Richard J Holleyman1,2, Paul N Baker1,3, Andre Charlett4, Kate Gould5, David J Deehan1,6. 1. Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne - UK. 2. Health Education North East, Newcastle upon Tyne - UK. 3. Department of Trauma and Orthopaedics, James Cook University Hospital, Middlesbrough - UK. 4. Centre for Infectious Disease Surveillance and Control, Public Health England, London - UK. 5. Newcastle Public Health Laboratory, Public Health England, Freeman Hospital, Newcastle upon Tyne - UK. 6. Department of Trauma and Orthopaedics, Freeman Hospital, Newcastle upon Tyne - UK.
Abstract
INTRODUCTION: This study aimed to describe the epidemiology of the causative organism in a series of primary hip arthroplasties revised for a diagnosis of periprosthetic joint infection (PJI) in England and Wales. METHODS: Patient data from the National Joint Registry (NJR) was linked to microbiology data held by Public Health England (PHE) which identified a series of 248 primary hip arthroplasties revised for PJI between 2003 and 2014. Definitive cultures, isolated at time of revision surgery, were available for all cases. Total hip arthroplasty (n = 239, 96%) and hip resurfacing (n = 5, 2%) were the most commonly performed primary procedures. A two-stage revision was the most common operative management (n = 174, 70%). RESULTS: 202 (81%) cases were infected with a single genus microorganism and the most commonly implicated genus was Staphylococcus species (70% of all single genus infections). Staphylococcus species were also the most commonly identified microorganism in mixed genus infections (74% of patient's cultures). There was a significant difference in microorganism distribution when comparing uncemented vs cement implant fixation, with a higher incidence of Gram-negative infection observed in the uncemented group (p = 0.048, Chi-square). CONCLUSIONS: Both prophylactic and therapeutic antibiotic regimes should be focused on targeting Staphylococci.
INTRODUCTION: This study aimed to describe the epidemiology of the causative organism in a series of primary hip arthroplasties revised for a diagnosis of periprosthetic joint infection (PJI) in England and Wales. METHODS:Patient data from the National Joint Registry (NJR) was linked to microbiology data held by Public Health England (PHE) which identified a series of 248 primary hip arthroplasties revised for PJI between 2003 and 2014. Definitive cultures, isolated at time of revision surgery, were available for all cases. Total hip arthroplasty (n = 239, 96%) and hip resurfacing (n = 5, 2%) were the most commonly performed primary procedures. A two-stage revision was the most common operative management (n = 174, 70%). RESULTS: 202 (81%) cases were infected with a single genus microorganism and the most commonly implicated genus was Staphylococcus species (70% of all single genus infections). Staphylococcus species were also the most commonly identified microorganism in mixed genus infections (74% of patient's cultures). There was a significant difference in microorganism distribution when comparing uncemented vs cement implant fixation, with a higher incidence of Gram-negative infection observed in the uncemented group (p = 0.048, Chi-square). CONCLUSIONS: Both prophylactic and therapeutic antibiotic regimes should be focused on targeting Staphylococci.
Authors: Erik Lenguerrand; Michael R Whitehouse; Andrew D Beswick; Setor K Kunutsor; Ben Burston; Martyn Porter; Ashley W Blom Journal: Lancet Infect Dis Date: 2018-07-25 Impact factor: 25.071