Julián Benito-León1, Elan D Louis2, Verónica Puertas-Martín3, Juan Pablo Romero4, Michele Matarazzo3, José Antonio Molina-Arjona3, Cristina Domínguez-González3, Álvaro Sánchez-Ferro5. 1. Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, (CIBERNED), Madrid, Spain; Department of Medicine, Complutense University, Madrid, Spain. Electronic address: jbenitol67@gmail.com. 2. Department of Neurology, Yale School of Medicine, New Haven, CT, USA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA; Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine and Yale School of Public Health, New Haven, CT, USA. 3. Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain. 4. Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Faculty of Biosanitary Sciences, Francisco de Vitoria University, Pozuelo de Alarcón, Madrid, Spain. 5. Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain; Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA; HM CINAC, HM Hospitales, Móstoles, Madrid, Spain.
Abstract
INTRODUCTION: Evidence suggests that the cerebellum could play a role in the pathophysiology of orthostatic tremor. The link between orthostatic tremor and the cerebellum is of interest, especially in light of the role the cerebellum plays in cognition, and it raises the possibility that orthostatic tremor patients could have cognitive deficits consistent with cerebellar dysfunction. Our aim was to examine whether orthostatic tremor patients had cognitive deficits and distinct personality profiles when compared with matched controls. METHODS: Sixteen consecutive orthostatic tremor patients (65.7 ± 13.3 years) and 32 healthy matched controls underwent a neuropsychological battery and the Personality Assessment Inventory. In linear regression models, the dependent variable was each one of the neuropsychological test scores or the Personality Assessment Inventory subscales and the independent variable was orthostatic tremor vs. RESULTS: Adjusted for age in years, sex, years of education, comorbidity index, current smoker, and depressive symptoms, diagnosis (orthostatic tremor vs. healthy control) was associated with poor performance on tests of executive function, visuospatial ability, verbal memory, visual memory, and language tests, and on a number of the Personality Assessment Inventory subscales (somatic concerns, anxiety related disorders, depression, and antisocial features). Older-onset OT (>60 years) patients had poorer scores on cognitive and personality testing compared with their younger-onset OT counterparts. CONCLUSION: Orthostatic tremor patients have deficits in specific aspects of neuropsychological functioning, particularly those thought to rely on the integrity of the prefrontal cortex, which suggests involvement of frontocerebellar circuits. Cognitive impairment and personality disturbances could be disease-associated nonmotor manifestations of orthostatic tremor.
INTRODUCTION: Evidence suggests that the cerebellum could play a role in the pathophysiology of orthostatic tremor. The link between orthostatic tremor and the cerebellum is of interest, especially in light of the role the cerebellum plays in cognition, and it raises the possibility that orthostatic tremorpatients could have cognitive deficits consistent with cerebellar dysfunction. Our aim was to examine whether orthostatic tremorpatients had cognitive deficits and distinct personality profiles when compared with matched controls. METHODS: Sixteen consecutive orthostatic tremorpatients (65.7 ± 13.3 years) and 32 healthy matched controls underwent a neuropsychological battery and the Personality Assessment Inventory. In linear regression models, the dependent variable was each one of the neuropsychological test scores or the Personality Assessment Inventory subscales and the independent variable was orthostatic tremor vs. RESULTS: Adjusted for age in years, sex, years of education, comorbidity index, current smoker, and depressive symptoms, diagnosis (orthostatic tremor vs. healthy control) was associated with poor performance on tests of executive function, visuospatial ability, verbal memory, visual memory, and language tests, and on a number of the Personality Assessment Inventory subscales (somatic concerns, anxiety related disorders, depression, and antisocial features). Older-onset OT (>60 years) patients had poorer scores on cognitive and personality testing compared with their younger-onset OT counterparts. CONCLUSION:Orthostatic tremorpatients have deficits in specific aspects of neuropsychological functioning, particularly those thought to rely on the integrity of the prefrontal cortex, which suggests involvement of frontocerebellar circuits. Cognitive impairment and personality disturbances could be disease-associated nonmotor manifestations of orthostatic tremor.
Authors: Willibald Gerschlager; Alexander Münchau; Regina Katzenschlager; Peter Brown; John C Rothwell; Niall Quinn; Andrew J Lees; Kailash P Bhatia Journal: Mov Disord Date: 2004-07 Impact factor: 10.338
Authors: Verónica Puertas-Martín; Alberto Villarejo-Galende; Sara Fernández-Guinea; Juan Pablo Romero; Elan D Louis; Julián Benito-León Journal: Tremor Other Hyperkinet Mov (N Y) Date: 2016-12-15
Authors: Julián Benito-León; Elan D Louis; Virginia Mato-Abad; Ulrike Dydak; Juan Álvarez-Linera; Juan Antonio Hernández-Tamames; José Antonio Molina-Arjona; Norberto Malpica; Michele Matarazzo; Juan Pablo Romero; Álvaro Sánchez-Ferro Journal: Medicine (Baltimore) Date: 2016-09 Impact factor: 1.889
Authors: J Ignacio Serrano; Juan P Romero; Ma Dolores Del Castillo; Eduardo Rocon; Elan D Louis; Julián Benito-León Journal: Sci Rep Date: 2017-05-19 Impact factor: 4.379
Authors: D E Bhatti; R J Thompson; K Malgireddy; N M Syed; B Bayer; D Bessette; M H Fleisher; D L Murman; D Torres-Russotto Journal: Clin Park Relat Disord Date: 2019-07-17