 2.1 subjects/mo, which increased following the single-site introduction of real-time patient screening using an online dashboard (4.5 subjects/mo), deferred consenting (5.2 subjects/mo), and weekend screening (6.1 subjects/mo). However, the subsequent addition of three new study sites was the greatest accelerator of enrollment (21 subjects/mo), representing a 10-fold increase from baseline (p < 0.0001). CONCLUSIONS: Identifying barriers to recruitment and implementing creative strategies to increase recruitment can successfully increase enrollment rates in the challenging ICU environment.
Authors: Mary E Larkin; Catherine C Beauharnais; Kendra Magyar; Laurel Macey; Kerry B Grennan; Emily E Boykin; Steven J Russell Journal: Clin Trials Date: 2012-11-20 Impact factor: 2.486
Authors: Jessie M Hulst; Jeroen W B Peters; Ada van den Bos; Koen F M Joosten; Johannes B van Goudoever; Luc J I Zimmermann; Dick Tibboel Journal: Intensive Care Med Date: 2005-05-13 Impact factor: 17.440