Literature DB >> 26814666

PET-CT with MR Fusion: Single Comprehensive Preoperative Metastatic Workup in Head and Neck Malignancy: A Case Report.

Karan Gupta1, Dushyant Mandlik2, Purvi Patel2, Tushar Desai3, Kaustubh D Patel4.   

Abstract

Head neck cancers (HNC) are the sixth most common cancer worldwide. In presence of the complex anatomy of this region, early diagnosis can sometimes be a challenge. At present for the TNM staging, contrast enhanced CT and MRI are the primary imaging modalities for evaluating T stage of HNSCC. Multiple studies suggest that PET/CT might be superior to conventional imaging (CT or MRI) in initial staging and may alter management and treatment especially when distant metastases are discovered. We present a case of a 35-year-old patient who presented to us with an ulcerative lesion on the left buccal mucosa, which was staged as cT2N0M0, using the conventional radiology. But on subsequent imaging by PET-CT with MR-fusion was upstaged to cT4bN0M0, thus completely changing the management of the patient. With the recent advances in technology leading to fusion of MRI images with PET-CT images have combined the benefits of all three imaging modalities and has led to increased sensitivity towards soft tissue and peri-neural invasion of tumours leading to upstaging of primary oral cavity malignancies, altering their management. Accuracy is increased when the information of multiple imaging modalities are analysed together and has the potential of changing the management plan of patients.

Entities:  

Keywords:  Perineural invasion; Prognosis; TNM staging

Year:  2015        PMID: 26814666      PMCID: PMC4717769          DOI: 10.7860/JCDR/2015/14561.6876

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  15 in total

Review 1.  Accuracy of whole-body PET and PET-CT in initial M staging of head and neck cancer: a meta-analysis.

Authors:  Guo-Zeng Xu; Xiao-Dong Zhu; Ming-Yao Li
Journal:  Head Neck       Date:  2011-01       Impact factor: 3.147

2.  The role of positron emission tomography and computed tomography fusion in the management of early-stage and advanced-stage primary head and neck squamous cell carcinoma.

Authors:  Patrick K Ha; Alia Hdeib; David Goldenberg; Heather Jacene; Pavni Patel; Wayne Koch; Joseph Califano; Charles W Cummings; Paul W Flint; Richard Wahl; Ralph P Tufano
Journal:  Arch Otolaryngol Head Neck Surg       Date:  2006-01

3.  Pretherapeutic staging of hypopharyngeal carcinoma. Clinical findings, computed tomography, and magnetic resonance imaging compared with histopathologic evaluation.

Authors:  P Zbären; M Becker; H Läng
Journal:  Arch Otolaryngol Head Neck Surg       Date:  1997-09

4.  Screening for distant metastases in patients with head and neck cancer: is chest computed tomography sufficient?

Authors:  Jolijn Brouwer; Remco de Bree; Otto S Hoekstra; Richard P Golding; Johannes A Langendijk; Jonas A Castelijns; C René Leemans
Journal:  Laryngoscope       Date:  2005-10       Impact factor: 3.325

Review 5.  Review of segmental and marginal resection of the mandible in patients with oral cancer.

Authors:  M Politi; F Costa; M Robiony; A Rinaldo; A Ferlito
Journal:  Acta Otolaryngol       Date:  2000-08       Impact factor: 1.494

6.  Positron emission tomography with [18F]fluorodeoxyglucose improves staging and patient management in patients with head and neck squamous cell carcinoma: a multicenter prospective study.

Authors:  Max Lonneux; Marc Hamoir; Hervé Reychler; Philippe Maingon; Christian Duvillard; Gilles Calais; Boumédiène Bridji; Laurence Digue; Michel Toubeau; Vincent Grégoire
Journal:  J Clin Oncol       Date:  2010-02-01       Impact factor: 44.544

7.  PET changes management and improves prognostic stratification in patients with head and neck cancer: results of a multicenter prospective study.

Authors:  Andrew M Scott; Dishan H Gunawardana; Dylan Bartholomeusz; Jayne E Ramshaw; Peter Lin
Journal:  J Nucl Med       Date:  2008-09-15       Impact factor: 10.057

Review 8.  Perineural spread in head and neck malignancies: clinical significance and evaluation with 18F-FDG PET/CT.

Authors:  Fabio M Paes; Adam D Singer; Adam N Checkver; Ricardo A Palmquist; Gabriela De La Vega; Charif Sidani
Journal:  Radiographics       Date:  2013-10       Impact factor: 5.333

Review 9.  Perineural invasion in cancer: a review of the literature.

Authors:  Catherine Liebig; Gustavo Ayala; Jonathan A Wilks; David H Berger; Daniel Albo
Journal:  Cancer       Date:  2009-08-01       Impact factor: 6.860

10.  18F-Fluorodeoxyglucose-PET/CT to evaluate tumor, nodal disease, and gross tumor volume of oropharyngeal and oral cavity cancer: comparison with MR imaging and validation with surgical specimen.

Authors:  Oliver Seitz; Nicole Chambron-Pinho; Markus Middendorp; Rober Sader; Martin Mack; Thomas J Vogl; Sotirios Bisdas
Journal:  Neuroradiology       Date:  2009-10       Impact factor: 2.804

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