Ismail Labgaa1, Gaëtan-Romain Joliat1, Nicolas Demartines2, Martin Hübner1. 1. Department of Visceral Surgery, University Hospital of Lausanne (CHUV), Switzerland. 2. Department of Visceral Surgery, University Hospital of Lausanne (CHUV), Switzerland. Electronic address: demartines@chuv.ch.
Abstract
BACKGROUND: The morbidity associated with liver surgery remained substantially high despite considerable surgical and anesthetic improvements. The unmet need of accurate biomarkers to predict postoperative complications is widely accepted. AIMS: This pilot study aimed to assess serum albumin as a surrogate marker of surgical stress and to test its potential predictive role for postoperative complications. METHODS: This retrospective pilot study included 106 patients who underwent liver surgery between 2010 and 2014. Serum albumin levels were measured pre- and post-operatively. Maximal albumin decrease (AlbΔmin) was correlated with complications. RESULTS: Serum albumin rapidly dropped after surgery. AlbΔmin was significantly increased in patients with complications (14.5±6.0g/L vs. 10.3±7.2, p=0.009). On multivariate analysis, ASA III/IV (p=0.016) and AlbΔmin (p=0.037) were the only predictors of overall complications. CONCLUSION: Early postoperative drop of serum albumin reflects the intensity of the surgical stress and may predict complications after liver surgery. Serum albumin is a biomarker displaying precious features and deserving further prospective investigations.
BACKGROUND: The morbidity associated with liver surgery remained substantially high despite considerable surgical and anesthetic improvements. The unmet need of accurate biomarkers to predict postoperative complications is widely accepted. AIMS: This pilot study aimed to assess serum albumin as a surrogate marker of surgical stress and to test its potential predictive role for postoperative complications. METHODS: This retrospective pilot study included 106 patients who underwent liver surgery between 2010 and 2014. Serum albumin levels were measured pre- and post-operatively. Maximal albumin decrease (AlbΔmin) was correlated with complications. RESULTS:Serum albumin rapidly dropped after surgery. AlbΔmin was significantly increased in patients with complications (14.5±6.0g/L vs. 10.3±7.2, p=0.009). On multivariate analysis, ASA III/IV (p=0.016) and AlbΔmin (p=0.037) were the only predictors of overall complications. CONCLUSION: Early postoperative drop of serum albumin reflects the intensity of the surgical stress and may predict complications after liver surgery. Serum albumin is a biomarker displaying precious features and deserving further prospective investigations.
Authors: Gaëtan-Romain Joliat; Arnaud Schoor; Markus Schäfer; Nicolas Demartines; Martin Hübner; Ismail Labgaa Journal: Perioper Med (Lond) Date: 2022-02-15
Authors: Mateusz Wierdak; Magdalena Pisarska; Beata Kuśnierz-Cabala; Jan Witowski; Jadwiga Dworak; Piotr Major; Piotr Małczak; Piotr Ceranowicz; Andrzej Budzyński; Michał Pędziwiatr Journal: Surg Endosc Date: 2018-01-16 Impact factor: 4.584