Ardeshir R Rastinehad1, Steven F Abboud2, Arvin K George2, Thomas P Frye2, Richard Ho2, Raju Chelluri2, Michele Fascelli2, Joanna Shih3, Robert Villani4, Eran Ben-Levi4, Oksana Yaskiv5, Baris Turkbey6, Peter L Choyke6, Maria J Merino7, Bradford J Wood8, Peter A Pinto9. 1. Department of Urology and Radiology, Icahn School of Medicine at Mount Sinai, New York, New York. 2. Urologic Oncology Branch, National Institutes of Health, Bethesda, Maryland. 3. Biometric Research Branch, National Institutes of Health, Bethesda, Maryland. 4. Department of Radiology, North Shore-Long Island Jewish Hofstra School of Medicine, New Hyde Park, New York. 5. Department of Pathology, North Shore-Long Island Jewish Hofstra School of Medicine, New Hyde Park, New York. 6. Molecular Imaging Program, National Institutes of Health, Bethesda, Maryland. 7. Laboratory of Pathology, National Institutes of Health, Bethesda, Maryland. 8. Center for Interventional Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. 9. Urologic Oncology Branch, National Institutes of Health, Bethesda, Maryland. Electronic address: pintop@mail.nih.gov.
Abstract
PURPOSE: As the adoption of magnetic resonance imaging/ultrasound fusion guided biopsy expands, the reproducibility of outcomes at expert centers becomes essential. We sought to validate the comprehensive NCI (National Cancer Institute) experience with multiparametric magnetic resonance imaging and fusion guided biopsy in an external, independent, matched cohort of patients. MATERIALS AND METHODS: We compared 620 patients enrolled in a prospective trial comparing systematic biopsy to fusion guided biopsy at NCI to 310 who underwent a similar procedure at Long Island Jewish Medical Center. The propensity score, defined as the probability of being treated outside NCI, was calculated using the estimated logistic regression model. Patients from the hospital were matched 1:1 for age, prostate specific antigen, magnetic resonance imaging suspicion score and prior negative biopsies. Clinically significant disease was defined as Gleason 3 + 4 or greater. RESULTS: Before matching we found differences between the cohorts in age, magnetic resonance imaging suspicion score (each p <0.001), the number of patients with prior negative biopsies (p = 0.01), and the overall cancer detection rate and the cancer detection rate by fusion guided biopsy (each p <0.001). No difference was found in the rates of upgrading by fusion guided biopsy (p = 0.28) or upgrading to clinically significant disease (p = 0.95). A statistically significant difference remained in the overall cancer detection rate and the rate by fusion guided biopsy after matching. On subgroup analysis we found a difference in the overall cancer detection rate and the rate by fusion guided biopsy (p <0.001 and 0.003) in patients with prior negative systematic biopsy but no difference in the 2 rates (p = 0.39 and 0.51, respectively) in biopsy naïve patients. CONCLUSIONS: Improved detection of clinically significant cancer by magnetic resonance imaging and fusion guided biopsy is reproducible by an experienced multidisciplinary team consisting of dedicated radiologists and urologists.
PURPOSE: As the adoption of magnetic resonance imaging/ultrasound fusion guided biopsy expands, the reproducibility of outcomes at expert centers becomes essential. We sought to validate the comprehensive NCI (National Cancer Institute) experience with multiparametric magnetic resonance imaging and fusion guided biopsy in an external, independent, matched cohort of patients. MATERIALS AND METHODS: We compared 620 patients enrolled in a prospective trial comparing systematic biopsy to fusion guided biopsy at NCI to 310 who underwent a similar procedure at Long Island Jewish Medical Center. The propensity score, defined as the probability of being treated outside NCI, was calculated using the estimated logistic regression model. Patients from the hospital were matched 1:1 for age, prostate specific antigen, magnetic resonance imaging suspicion score and prior negative biopsies. Clinically significant disease was defined as Gleason 3 + 4 or greater. RESULTS: Before matching we found differences between the cohorts in age, magnetic resonance imaging suspicion score (each p <0.001), the number of patients with prior negative biopsies (p = 0.01), and the overall cancer detection rate and the cancer detection rate by fusion guided biopsy (each p <0.001). No difference was found in the rates of upgrading by fusion guided biopsy (p = 0.28) or upgrading to clinically significant disease (p = 0.95). A statistically significant difference remained in the overall cancer detection rate and the rate by fusion guided biopsy after matching. On subgroup analysis we found a difference in the overall cancer detection rate and the rate by fusion guided biopsy (p <0.001 and 0.003) in patients with prior negative systematic biopsy but no difference in the 2 rates (p = 0.39 and 0.51, respectively) in biopsy naïve patients. CONCLUSIONS: Improved detection of clinically significant cancer by magnetic resonance imaging and fusion guided biopsy is reproducible by an experienced multidisciplinary team consisting of dedicated radiologists and urologists.
