Guo-Zeng Xu1, Xiao-Dong Zhu, Ming-Yao Li. 1. Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Abstract
BACKGROUND: A meta-analysis was conducted to evaluate the accuracy of whole-body positron emission tomography (PET) and PET-CT in initial M staging of head and neck cancer. METHODS: After a systematic review of English language studies, sensitivity, specificity, and other measures of whole-body PET and PET-CT were pooled. Summary receiver operating characteristic (SROC) curves were also used to summarize overall test performance. RESULTS: Eight PET and 7 PET-CT studies were identified. The pooled sensitivity estimates for PET and PET-CT were 0.848 (95% confidence interval [CI], 0.776-0.905) and 0.875 (95% CI, 0.787-0.936). The pooled specificity estimates were 0.952 (95% CI, 0.933-0.967) and 0.950 (95% CI, 0.931-0.964). The Q* index estimates for PET-CT (0.9409) were not significantly higher than for PET (0.9154; p > .05). CONCLUSION: Whole-body PET and PET-CT have good diagnostic performance in initial M staging of head and neck cancer; although PET-CT tends to have higher accuracy than PET.
BACKGROUND: A meta-analysis was conducted to evaluate the accuracy of whole-body positron emission tomography (PET) and PET-CT in initial M staging of head and neck cancer. METHODS: After a systematic review of English language studies, sensitivity, specificity, and other measures of whole-body PET and PET-CT were pooled. Summary receiver operating characteristic (SROC) curves were also used to summarize overall test performance. RESULTS: Eight PET and 7 PET-CT studies were identified. The pooled sensitivity estimates for PET and PET-CT were 0.848 (95% confidence interval [CI], 0.776-0.905) and 0.875 (95% CI, 0.787-0.936). The pooled specificity estimates were 0.952 (95% CI, 0.933-0.967) and 0.950 (95% CI, 0.931-0.964). The Q* index estimates for PET-CT (0.9409) were not significantly higher than for PET (0.9154; p > .05). CONCLUSION: Whole-body PET and PET-CT have good diagnostic performance in initial M staging of head and neck cancer; although PET-CT tends to have higher accuracy than PET.
Authors: Val J Lowe; Fenghai Duan; Rathan M Subramaniam; JoRean D Sicks; Justin Romanoff; Twyla Bartel; Jian Q Michael Yu; Brian Nussenbaum; Jeremy Richmon; Charles D Arnold; David Cognetti; Brendan C Stack Journal: J Clin Oncol Date: 2019-02-15 Impact factor: 44.544
Authors: Jon Cacicedo; Arturo Navarro; Olga Del Hoyo; Alfonso Gomez-Iturriaga; Filippo Alongi; Jose A Medina; Olgun Elicin; Andrea Skanjeti; Francesco Giammarile; Pedro Bilbao; Francisco Casquero; Berardino de Bari; Alan Dal Pra Journal: Br J Radiol Date: 2016-08-02 Impact factor: 3.039
Authors: Rustain L Morgan; Megan M Eguchi; Adam C Mueller; Stacie L Daugherty; Arya Amini; Sana D Karam Journal: Cancer Date: 2019-05-01 Impact factor: 6.860