Ashley Truong1, M Mercedes Sayago2, William H Kutteh3, Raymond W Ke4. 1. Department of Biochemistry and Molecular Biology, Rhodes College, Memphis, Tennessee. 2. Newport Beach Women's Wellness Center, Newport Beach, California. 3. Department of Obstetrics and Gynecology, Fertility Associates of Memphis, Vanderbilt University, Memphis, Tennessee. Electronic address: wkutteh@fertilitymemphis.com. 4. Department of Obstetrics and Gynecology, Fertility Associates of Memphis, Vanderbilt University, Memphis, Tennessee.
Abstract
OBJECTIVE: To determine the frequency of subchorionic hematomas (SCH) in first-trimester ultrasound examinations of patients with infertility and recurrent pregnancy loss (RPL) and in patients from a general obstetric population. To determine if the method of assisted reproduction utilized or the use of anticoagulants, such as heparin and aspirin (ASA), influenced frequency of SCH. DESIGN: Prospective, cohort study. SETTING: Fertility clinic and general obstetrics clinic. PATIENT(S): Five hundred and thirty-three women who were pregnant in the first-trimester. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE(S): Frequencies of subchorionic hematomas in women based on diagnosis, use of anticoagulants, and fertility treatment. RESULT(S): SCH were identified in 129/321 (40.2%) in the study group compared to 23/212 (10.9%) in the control group. Fertility diagnosis and the use of heparin did not appear to affect the frequency of SCH in the first trimester; however, SCH occurred at an almost four-fold increase in patients taking ASA compared to those not taking ASA, regardless of fertility diagnosis or method of fertility treatment. CONCLUSION(S): The use of ASA may be associated with an increased risk of developing a SCH during the first trimester. The increased frequencies of SCH in pregnancies of patients attending a fertility clinic compared to women from a general obstetrical practice was highly correlated with the use of ASA.
OBJECTIVE: To determine the frequency of subchorionic hematomas (SCH) in first-trimester ultrasound examinations of patients with infertility and recurrent pregnancy loss (RPL) and in patients from a general obstetric population. To determine if the method of assisted reproduction utilized or the use of anticoagulants, such as heparin and aspirin (ASA), influenced frequency of SCH. DESIGN: Prospective, cohort study. SETTING: Fertility clinic and general obstetrics clinic. PATIENT(S): Five hundred and thirty-three women who were pregnant in the first-trimester. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE(S): Frequencies of subchorionic hematomas in women based on diagnosis, use of anticoagulants, and fertility treatment. RESULT(S): SCH were identified in 129/321 (40.2%) in the study group compared to 23/212 (10.9%) in the control group. Fertility diagnosis and the use of heparin did not appear to affect the frequency of SCH in the first trimester; however, SCH occurred at an almost four-fold increase in patients taking ASA compared to those not taking ASA, regardless of fertility diagnosis or method of fertility treatment. CONCLUSION(S): The use of ASA may be associated with an increased risk of developing a SCH during the first trimester. The increased frequencies of SCH in pregnancies of patients attending a fertility clinic compared to women from a general obstetrical practice was highly correlated with the use of ASA.
Authors: Matthew T Connell; Lindsey A Sjaarda; Rose G Radin; Daniel Kuhr; Sunni L Mumford; Torie C Plowden; Robert M Silver; Enrique F Schisterman Journal: Semin Reprod Med Date: 2017-10-16 Impact factor: 1.303
Authors: Brady T West; Parviz K Kavoussi; Kate C Odenwald; Krista London; Caitlin L Hunn; Shu-Hung Chen; John David Wininger; Melissa S Gilkey; Keikhosrow M Kavoussi; Shahryar K Kavoussi Journal: J Assist Reprod Genet Date: 2020-01-06 Impact factor: 3.412