Authors: Annerleim Walton Diaz; Nabeel Ahmad Shakir; Arvin K George; Soroush Rais-Bahrami; Baris Turkbey; Jason T Rothwax; Lambros Stamatakis; Cheng William Hong; Mohummad Minhaj Siddiqui; Chinonyerem Okoro; Dima Raskolnikov; Daniel Su; Joanna Shih; Hui Han; Howard L Parnes; Maria J Merino; Richard M Simon; Bradford J Wood; Peter L Choyke; Peter A Pinto Journal: Urol Oncol Date: 2015-03-06 Impact factor: 3.498
Authors: Mitchell Kamrava; Amar U Kishan; Daniel J Margolis; Jiaoti Huang; Fred Dorey; Patricia Lieu; Patrick A Kupelian; Leonard S Marks Journal: Pract Radiat Oncol Date: 2015-06-06
Authors: Berrend G Muller; Joanna H Shih; Sandeep Sankineni; Jamie Marko; Soroush Rais-Bahrami; Arvin Koruthu George; Jean J M C H de la Rosette; Maria J Merino; Bradford J Wood; Peter Pinto; Peter L Choyke; Baris Turkbey Journal: Radiology Date: 2015-06-18 Impact factor: 11.105
Authors: Simon L Conti; Marc Dall'era; Vincent Fradet; Janet E Cowan; Jeffery Simko; Peter R Carroll Journal: J Urol Date: 2009-02-23 Impact factor: 7.450
Authors: Berrend G Muller; Aradhana Kaushal; Sandeep Sankineni; Elena Lita; Anthony N Hoang; Arvin K George; Soroush Rais-Bahrami; Jochen Kruecker; Pingkun Yan; Sheng Xu; Jean J de la Rosette; Maria J Merino; Bradford J Wood; Peter A Pinto; Peter L Choyke; Baris Turkbey Journal: Urol Oncol Date: 2015-08-08 Impact factor: 3.498
Authors: Soroush Rais-Bahrami; M Minhaj Siddiqui; Baris Turkbey; Lambros Stamatakis; Jennifer Logan; Anthony N Hoang; Annerleim Walton-Diaz; Srinivas Vourganti; Hong Truong; Jochen Kruecker; Maria J Merino; Bradford J Wood; Peter L Choyke; Peter A Pinto Journal: J Urol Date: 2013-05-29 Impact factor: 7.450
Authors: Michael S Cohen; Robert S Hanley; Teodora Kurteva; Robin Ruthazer; Mark L Silverman; Andrea Sorcini; Karim Hamawy; Robert A Roth; Ingolf Tuerk; John A Libertino Journal: Eur Urol Date: 2008-03-28 Impact factor: 20.096
Authors: M Kongnyuy; M M Siddiqui; A K George; A Muthigi; A Sidana; M Maruf; B Turkbey; P L Choyke; B J Wood; P A Pinto Journal: Prostate Cancer Prostatic Dis Date: 2017-04-25 Impact factor: 5.554
Authors: Matthew J Watson; Arvin K George; Mahir Maruf; Thomas P Frye; Akhil Muthigi; Michael Kongnyuy; Subin G Valayil; Peter A Pinto Journal: Future Oncol Date: 2016-07-12 Impact factor: 3.404
Authors: Akhil Muthigi; Arvin K George; Abhinav Sidana; Michael Kongnyuy; Richard Simon; Vanessa Moreno; Maria J Merino; Peter L Choyke; Baris Turkbey; Bradford J Wood; Peter A Pinto Journal: J Urol Date: 2016-08-28 Impact factor: 7.450
Authors: Akhil Muthigi; Abhinav Sidana; Arvin K George; Michael Kongnyuy; Nabeel Shakir; Meet Kadakia; Mahir Maruf; Thomas P Frye; Francesca Mertan; Daniel Su; Maria J Merino; Peter L Choyke; Baris Turkbey; Bradford J Wood; Peter A Pinto Journal: Int Urol Nephrol Date: 2016-06-15 Impact factor: 2.370
Authors: Ariel A Schulman; Christina Sze; Efrat Tsivian; Rajan T Gupta; Judd W Moul; Thomas J Polascik Journal: Curr Urol Rep Date: 2017-07 Impact factor: 3.092
Authors: Arvin K George; Baris Turkbey; Subin G Valayil; Akhil Muthigi; Francesca Mertan; Michael Kongnyuy; Peter A Pinto Journal: Abdom Radiol (NY) Date: 2016-05
Authors: Bruce J Trock; Helen Fedor; Bora Gurel; Robert B Jenkins; B S Knudsen; Samson W Fine; Jonathan W Said; H Ballentine Carter; Tamara L Lotan; Angelo M De Marzo Journal: Mod Pathol Date: 2016-04-15 Impact factor: 7.842