Tsuyoshi Ueno1, Motohiro Yamashita2, Shigeki Sawada2, Ryujiro Sugimoto2, Noriko Nishijima3, Yoshifumi Sugawara3, Iku Ninomiya4. 1. Department of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, 160 Minami-Umemoto, Matsuyama, 791-0280, Japan. ueno0923@yahoo.co.jp. 2. Department of Thoracic Surgery, National Hospital Organization Shikoku Cancer Center, 160 Minami-Umemoto, Matsuyama, 791-0280, Japan. 3. Department of Radiology, National Hospital Organization Shikoku Cancer Center, 160 Minami-Umemoto, Matsuyama, 791-0280, Japan. 4. Department of Urology, National Hospital Organization Shikoku Cancer Center, 160 Minami-Umemoto, Matsuyama, 791-0280, Japan.
Abstract
INTRODUCTION: Usefulness of complete metastasectomy against pulmonary metastases from renal cell carcinoma (RCC) is well known. We examined the efficacy of surgical resection of pulmonary metastases from RCC performed in Shikoku Cancer Center. METHOD: Between January 2004 and December 2014, 11 patients with pulmonary metastases from RCC underwent thoracic resection in our institution. We examined disease-free interval (DFI) and overall survival of these patients after pulmonary metastasectomy. RESULTS: Patients included 9 men and 2 women with a mean age of 63.2 years. The median number of metastases was 1 (range 1-6). Overall, 5 patients had a single metastasis (45.5%), 8 patients had unilateral metastases (72.7%), and 3 patients received immunotherapy or chemotherapy in the interval between radical nephrectomy and pulmonary metastasectomy. We performed complete pulmonary metastasectomy in these patients. The median observation period was 43 months (range 5-82), median DFI was 5 months (range 2-17), and 3-year overall survival rate was 86%. In the 3 patients who had primary or metastatic tumors with sarcomatoid (SA) component, their median DFI tended to be shorter than that of 8 patients without it (2 vs. 8 months, p = 0.07). CONCLUSION: The pulmonary metastasectomy for RCC is a treatment option, while the indication for RCC with SA component should be carefully considered.
INTRODUCTION: Usefulness of complete metastasectomy against pulmonary metastases from renal cell carcinoma (RCC) is well known. We examined the efficacy of surgical resection of pulmonary metastases from RCC performed in Shikoku Cancer Center. METHOD: Between January 2004 and December 2014, 11 patients with pulmonary metastases from RCC underwent thoracic resection in our institution. We examined disease-free interval (DFI) and overall survival of these patients after pulmonary metastasectomy. RESULTS:Patients included 9 men and 2 women with a mean age of 63.2 years. The median number of metastases was 1 (range 1-6). Overall, 5 patients had a single metastasis (45.5%), 8 patients had unilateral metastases (72.7%), and 3 patients received immunotherapy or chemotherapy in the interval between radical nephrectomy and pulmonary metastasectomy. We performed complete pulmonary metastasectomy in these patients. The median observation period was 43 months (range 5-82), median DFI was 5 months (range 2-17), and 3-year overall survival rate was 86%. In the 3 patients who had primary or metastatic tumors with sarcomatoid (SA) component, their median DFI tended to be shorter than that of 8 patients without it (2 vs. 8 months, p = 0.07). CONCLUSION: The pulmonary metastasectomy for RCC is a treatment option, while the indication for RCC with SA component should be carefully considered.
Authors: M de Peralta-Venturina; H Moch; M Amin; P Tamboli; S Hailemariam; M Mihatsch; J Javidan; H Stricker; J Y Ro; M B Amin Journal: Am J Surg Pathol Date: 2001-03 Impact factor: 6.394
Authors: M Dror Michaelson; Rana R McKay; Lillian Werner; Michael B Atkins; Eliezer M Van Allen; Kara M Olivier; Jiaxi Song; Sabina Signoretti; David F McDermott; Toni K Choueiri Journal: Cancer Date: 2015-06-08 Impact factor: 6.860