AIMS: The purpose of this study was to explore the role of TNF-like ligand 1A (TL1A) gene (TNFST15) polymorphisms (rs3810936, rs7848647, and rs6478109) in the generation of ankylosing spondylitis (AS). METHODS: Polymerase chain reaction (PCR) and sequencing were used to conduct the genotyping of TNFSF15 polymorphisms in 113 AS patients and 120 healthy persons as the case and control groups. The frequencies comparison was performed by chi-square or t test between the two groups. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated to represent the correlation between TNFSF15 polymorphism and AS. Besides, genotypes distribution of the former in controls was checked by Hardy-Weinberg equilibrium (HWE). RESULTS: There was statistically significant difference in AS patients and controls based on family history. Among TNFSF15 polymorphisms, only TT genotype frequency of rs3810936 in cases was obviously high, compared with the controls (P=0.04), the results indicated that TT was a high-risk genotype (OR=2.31, 95% CI=1.03-5.20). However, both of rs6478109, rs7848647 polymorphisms didn't show any association with AS. CONCLUSION: Rs3810936 of TNFSF15 were related to the risk of AS and we should pay more attention to the role of TNFSF15 polymorphisms in the pathogenesis of AS in the future.
AIMS: The purpose of this study was to explore the role of TNF-like ligand 1A (TL1A) gene (TNFST15) polymorphisms (rs3810936, rs7848647, and rs6478109) in the generation of ankylosing spondylitis (AS). METHODS: Polymerase chain reaction (PCR) and sequencing were used to conduct the genotyping of TNFSF15 polymorphisms in 113 AS patients and 120 healthy persons as the case and control groups. The frequencies comparison was performed by chi-square or t test between the two groups. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated to represent the correlation between TNFSF15 polymorphism and AS. Besides, genotypes distribution of the former in controls was checked by Hardy-Weinberg equilibrium (HWE). RESULTS: There was statistically significant difference in AS patients and controls based on family history. Among TNFSF15 polymorphisms, only TT genotype frequency of rs3810936 in cases was obviously high, compared with the controls (P=0.04), the results indicated that TT was a high-risk genotype (OR=2.31, 95% CI=1.03-5.20). However, both of rs6478109, rs7848647 polymorphisms didn't show any association with AS. CONCLUSION:Rs3810936 of TNFSF15 were related to the risk of AS and we should pay more attention to the role of TNFSF15 polymorphisms in the pathogenesis of AS in the future.
Authors: Thi Sau Migone; Jun Zhang; Xia Luo; Li Zhuang; Cecil Chen; Bugen Hu; June S Hong; James W Perry; Su Fang Chen; Joe X H Zhou; Yun Hee Cho; Stephen Ullrich; Palanisamy Kanakaraj; Jeffrey Carrell; Ernest Boyd; Henrik S Olsen; Gang Hu; Laurie Pukac; Ding Liu; Jian Ni; Sunghee Kim; Reiner Gentz; Ping Feng; Paul A Moore; Steve M Ruben; Ping Wei Journal: Immunity Date: 2002-03 Impact factor: 31.745
Authors: A Wanders; R Landewé; A Spoorenberg; K de Vlam; H Mielants; M Dougados; S van der Linden; D van der Heijde Journal: Ann Rheum Dis Date: 2004-08-05 Impact factor: 19.103
Authors: Marco A Rocha Loures; Luciana C Macedo; Denise M Reis; Camila F Oliveira; Jean L Meneguetti; Gabriela F Martines; Janisleya S F Neves; Eliana de Souza; Ana M Sell; Jeane E L Visentainer Journal: Mediators Inflamm Date: 2018-04-19 Impact factor: 4.711
Authors: Yun-Jeong Song; In Ah Choi; Françoise Meylan; M Kristen Demoruelle; Taylor Farley; Arianne C Richard; Eric Hawley; John Botson; Yoo Jin Hong; Eun Young Lee; Sabina R Mian; Bartlett C Hamilton; Geoffrey M Thiele; Ted R Mikuls; Naveen Gara; Chris D Ward; Sarah Lamberth; Kevin D Deane; Theo Heller; Michael M Ward; David M Lee; Thi-Sau Migone; William Stohl; James R O'Dell; Jill M Norris; V Michael Holers; Peter Gregersen; Yeong-Wook Song; Richard M Siegel Journal: Arthritis Res Ther Date: 2020-05-07 Impact factor: 5.156