Literature DB >> 26809466

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma.

Zhi Xu1, Chunxiang Cao2, Haiyan Xia2, Shujing Shi2, Lingzhi Hong2, Xiaowei Wei2, Dongying Gu2, Jianmin Bian3, Zijun Liu3, Wenbin Huang4, Yixin Zhang5, Song He6, Nikki Pui-Yue Lee7, Jinfei Chen8.   

Abstract

Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed in the majority of HCC cases (approximately 59%) and significantly associated with high serum α-fetoprotein (AFP) level (P = 0.044). Kaplan- Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCCspecific overall survival (HR, 2.799; 95% CI, 1.346-5.818, P = 0.006). Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.

Entities:  

Keywords:  PPM1D; hepatocellular carcinoma; prognosis; target therapy

Mesh：

Substances：

Year:  2016        PMID： 26809466     DOI： 10.1007/s11684-016-0433-3

Source DB:  PubMed          Journal:  Front Med        ISSN： 2095-0217            Impact factor:   4.592


  29 in total

1.  Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.

Authors:  Jing Li; Ying Yang; Yue Peng; Richard J Austin; Winfried G van Eyndhoven; Ken C Q Nguyen; Tim Gabriele; Mila E McCurrach; Jeffrey R Marks; Timothy Hoey; Scott W Lowe; Scott Powers
Journal:  Nat Genet       Date:  2002-05-20       Impact factor: 38.330

Review 2.  p53, the cellular gatekeeper for growth and division.

Authors:  A J Levine
Journal:  Cell       Date:  1997-02-07       Impact factor: 41.582

3.  Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells.

Authors:  Tao Zhang; Junping Zhang; Xiaona You; Qian Liu; Yumei Du; Yuen Gao; Changliang Shan; Guangyao Kong; Youliang Wang; Xiao Yang; Lihong Ye; Xiaodong Zhang
Journal:  Hepatology       Date:  2012-11-13       Impact factor: 17.425

4.  PPM1D is a potential target for 17q gain in neuroblastoma.

Authors:  Fumiko Saito-Ohara; Issei Imoto; Jun Inoue; Hajime Hosoi; Akira Nakagawara; Tohru Sugimoto; Johji Inazawa
Journal:  Cancer Res       Date:  2003-04-15       Impact factor: 12.701

Review 5.  Hepatocellular carcinoma.

Authors:  Alejandro Forner; Josep M Llovet; Jordi Bruix
Journal:  Lancet       Date:  2012-02-20       Impact factor: 79.321

6.  Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets.

Authors:  Akira Hirasawa; Fumiko Saito-Ohara; Jun Inoue; Daisuke Aoki; Nobuyuki Susumu; Tetsuji Yokoyama; Shiro Nozawa; Johji Inazawa; Issei Imoto
Journal:  Clin Cancer Res       Date:  2003-06       Impact factor: 12.531

Review 7.  Regulation of the Wip1 phosphatase and its effects on the stress response.

Authors:  Julie Lowe; Hyukjin Cha; Mi-Ok Lee; Sharlyn J Mazur; Ettore Appella; Albert J Fornace
Journal:  Front Biosci (Landmark Ed)       Date:  2012-01-01

8.  PPM1D silencing by RNA interference inhibits the proliferation of lung cancer cells.

Authors:  Chen Zhang; Yuanzhuo Chen; Mingsong Wang; Xianzhen Chen; Yongxin Li; E Song; Xiaoqing Liu; Sekwon Kim; Hu Peng
Journal:  World J Surg Oncol       Date:  2014-08-13       Impact factor: 2.754

9.  Protein phosphatase magnesium-dependent 1δ (PPM1D) mRNA expression is a prognosis marker for hepatocellular carcinoma.

Authors:  Guang-Bing Li; Xue-Li Zhang; Li Yuan; Qi-Qi Jiao; De-Jie Liu; Jun Liu
Journal:  PLoS One       Date:  2013-03-28       Impact factor: 3.240

10.  PPM1D is a prognostic marker and therapeutic target in colorectal cancer.

Authors:  Tian-Shu Peng; Yong-Heng He; Tian Nie; Xiang-Dang Hu; Hai-Yan Lu; Jian Yi; Yun-Fei Shuai; Min Luo
Journal:  Exp Ther Med       Date:  2014-06-06       Impact factor: 2.447
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  4 in total

1.  Wip1 is associated with tumorigenity and metastasis through MMP-2 in human intrahepatic cholangiocarcinoma.

Authors:  Sulai Liu; Bo Jiang; Hao Li; Zili He; Pin Lv; Chuang Peng; Yonggang Wang; Wei Cheng; Zhengquan Xu; Wei Chen; Zhengkai Liu; Bao Zhang; Shengqian Shen; Shuanglin Xiang
Journal:  Oncotarget       Date:  2017-05-23

2.  PPM1D is a potential prognostic biomarker and correlates with immune cell infiltration in hepatocellular carcinoma.

Authors:  Zhangtao Yu; Yinghui Song; Mengting Cai; Bo Jiang; Zhihua Zhang; Le Wang; Yu Jiang; Lianhong Zou; Xiehong Liu; Nanhui Yu; Xianhai Mao; Chuang Peng; Sulai Liu
Journal:  Aging (Albany NY)       Date:  2021-09-01       Impact factor: 5.955

3.  Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma.

Authors:  Björn Stolte; Amanda Balboni Iniguez; Neekesh V Dharia; Amanda L Robichaud; Amy Saur Conway; Ann M Morgan; Gabriela Alexe; Nathan J Schauer; Xiaoxi Liu; Gregory H Bird; Aviad Tsherniak; Francisca Vazquez; Sara J Buhrlage; Loren D Walensky; Kimberly Stegmaier
Journal:  J Exp Med       Date:  2018-07-25       Impact factor: 14.307

4.  Potentiality of Protein phosphatase Mg2+ /Mn2+ dependent 1D as a biomarker for predicting prognosis in acute myeloid leukemia patients.

Authors:  Meijia Yu; Jie Hu; Di He; Qi Chen; Suna Liu; Xiaoling Zhu; Bin Li
Journal:  J Clin Lab Anal       Date:  2020-01-03       Impact factor: 2.352
  4 in total

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