M U Manto1, F Setta, B Legros, J Jacquy, E Godaux. 1. Department of Neurology, Hôpital Erasme, Belgian National Research Foundation, Brussels, Belgium. Neurolog@ulb.ac.be
Abstract
OBJECTIVES: To investigate the resetting effects of transcranial magnetic stimulation over motor cortex on orthostatic tremor, characterized by high-frequency electromyographic discharges in weight-bearing muscles, particularly orthostatic tremor (OT) associated with cerebellar cortical atrophy; and to compare our results with those obtained in primary OT, for which transcranial magnetic stimulation does not reset tremor. DESIGN: Study of 3 patients who clinically exhibited a sporadic pancerebellar syndrome associated with isolated cerebellar atrophy and features of OT. SETTING: Research hospital. MAIN OUTCOME MEASURES: Electromyograms and transcranial magnetic stimulation studies with a resetting index calculated on the basis of the timing of measured bursts and predicted bursts for a magnetic stimulus given at increasing delays. RESULTS: Surface electromyographic recordings in weight-bearing muscles showed tremor with a frequency of 14, 15, and 14 Hz in the 3 patients. Transcranial magnetic stimulus was able to reset OT. Resetting index was 0.72. CONCLUSIONS: Transcranial magnetic stimulus resets OT associated with cerebellar cortical atrophy, emphasizing the role of motor cortex in the genesis of OT associated with a cerebellar dysfunction. Our results argue in favor of a distinct pathophysiological mechanism of primary OT and OT associated with cerebellar cortical atrophy.
OBJECTIVES: To investigate the resetting effects of transcranial magnetic stimulation over motor cortex on orthostatic tremor, characterized by high-frequency electromyographic discharges in weight-bearing muscles, particularly orthostatic tremor (OT) associated with cerebellar cortical atrophy; and to compare our results with those obtained in primary OT, for which transcranial magnetic stimulation does not reset tremor. DESIGN: Study of 3 patients who clinically exhibited a sporadic pancerebellar syndrome associated with isolated cerebellar atrophy and features of OT. SETTING: Research hospital. MAIN OUTCOME MEASURES: Electromyograms and transcranial magnetic stimulation studies with a resetting index calculated on the basis of the timing of measured bursts and predicted bursts for a magnetic stimulus given at increasing delays. RESULTS: Surface electromyographic recordings in weight-bearing muscles showed tremor with a frequency of 14, 15, and 14 Hz in the 3 patients. Transcranial magnetic stimulus was able to reset OT. Resetting index was 0.72. CONCLUSIONS: Transcranial magnetic stimulus resets OT associated with cerebellar cortical atrophy, emphasizing the role of motor cortex in the genesis of OT associated with a cerebellar dysfunction. Our results argue in favor of a distinct pathophysiological mechanism of primary OT and OT associated with cerebellar cortical atrophy.
Authors: Julián Benito-León; Elan D Louis; Verónica Puertas-Martín; Juan Pablo Romero; Michele Matarazzo; José Antonio Molina-Arjona; Cristina Domínguez-González; Álvaro Sánchez-Ferro Journal: J Neurol Sci Date: 2015-12-21 Impact factor: 3.181
Authors: Julián Benito-León; Elan D Louis; Virginia Mato-Abad; Ulrike Dydak; Juan Álvarez-Linera; Juan Antonio Hernández-Tamames; José Antonio Molina-Arjona; Norberto Malpica; Michele Matarazzo; Juan Pablo Romero; Álvaro Sánchez-Ferro Journal: Medicine (Baltimore) Date: 2016-09 Impact factor: 1.889
Authors: Julián Benito-León; Juan P Romero; Elan D Louis; Alvaro Sánchez-Ferro; Michele Matarazzo; José A Molina-Arjona; Virginia Mato-Abad Journal: Ann Clin Transl Neurol Date: 2019-10-06 Impact factor: 4.511