Literature DB >> 12021784

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.

Jing Li1, Ying Yang, Yue Peng, Richard J Austin, Winfried G van Eyndhoven, Ken C Q Nguyen, Tim Gabriele, Mila E McCurrach, Jeffrey R Marks, Timothy Hoey, Scott W Lowe, Scott Powers.   

Abstract

We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.

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Year:  2002        PMID： 12021784     DOI： 10.1038/ng888

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  109 in total

1.  The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.

Authors:  Thuy-Ai Nguyen; Scott D Slattery; Sung-Hwan Moon; Yolanda F Darlington; Xiongbin Lu; Lawrence A Donehower
Journal:  DNA Repair (Amst)       Date:  2010-05-06

2.  Transcriptional response of lymphoblastoid cells to ionizing radiation.

Authors:  Kuang-Yu Jen; Vivian G Cheung
Journal:  Genome Res       Date:  2003-08-12       Impact factor: 9.043

Review 3.  Crosstalk between the DNA damage response pathway and microRNAs.

Authors:  Cecil Han; Guohui Wan; Robert R Langley; Xinna Zhang; Xiongbin Lu
Journal:  Cell Mol Life Sci       Date:  2012-03-20       Impact factor: 9.261

Review 4.  Posttranslational modification of p53: cooperative integrators of function.

Authors:  David W Meek; Carl W Anderson
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-10-28       Impact factor: 10.005

5.  Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.

Authors:  Hyukjin Cha; Julie M Lowe; Henghong Li; Ji-Seon Lee; Galina I Belova; Dmitry V Bulavin; Albert J Fornace
Journal:  Cancer Res       Date:  2010-05-11       Impact factor: 12.701

6.  A small molecular scaffold for selective inhibition of Wip1 phosphatase.

Authors:  Jeong Bang; Hiroshi Yamaguchi; Stewart R Durell; Ettore Appella; Daniel H Appella
Journal:  ChemMedChem       Date:  2008-02       Impact factor: 3.466

7.  A perspective on DNA microarrays in pathology research and practice.

Authors:  Jonathan R Pollack
Journal:  Am J Pathol       Date:  2007-06-28       Impact factor: 4.307

8.  c-Myc potentiates the mitochondrial pathway of apoptosis by acting upstream of apoptosis signal-regulating kinase 1 (Ask1) in the p38 signalling cascade.

Authors:  Katia M Desbiens; Réna G Deschesnes; Mireille M Labrie; Yan Desfossés; Herman Lambert; Jacques Landry; Kerstin Bellmann
Journal:  Biochem J       Date:  2003-06-01       Impact factor: 3.857

9.  Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.

Authors:  Libor Macurek; Jan Benada; Erik Müllers; Vincentius A Halim; Kateřina Krejčíková; Kamila Burdová; Sona Pecháčková; Zdeněk Hodný; Arne Lindqvist; René H Medema; Jiri Bartek
Journal:  Cell Cycle       Date:  2012-01-15       Impact factor: 4.534

10.  WIP1 regulates the proliferation and invasion of nasopharyngeal carcinoma in vitro.

Authors:  Yongquan Zhang; Hong Sun; Guangxiang He; An Liu; Fengjun Wang; Lu Wang
Journal:  Tumour Biol       Date:  2014-05-07
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