| Literature DB >> 26812172 |
Chung Sub Kim1, Lalita Subedi2,3, Sun Yeou Kim2,3, Sang Un Choi4, Ki Hyun Kim1, Kang Ro Lee1.
Abstract
Eleven new abietane-type diterpenes, holophyllins D-N (1-11), and 17 known analogues (12-28), were isolated from a MeOH extract of the trunk of Abies holophylla. The chemical structures of 1-11 were determined through spectroscopic data analysis, including NMR ((1)H and (13)C NMR, DEPT, (1)H-(1)H COSY, HMQC, HMBC, and NOESY) and HRFABMS methods. All isolated compounds (1-28) were evaluated for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116), for their potential neuroprotective effects through induction of nerve growth factor in C6 glioma cells, and for their effects on nitric oxide levels in lipopolysaccharide-stimulated murine microglia BV2 cells.Entities:
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Year: 2016 PMID： 26812172 DOI： 10.1021/acs.jnatprod.5b01053
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050