D Kljucevsek1, L Kompan2. 1. University Medical Centre Ljubljana, Zaloška cesta 7, 1000, Ljubljana, Slovenia. 2. Institute of Oncology, Zaloška cesta 2, 1000, Ljubljana, Slovenia. lidija.kompan@mf.uni-lj.si.
Abstract
PURPOSE: Relevant information on the adequacy of intestinal perfusion is needed. The objective of our study was to investigate the relationship between the difference in intra-mucosal and arterial CO2 pressure (pCO2 gap) and the outcome in multiply injured patients and relations between the pCO2 gap and intestinal permeability (IP). METHODS: Forty consecutive multiply injured patients, admitted to the intensive care unit (ICU) of the University Medical Centre Ljubljana, were studied prospectively. On days 2 and 4, IP was measured using the lactulose-mannitol (L/M) test. For 4 days, the pCO2 gap was measured using air tonometry. Multiple organ failure (MOF) scores were calculated daily. RESULTS: No significant differences in the MOF scores and length of ICU stay were found between the groups formed with respect to the presumably normal pCO2 gap value of 1.33 kPa. The baseline pCO2 gap difference in patients with abdominal injuries was significantly (p = 0.01) higher in comparison with those without abdominal injuries. There was no correlation between the pCO2 gap values and L/M index measured simultaneously and also between the baseline and average pCO2 gap and L/M index measured on days 2 and 4. We were unable to find any association between the MOF score and pCO2 gap. The MOF score, however, correlated significantly with the L/M value determined on day 4 (r = 0.85, p = 0.02). The average gastric retention volume was inversely correlated with the average pCO2 gap (r = -0.33, p = 0.04). CONCLUSIONS: The pCO2 gap in trauma patients on intra-gastric enteral nutrition in the phase of present technical solutions has no prognostic value for the development of MOF, but IP correlated with it.
PURPOSE: Relevant information on the adequacy of intestinal perfusion is needed. The objective of our study was to investigate the relationship between the difference in intra-mucosal and arterial CO2 pressure (pCO2 gap) and the outcome in multiply injured patients and relations between the pCO2 gap and intestinal permeability (IP). METHODS: Forty consecutive multiply injured patients, admitted to the intensive care unit (ICU) of the University Medical Centre Ljubljana, were studied prospectively. On days 2 and 4, IP was measured using the lactulose-mannitol (L/M) test. For 4 days, the pCO2 gap was measured using air tonometry. Multiple organ failure (MOF) scores were calculated daily. RESULTS: No significant differences in the MOF scores and length of ICU stay were found between the groups formed with respect to the presumably normal pCO2 gap value of 1.33 kPa. The baseline pCO2 gap difference in patients with abdominal injuries was significantly (p = 0.01) higher in comparison with those without abdominal injuries. There was no correlation between the pCO2 gap values and L/M index measured simultaneously and also between the baseline and average pCO2 gap and L/M index measured on days 2 and 4. We were unable to find any association between the MOF score and pCO2 gap. The MOF score, however, correlated significantly with the L/M value determined on day 4 (r = 0.85, p = 0.02). The average gastric retention volume was inversely correlated with the average pCO2 gap (r = -0.33, p = 0.04). CONCLUSIONS: The pCO2 gap in traumapatients on intra-gastric enteral nutrition in the phase of present technical solutions has no prognostic value for the development of MOF, but IP correlated with it.