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Literature DB >> 33414855

Chemical constituents of Chaenomeles sinensis twigs and their biological activity.

Joon Min Cha¹, Dong Hyun Kim¹, Lalita Subedi², Zahra Khan², Sang Un Choi³, Sun Yeou Kim^2,4, Chung Sub Kim¹.

Abstract

A new megastigmane-type norsesquiterpenoid glycoside, chaemeloside (1), was isolated from the twigs of Chaenomeles sinensis together with 11 known phytochemicals through chromatographic methods. The chemical structure of the new isolate 1 was determined by conventional 1D and 2D NMR data analysis, ECD experiment, hydrolysis followed by a modified Mosher's method, and LC-MS analysis. The characterized compounds' biological effects including cytotoxicity against cancer cell lines, antineuroinflammatory activity, and potential neurotrophic effect were evaluated.

Entities: CellLine Chemical Disease Gene Species

Keywords: Chaenomeles sinensis; antineuroinflammation; cytotoxicity; megastigmane; neurotrophic effect

Year: 2020 PMID： 33414855 PMCID： PMC7753107 DOI： 10.3762/bjoc.16.257

Source DB: PubMed Journal: Beilstein J Org Chem ISSN： 1860-5397 Impact factor: 2.883

29 in total

1. Bioactivity-guided isolation of cytotoxic triterpenoids from the trunk of Berberis koreana.

Authors: Ki Hyun Kim; Sang Un Choi; Kang Ro Lee
Journal: Bioorg Med Chem Lett Date: 2010-02-04 Impact factor: 2.823

2. Five new oxylipins from Chaenomeles sinensis.

Authors: Chung Sub Kim; Oh Wook Kwon; Sun Yeou Kim; Sang Un Choi; Ki Hyun Kim; Kang Ro Lee
Journal: Lipids Date: 2014-09-26 Impact factor: 1.880

3. A new in vitro tissue factor inhibitory triterpene from the fruits of Chaenomeles sinensis.

Authors: Ming Hong Lee; Yong Nam Han
Journal: Planta Med Date: 2003-04 Impact factor: 3.352

4. Securinega Alkaloids from the Twigs of Securinega suffruticosa and Their Biological Activities.

Authors: Kyoung Jin Park; Chung Sub Kim; Zahra Khan; Joonseok Oh; Sun Yeou Kim; Sang Un Choi; Kang Ro Lee
Journal: J Nat Prod Date: 2019-05-13 Impact factor: 4.050

5. A new acylglycosyl sterol from Quisqualis Fructus.

Authors: Hak Cheol Kwon; Young Duk Min; Kyung Ran Kim; Eun Jung Bang; Chong Soon Lee; Kang Ro Lee
Journal: Arch Pharm Res Date: 2003-04 Impact factor: 4.946

6. Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1beta by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells.

Authors: Y Choi; M K Lee; S Y Lim; S H Sung; Y C Kim
Journal: Br J Pharmacol Date: 2009-03 Impact factor: 8.739

Chemical constituents of Chaenomeles sinensis twigs and their biological activity.

1. Bioactivity-guided isolation of cytotoxic triterpenoids from the trunk of Berberis koreana.

2. Five new oxylipins from Chaenomeles sinensis.

3. A new in vitro tissue factor inhibitory triterpene from the fruits of Chaenomeles sinensis.

4. Securinega Alkaloids from the Twigs of Securinega suffruticosa and Their Biological Activities.

5. A new acylglycosyl sterol from Quisqualis Fructus.

6. Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1beta by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells.

7. Antipruritic effects of the fruits of Chaenomeles sinensis.

8. Bioassay-guided Isolation of Antiproliferative Triterpenoids from Euonymus alatus Twigs.

9. Terpenic and phenolic glycosides from leaves of Breynia officinalis HEMSL.

10. Facile discrimination of aldose enantiomers by reversed-phase HPLC.

1. Terpenoids from Glechoma hederacea var. longituba and their biological activities.