Literature DB >> 2681119

Effects of ascorbic acid on the antifungal action of amphotericin B.

J Brajtburg1, S Elberg, G S Kobayashi, G Medoff.   

Abstract

Ascorbic acid enhanced the lethal but not the permeabilizing effects of amphotericin B on Candida albicans and Cryptococcus neoformans cells. Two other ene-diol acids, D-erythorbate and dihydroxyfumarate, also enhanced the lethal action of amphotericin B on Can. albicans. Maleic acid and gulanolactone, compounds structurally related to ascorbic acid but not containing the ene-diol group, had no such effect. It is assumed that ascorbic acid and the two other ene-diol acids acting as pro-oxidants augmented the oxidation-dependent killing of fungal cells induced by amphotericin B.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2681119     DOI： 10.1093/jac/24.3.333

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  6 in total

1.  Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains.

Authors:  Michael Blatzer; Gerhard Blum; Emina Jukic; Wilfried Posch; Peter Gruber; Markus Nagl; Ulrike Binder; Elisabeth Maurer; Bettina Sarg; Herbert Lindner; Cornelia Lass-Flörl; Doris Wilflingseder
Journal:  Antimicrob Agents Chemother       Date:  2015-04-13       Impact factor: 5.191

2.  The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug.

Authors:  Ana Cecilia Mesa-Arango; Nuria Trevijano-Contador; Elvira Román; Ruth Sánchez-Fresneda; Celia Casas; Enrique Herrero; Juan Carlos Argüelles; Jesús Pla; Manuel Cuenca-Estrella; Oscar Zaragoza
Journal:  Antimicrob Agents Chemother       Date:  2014-08-25       Impact factor: 5.191

Review 3.  Amphotericin B: current understanding of mechanisms of action.

Authors:  J Brajtburg; W G Powderly; G S Kobayashi; G Medoff
Journal:  Antimicrob Agents Chemother       Date:  1990-02       Impact factor: 5.191

4.  Sodium ascorbate kills Candida albicans in vitro via iron-catalyzed Fenton reaction: importance of oxygenation and metabolism.

Authors:  Pinar Avci; Fernanda Freire; Andras Banvolgyi; Eleftherios Mylonakis; Norbert M Wikonkal; Michael R Hamblin
Journal:  Future Microbiol       Date:  2016-11-18       Impact factor: 3.165

5.  Effects of ascorbic acid on Chlamydia trachomatis infection and on erythromycin treatment in primary cultures of human amniotic cells.

Authors:  S K Wang; D L Patton; C C Kuo
Journal:  J Clin Microbiol       Date:  1992-10       Impact factor: 5.948

6.  Influence of ascorbic acid and α-tocopherol on the autoxidation and in vitro antifungal activity of amphotericin B.

Authors:  Mohammed Habib Belhachemi; Zahia Boucherit-Otmani; Kebir Boucherit; Sara Belmir
Journal:  Curr Med Mycol       Date:  2021-03
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.