Tatsuro Yamaguchi1, Hideyuki Ishida2, Hideki Ueno3, Hirotoshi Kobayashi4, Takao Hinoi5, Yasuhiro Inoue6, Fumio Ishida7, Yukihide Kanemitsu8, Tsuyoshi Konishi9, Naohiro Tomita10, Nagahide Matsubara10, Toshiaki Watanabe11, Kenichi Sugihara12. 1. Department of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum tatsuro@yamaguchi.email.ne.jp. 2. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama. 3. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Surgery, National Defense Medical College, Saitama. 4. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, Tokyo. 5. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima. 6. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie. 7. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama. 8. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Colorectal Surgery Division, National Cancer Center Hospital, Tokyo. 9. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Gastroenterological Surgery, Gastroenterological Center, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo. 10. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Surgery, Hyogo College of Medicine, Hyogo. 11. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo. 12. Study Group for Familial Adenomatous Polyposis (FAP) in the Japanese Society for Cancer of the Colon and Rectum Tokyo Medical and Dental University, Tokyo, Japan.
Abstract
OBJECTIVE: The upper gastrointestinal characteristics in Japanese familial adenomatous polyposis patients have not yet been clarified. The aim of the present study was to elucidate these characteristics in Japanese familial adenomatous polyposis patients. METHODS: This study was conducted by the study group for familial adenomatous polyposis in the Japanese Society for Cancer of the Colon and Rectum. Familial adenomatous polyposis patients who underwent surgical resection from 2000 to 2012 were included in the study. RESULTS: In total, 303 familial adenomatous polyposis patients were enrolled, with 265 cases of classical familial adenomatous polyposis (≥100 adenomas) and 38 cases of attenuated familial adenomatous polyposis (<100 adenomas). Fundic gland polyps were significantly more common in classical familial adenomatous polyposis than in attenuated familial adenomatous polyposis; however, gastric cancer was significantly less common in classical familial adenomatous polyposis than in attenuated familial adenomatous polyposis. Gastric cancer and duodenal adenoma were significantly more common in familial adenomatous polyposis patients with gastric adenoma than in those without gastric adenoma. Duodenal cancer was detected in 7 of 72 familial adenomatous polyposis patients with duodenal adenoma. The median tumour risk in 50-year-old familial adenomatous polyposis patients was 55.3, 21.8, 3.8, 39.2 and 7.7% for fundic gland polyp, gastric adenoma, gastric cancer, duodenal adenoma and duodenal cancer, respectively. CONCLUSIONS: Upper gastrointestinal tumours/polyps were frequently found in familial adenomatous polyposis patients, and their incidences were correlated; however, the frequency of gastric cancer in Japanese familial adenomatous polyposis patients was similar to that in the general population.
OBJECTIVE: The upper gastrointestinal characteristics in Japanese familial adenomatous polyposispatients have not yet been clarified. The aim of the present study was to elucidate these characteristics in Japanese familial adenomatous polyposispatients. METHODS: This study was conducted by the study group for familial adenomatous polyposis in the Japanese Society for Cancer of the Colon and Rectum. Familial adenomatous polyposispatients who underwent surgical resection from 2000 to 2012 were included in the study. RESULTS: In total, 303 familial adenomatous polyposispatients were enrolled, with 265 cases of classical familial adenomatous polyposis (≥100 adenomas) and 38 cases of attenuated familial adenomatous polyposis (<100 adenomas). Fundic gland polyps were significantly more common in classical familial adenomatous polyposis than in attenuated familial adenomatous polyposis; however, gastric cancer was significantly less common in classical familial adenomatous polyposis than in attenuated familial adenomatous polyposis. Gastric cancer and duodenal adenoma were significantly more common in familial adenomatous polyposispatients with gastric adenoma than in those without gastric adenoma. Duodenal cancer was detected in 7 of 72 familial adenomatous polyposispatients with duodenal adenoma. The median tumour risk in 50-year-old familial adenomatous polyposispatients was 55.3, 21.8, 3.8, 39.2 and 7.7% for fundic gland polyp, gastric adenoma, gastric cancer, duodenal adenoma and duodenal cancer, respectively. CONCLUSIONS:Upper gastrointestinal tumours/polyps were frequently found in familial adenomatous polyposispatients, and their incidences were correlated; however, the frequency of gastric cancer in Japanese familial adenomatous polyposispatients was similar to that in the general population.
Authors: N Watanabe; H Seno; T Nakajima; S Yazumi; S Miyamoto; S Matsumoto; T Itoh; C Kawanami; K Okazaki; T Chiba Journal: Gut Date: 2002-11 Impact factor: 23.059
Authors: J Groden; A Thliveris; W Samowitz; M Carlson; L Gelbert; H Albertsen; G Joslyn; J Stevens; L Spirio; M Robertson Journal: Cell Date: 1991-08-09 Impact factor: 41.582
Authors: Fábio Guilherme Campos; Carlos Augusto Real Martinez; Leonardo Alfonso Bustamante Lopez; Danilo Toshio Kanno; Sérgio Carlos Nahas; Ivan Cecconello Journal: J Gastrointest Oncol Date: 2017-10