Gankyrin regulates cell signaling network.

Gankyrin is an oncoprotein that facilitates the degradation of two key tumor suppressors, namely, Rb and p53. Although Gankyrin overexpression was identified in different carcinomas eventually and associated with poor prognosis, its function and mechanism remain not well understood. Recently, the signal transduction mechanisms of Gankyrin have been explored, which may provide new drug targets in tumors overexpressing Gankyrin. In this review, we summarize the significant signal transduction pathways regulated by Gankyrin.